D007262

13 trials

Sponsors

Hida Yasuhiro, HISAHARA SHIN, Ikeda Sadakatsu, Terai Shuji, Doi Kento

Conditions

Acute Kidney Injury Due to SepsisAcute non-embolic ischemic stroke Lacunar stroke, Non-embolic, Acute, Ischemic strokeAmyotrophic Lateral Sclerosis (ALS) Amyotrophic Lateral Sclerosis, ALSCerebral Autosomal Dominant Arteriopathy with Subcortical Infarct and Leukoencephalopathy (CADASIL) adrenomedullin, CADASIL, NOTCH3 geneChronic liver disease - Liver cirrhosis (alcoholic, non-alcoholic, HBV, or HCV)Esophageal cancer with EGFR amplification / Gastric cancer with EGFR amplificationMembranous nephropathy Glomerulonephritis, MembranousMetastatic Adenocarcinoma of the Pancreas Pancreatic cancer

Phase 1

Safety Evaluation Study of Pitavastatin PLGA nano-particle for Retinitis Pigmentosa

Active, not recruitingJPRN-jRCT2071260006

Murakami YusukeRetinitis Pigmentosa retina, degeneration

Start: 2026-06-01Target: 21Updated: 2026-06-29

Phase 2

A phase II study for HER2 amplified advanced solid tumors (JUPITER trial)

Active, not recruitingJPRN-jRCT2031180150

Ikeda SadakatsuSolid tumors HER2, solid tumor

Start: 2019-04-11Target: 38Updated: 2026-06-29

Adrenomedullin for ischemic stroke study

Active, not recruitingJPRN-jRCT2051190092

IHARA MASAFUMIAcute non-embolic ischemic stroke Lacunar stroke, Non-embolic, Acute, Ischemic stroke

Start: 2020-01-16Target: 60Updated: 2026-06-29

Intravenous infusion of autologous mesenchymal stem cells from bone marrow for ALS patients: double-blind randomized controlled trial

Active, not recruitingJPRN-jRCT2013190010

HISAHARA SHINAmyotrophic Lateral Sclerosis (ALS) Amyotrophic Lateral Sclerosis, ALS

Start: 2020-09-25Target: 40Updated: 2026-06-29

A phase II study of S-005151 in patients with chronic liver disease

Active, not recruitingJPRN-jRCT2031200232

Terai ShujiChronic liver disease - Liver cirrhosis (alcoholic, non-alcoholic, HBV, or HCV)

Start: 2020-12-10Target: 10Updated: 2026-06-29

Adrenomedullin for CADASIL

Active, not recruitingJPRN-jRCT2051210117

Ihara MasafumiCerebral Autosomal Dominant Arteriopathy with Subcortical Infarct and Leukoencephalopathy (CADASIL) adrenomedullin, CADASIL, NOTCH3 gene

Start: 2022-01-06Target: 60Updated: 2026-06-29

Extension study for HER2 amplified advanced solid tumors (JUPITER ES)

Active, not recruitingJPRN-jRCTs031220444

Ikeda SadakatsuSolid tumors HER2, solid tumor

Start: 2022-12-26Target: 3Updated: 2026-06-29

A study of irinotecan liposome injection, oxaliplatin, 5-fluorouracil/levoleucovorin in Japanese participants that have not been treated for pancreatic cancer that has spread (metastatic)

Active, not recruitingJPRN-jRCT2031230733

Fernandez Martin LourdesMetastatic Adenocarcinoma of the Pancreas Pancreatic cancer

Start: 2024-03-31Target: 41Updated: 2025-07-18

A Phase 2 Study of Necitumumab in Patients with Unresectable, Advanced or Recurrent Esophageal Cancer or Gastric Cancer with EGFR Amplification

RecruitingJPRN-jRCT2031240655

Kawai YukiEsophageal cancer with EGFR amplification / Gastric cancer with EGFR amplification

Start: 2025-06-11Target: 34Updated: 2026-06-29

Safety and Efficacy Study of Sivelestat in Neuromyelitis Optica Spectrum Disorder

Active, not recruitingJPRN-jRCT2071260028

Watanabe MitsuruNeuromyelitis Optica Spectrum Disorder (NMOSD) Optic neuritis, Myelitis, Anti-AQP4 antibody

Start: 2026-08-01Target: 7Updated: 2026-06-29

Phase 3

Prevention of metastasis by an ultra-short acting and the most selective beta1 blocker, Landiolol

Active, not recruitingJPRN-jRCT2011180004

Hida Yasuhironon-small cell lung cancer non-small cell lung cancer

Start: 2019-01-23Target: 400Updated: 2026-06-29

Recombinant human alkaline phosphatase SA-AKI survival trial

Active, not recruitingJPRN-jRCT2031210141

Doi KentoAcute Kidney Injury Due to Sepsis

Start: 2021-06-25Target: 98Updated: 2026-06-29

RecruitingJPRN-jRCT2041230037

Akihito TanakaMembranous nephropathy Glomerulonephritis, Membranous

Start: 2023-06-24Target: 88Updated: 2026-06-29

Related Papers

Safety and efficacy profile of S-005151 (Redasemtide), in patients with chronic liver diseases: phase 2 trial

Inflammation and Regeneration2026-05-09

Randomised, double-blind study to evaluate the efficacy of rituximab in the treatment of idiopathic membranous nephropathy: A clinical trial protocol

PLoS ONE2025-03-18

NALIRIFOX in Japanese treatment-naïve patients with metastatic pancreatic adenocarcinoma: an open-label, phase II trial design

Future Oncology2025-02-22

Efficacy and safety of adrenomedullin for acute ischemic stroke (AMFIS): a phase 2, randomized, double-blinded, placebo-controlled, clinical trial.

2024-11-133 citations

A multicenter, single-arm, phase II clinical trial of adrenomedullin in patients with cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy

Cerebral Circulation - Cognition and Behavior2024-01-014 citations

Primary results from JUPITER, a phase 2 basket trial of combination therapy with trastuzumab and pertuzumab in patients with HER2-amplified solid tumors.

Journal of Clinical Oncology2022-06-014 citations

A phase 2 basket trial of combination therapy with trastuzumab and pertuzumab in patients with solid cancers harboring HER2 amplification (JUPITER trial).

Journal of Clinical Oncology2021-05-202 citations

A phase 2 basket trial of combination therapy with trastuzumab and pertuzumab in patients with solid cancers harboring human epidermal growth factor receptor 2 amplification (JUPITER trial)

Medicine2020-08-0412 citations

Landiolol, an ultra-short acting beta-1 blocker, for preventing postoperative lung cancer recurrence: study protocol for a phase III, multicenter randomized trial with two parallel groups of patients.

2019-12-118 citations