CytoSorb

DEVICE20 trials

Sponsors

Medical University of Vienna, CytoSorbents, Inc, University Medical Centre Ljubljana, Centre Hospitalier Universitaire Vaudois, Technical University of Munich

Conditions

Acute Liver FailureAcute Respiratory Distress SyndromeAcute on Chronic Liver FailureAcute-On-Chronic Liver FailureAneurysmal Subarachnoid HaemorrhageAnticoagulant Adverse ReactionBlood Loss, PostoperativeBlood Loss, Surgical

Phase 1

Cytokine Clearance With Cytoabsorbant Device During Cardiac Bypass

CompletedNCT02775123

Centre Hospitalier Universitaire VaudoisHeart Valve Diseases, Myocardial Ischemia

Start: 2016-05-31End: 2018-01-31Updated: 2018-01-25

Phase 3

Cytokine Removal in Cardiopulmonary Bypass Patients

CompletedNCT01879176

Medical University of ViennaElective Cardiac Surgical Interventions

Start: 2013-08-31End: 2015-05-31Updated: 2017-02-23

Extracorporeal Cytokine Adsorption in Cardiac Surgery

CompletedNCT02666703

University Medical Centre LjubljanaCardiopulmonary Bypass

Start: 2016-02-01End: 2018-06-30Updated: 2020-03-25

Phase 4

Pancreatitis CytoSorbents (CytoSorb®) Inflammatory Cytokine Removal

Technical University of MunichPancreatitis, Acute, SIRS

Start: 2017-03-15End: 2018-07-31Target: 30Updated: 2017-03-17

Unknown Phase

CytoSorb Reduction of Free Hemoglobin During Cardiac Surgery

CompletedNCT02566525

CytoSorbents, IncElective Cardiac Surgery

Start: 2015-11-30End: 2016-12-31Updated: 2021-08-20

CytoSorb® Reduction of FREee Hemoglobin/Acute Kidney Injury (AKI) During Cardiac Surgery

TerminatedNCT03384875

CytoSorbents, IncElective Cardiac Surgery

Start: 2018-04-19End: 2022-01-18Updated: 2024-12-04

Does Whole Blood Adsorber During CPB Reduce Vasoactive Drugs Postoperatively in Endocarditis Patients Undergoing Valve Surgery?

CompletedNCT03945708

Emma HanssonInfective Endocarditis

Start: 2019-05-15End: 2020-12-31Updated: 2021-09-22

Extracorporeal Cytokine Adsorption as Additive Treatment of CAR-T Associated Cytokine Release Syndrome (CRS)

Hannover Medical SchoolCAR-T, Cytokine Release Syndrome

Start: 2021-06-30End: 2024-09-30Target: 34Updated: 2021-04-01

Hemadsorption During and After Cardiopulmonary Bypass to Modulate the Inflammatory Response

University Magna GraeciaCardiac Surgery, Chronic Renal Disease, Inflammatory Response

Start: 2020-11-15End: 2021-11-15Target: 40Updated: 2020-11-12

Determination of the Hemoadsorption Impact as Adjunctive Treatment Upon the Support Therapy of COVID-19

CompletedNCT04518969

Dr David DE BELSCovid19

Start: 2020-05-03End: 2021-09-16Updated: 2022-03-04

Effects of Renal Replacement Therapy With Hemoadsoption in Patients With Sepsis

CompletedNCT04533256

Institutul Clinic FundeniSepsis

Start: 2016-07-10End: 2021-07-30Updated: 2021-09-13

Cytokine Filter Usage During Open Thoracoabdominal Aortic Aneurysm Repair- a Single-center Randomized Prospective Trial

CompletedNCT04765748

RWTH Aachen UniversityInflammatory Response, Postoperative Complications

Start: 2021-02-11End: 2022-12-27Updated: 2024-04-10

ECMOsorb Trial - Impact of a VA-ECMO in Combination With CytoSorb in Critically Ill Patients With Cardiogenic Shock

CompletedNCT05027529

Christian SchulzeCardiogenic Shock

Start: 2021-05-21End: 2025-12-31Updated: 2026-02-04

Safe and Timely Antithrombotic Removal (STAR) Registry

RecruitingNCT05077124

CytoSorbents, IncBlood Loss, Postoperative, Blood Loss, Surgical, Hemorrhage Postoperative +1

Start: 2021-09-30End: 2025-09-30Target: 1000Updated: 2025-07-16

CytOSorb TreatMent Of Critically Ill PatientS Registry

RecruitingNCT05146336

CytoSorbents, IncAcute Liver Failure, Acute on Chronic Liver Failure, Acute Respiratory Distress Syndrome +15

Start: 2022-06-22End: 2032-09-30Target: 3000Updated: 2025-09-11

Cytokine Adsorption in Lung Transplantation

CompletedNCT05242289

Lund University HospitalLung Transplant; Complications, Lung Transplant Failure

Start: 2022-03-02End: 2023-08-30Updated: 2023-09-08

CytoSorb SAH Trial

TerminatedNCT05259514

Emanuela KellerAneurysmal Subarachnoid Haemorrhage

Start: 2022-01-31End: 2022-06-16Updated: 2022-08-08

Hemodynamic Impact of Cytosorb and CKRT in Children With Septic Shock

CompletedNCT05658588

Ospedale Pediatrico Bambin GesùSeptic Shock

Start: 2019-09-01End: 2021-10-01Updated: 2022-12-21

COOLEY- Study: aCute On chrOnic Liver failurE Using the cYtosorb Device

RecruitingNCT06079021

University Hospital, AntwerpAcute-On-Chronic Liver Failure, Anticoagulant Adverse Reaction, Sarcopenia +1

Start: 2024-06-08End: 2027-12-31Target: 20Updated: 2026-05-01

Hemoadsorpion in Patients With Septic Shock: Efficacy and Safety Evaluation

Not yet recruitingNCT07661303

Moscow Multidisciplinary Clinical Center "Kommunarka"Septic Shock

Start: 2026-06-25End: 2027-12-25Target: 76Updated: 2026-07-02

Related Papers

The international, prospective COSMOS (CytOSorb® TreatMent Of Critically Ill PatientS) Registry: results from the first 300 patients

Journal of Anesthesia Analgesia and Critical Care2026-02-25

Intraoperative antithrombotic drug removal during heart transplantation: A case series from the International Safe and Timely Antithrombotic Removal (STAR) registry.

2025-08-20

The international, prospective CytOSorb<sup>Ⓡ</sup> treatMent Of critically ill patientS (COSMOS) registry: Interim results from the first 150 patients.

2025-06-27

Early CABG with intraoperative hemoadsorption in patients on ticagrelor: Real-world data from the international Safe and Timely Antithrombotic Removal (STAR) registry

Cardiovascular revascularization medicine2025-02-281 citations

Direct-acting oral anticoagulant removal by intraoperative hemoadsorption in CABG and/or single valve surgery: interim analysis of the International Safe and Timely Antithrombotic Removal (STAR) registry

Journal of Cardiothoracic Surgery2025-01-201 citations

The COSMOS Registry of CytoSorb Hemoadsorption Therapy in Critically Ill Patients: Protocol for an International, Prospective Registry

JMIR Research Protocols2024-08-167 citations

The Sublingual Microcirculation in Critically Ill Children with Septic Shock Undergoing Hemoadsorption: A Pilot Study

Biomedicines2024-06-272 citations

Intraoperative haemoadsorption for antithrombotic drug removal during cardiac surgery: initial report of the international safe and timely antithrombotic removal (STAR) registry.

2024-05-0612 citations

Design and Rationale of Cytokine Filtration in Lung Transplantation (GLUSorb): Protocol for a Multicenter Clinical Randomized Controlled Trial

JMIR Research Protocols2023-10-024 citations

Impact of CytoSorb and CKRT on hemodynamics in pediatric patients with septic shock: the PedCyto study

Frontiers in Pediatrics2023-09-1516 citations

Influence of hemoadsorption during cardiopulmonary bypass on blood vesicle count and function.

2020-05-1512 citations

Extracorporeal Hemadsorption <i>versus</i> Glucocorticoids during Cardiopulmonary Bypass: A Prospective, Randomized, Controlled Trial

Cardiovascular Therapeutics2020-03-3042 citations

Extracorporeal cytokine removal in severe CAR-T cell associated cytokine release syndrome.

2020-02-1932 citations

Cytokine clearance with CytoSorb® during cardiac surgery: a pilot randomized controlled trial.

2019-04-0396 citations

Pancreatitis cytosorbents (CytoSorb) inflammatory cytokine removal

Medicine2019-01-0124 citations

Effect of hemoadsorption during cardiopulmonary bypass surgery – a blinded, randomized, controlled pilot study using a novel adsorbent

Critical Care2016-04-09167 citations