D5W Placebo

OTHER3 trials

Conditions

Chemotherapy-induced NeutropeniaContrast Induced NephropathyCritically Ill

Phase 2

N-Acetylcysteine in Critically Ill Patients Undergoing Contrast Enhanced Computed Tomography

CompletedNCT00830193

Unity Health TorontoContrast Induced Nephropathy, Critically Ill

Start: 2002-08-31End: 2005-05-31Updated: 2009-01-27

Phase 3

Plinabulin vs. Pegfilgrastim in Patients With Solid Tumors Receiving Docetaxel Myelosuppressive Chemotherapy Phase 3

CompletedNCT03102606

BeyondSpring Pharmaceuticals Inc.Chemotherapy-induced Neutropenia

Start: 2018-05-29End: 2021-02-08Updated: 2024-08-29

Plinabulin vs. Pegfilgrastim in Prevention of TAC Induced Neutropenia

NCT03294577

BeyondSpring Pharmaceuticals Inc.Chemotherapy-induced Neutropenia

Start: 2019-10-23End: 2025-09-25Updated: 2021-01-15

Journal of Clinical Oncology2023-06-01

Abstract P1-12-10: Superior Effectiveness of Plinabulin (Plin) versus No-Treatment for Docetaxel (Doc)-Induced Neutropenia (N) and other Hematologic Complication in Breast Cancer (BC) Patients

Cancer Research2023-03-01

A Bioinformatic Approach to the Clinical Evaluation of Linear Commitment Versus Cloud (Continuum of Low Primed UnDifferentiated) Models for Hematopoiesis Using Plinabulin Clinical Trial Data

Blood2022-11-15

Real-world effectiveness of prophylactic granulocyte colony-stimulating factor (G-CSF) early (week 1) and late (weeks 2-3) in the cycle for the prevention of febrile neutropenia (FN) among patients (pts) with breast cancer (BC) after high FN–risk chemotherapy (chemo).

Journal of Clinical Oncology2022-06-011 citations

Efficacy of Plinabulin vs Pegfilgrastim for Prevention of Docetaxel-Induced Neutropenia in Patients With Solid Tumors

JAMA Network Open2022-01-2724 citations

Plinabulin Rapidly (within 24 Hours) Reverses Myelosuppression Induced By Chemotherapy

Blood2021-11-051 citations

Head-to-head comparison of single agent (SA) plinabulin (Plin) versus pegfilgrastim (Peg) for the prevention of chemotherapy-induced neutropenia (CIN) in the phase 3 trial PROTECTIVE-1.

Journal of Clinical Oncology2021-05-202 citations

Abstract PS13-34: Differential efficacy of pegfilgrastim (Peg) in patients (pts) with breast cancer (BC) versus other cancer types for the prevention of docetaxel (Doc) chemotherapy-induced neutropenia (CIN)

Cancer Research2021-02-15

Efficacy of Plinabulin vs Pegfilgrastim for Prevention of Chemotherapy-Induced Neutropenia in Adults With Non–Small Cell Lung Cancer

JAMA Oncology2020-09-2431 citations

Head-to-head comparison of the non-G-CSF small molecule single agent (SA) plinabulin with SA pegfilgrastim for the prevention of docetaxel chemotherapy (chemo)-induced neutropenia (CIN) in the protective-1 trial.

Journal of Clinical Oncology2020-05-20

Effect of plinabulin, a novel late-clinical stage immunotherapeutic agent on the adaptive and innate immune system.

Journal of Clinical Oncology2020-02-041 citations

A Randomized Phase 3 Clinical Trial of the Combination of Plinabulin (plin) + Pegfilgrastim (peg) Versus (vs) Peg Alone for Tac (docetaxel, doxorubicin, cyclophosphamide) Induced Neutropenia (cin)

Blood2019-11-131 citations

Clinical Evidence of Granulocyte-Monocyte Progenitor (GMP) Stem Cell Involvement in Plinabulin's Mechanism of Action (MoA) for the Prevention of Docetaxel (Doc) Chemotherapy (Chemo)-Induced Neutropenia (CIN)

Blood2019-11-131 citations

Clinical Evidence Against the Continuum of Low-Primed Uncommitted Hematopoietic and Progenitor Cells (CLOUD-HSPC) Concept for Hematopoiesis

Blood2019-11-13

Comparison of pegfilgrastim (Peg), plinabulin (Plin), and the combination for chemotherapy (Chemo) induced neutropenia (CIN) prevention: Rationale for the combination.

Journal of Clinical Oncology2019-05-20

Plinabulin (Plin) combined with half-dose pegfilgrastim (Peg) compared with full-dose peg alone for chemotherapy- induced-neutropenia (CIN): Neutrophil, bone pain, and immunosuppressive effects.

Journal of Clinical Oncology2019-05-20

A phase II trial with the combination of plinabulin (plin) pegfilgrastim (peg): Evaluation of the reversal of peg’s immune-suppressive potential by the addition of plin to peg.

Journal of Clinical Oncology2019-03-102 citations

Plinabulin, a Novel Small Molecule in Development for Chemotherapy-Induced-Neutropenia (CIN) Prevention, Mobilizes CD34+ Cells through a Mechanism of Action (MoA) Different from G-CSF and from CXCR4 Inhibition

Blood2018-11-292 citations

Plinabulin (Plin), a novel non-G-CSF molecule for the revention of chemotherapy-induced neutropenia (CIN), has the potential to positively impact tumor micro environment

Annals of Oncology2018-10-01

Plinabulin (Plin), a small molecule with anti-cancer activity and a novel mechanism of action (MoA) in docetaxel (Tax)-induced neutropenia: Phase (φ) 2 results from a head-to-head comparison with Pegfilgrastim (Peg).

Journal of Clinical Oncology2018-05-20

D5W Placebo

Sponsors

Conditions

Phase 2

Phase 3

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