CYCLOPHOSPHAMIDE MONOHYDRATE
Sponsors
Novartis Pharma AG, CanCell Therapeutics, Nationwide Childrens Hospital, Nationwide Childrens Hospital, Celgene Corp., Istituto Europeo Di Oncologia S.r.l.
Conditions
ANCA-associated Vasculitis (AAV)Acute lymphoblastic leukemiaAdult patients with follicular B-cell non-Hodgkin lymphoma grade 1-3AAdvanced Stage of Hodgkin LymphomaChronic lymphocytic leukemia/Small lymphocytic lymphomaDiffuse large B-Cell lymphomaHigh-Risk large B-Cell lymphomaHigh-risk Large B-cell Lymphoma
Phase 1
An adaptive open-label multicentre phase 1/2 trial, to determine the recommended phase 2 dose of CCTx-001, and to assess safety, tolerability, and clinical activity in patients with relapsed/refractory acute myeloid leukaemia (RESOLVE AML 001)
Not yet recruitingCTIS2023-506865-71-00
Target: 61Updated: 2024-09-27
Phase I/II, open label, multicenter study of rapcabtagene autoleucel in adult patients with CLL/SLL, 3L+ DLBCL, r/r ALL and 1L HR LBCL
Active, not recruitingCTIS2023-507062-34-00
Start: 2020-08-07Target: 142Updated: 2025-11-12
Phase 2
A Pilot and Surgical Study of Larotrectinib for Treatment of Children with Newly Diagnosed High-Grade Glioma with NTRK Fusion
RecruitingCTIS2023-508953-16-00
Start: 2024-10-25Target: 5Updated: 2024-12-12
AZALEA: A Phase II study of atezolizumab, vinorelbine and weekly cyclophosphamide as T-cell activators in first line metastatic triple negative breast cancer patients pre-treated with anti-PD-L1/PD-1
RecruitingCTIS2024-514031-20-00
Start: 2025-02-24Target: 45Updated: 2025-04-14
A Phase 2 Study of Isatuximab in combination with Bortezomib, Cyclophosphamide and Dexamethasone followed by isatuximab and lenalidomide maintenance in Newly Diagnosed Patients with Multiple Myeloma and severe Renal Impairment
CompletedCTIS2024-516061-36-00
Start: 2022-07-28End: 2025-07-03Target: 51Updated: 2025-03-21
Phase 3
A randomized, open-label, multi-center phase III trial comparing tisagenlecleucel to standard of care in adult participants with relapsed or refractory follicular lymphoma
Active, not recruitingCTIS2023-503452-27-00
Start: 2024-01-02Target: 64Updated: 2025-04-30
A Phase 3, Multicenter, Randomized, Double-blind, Placebo-controlled Study Comparing the Efficacy and Safety of Golcadomide Plus R-CHOP Chemotherapy vs Placebo Plus R-CHOP Chemotherapy in Participants with Previously Untreated High-risk Large B-cell Lymphoma
(GOLSEEK-1)
Active, not recruitingCTIS2023-510178-15-00
Start: 2024-07-31Target: 322Updated: 2025-09-10
HD21 for advanced stages - Treatment optimization trial in the first-line treatment of advanced stage Hodgkin lymphoma; comparison of 4-6 cycles of escalated BEACOPP with 4-6 cycles of BrECADD
CompletedCTIS2024-518022-33-00
Start: 2016-07-15End: 2024-12-01Target: 1320Updated: 2024-11-19
A Phase 3, Open-label, Uncontrolled Single-arm Study to Evaluate the Efficacy, Pharmacokinetics, and Safety of Avacopan in Combination With a Rituximab or a Cyclophosphamide-containing Regimen in Children from 6 Years to < 18 Years of Age with Active ANCA-associated Vasculitis (AAV)
RecruitingCTIS2024-514779-16-00
Start: 2025-02-11Target: 11Updated: 2026-01-15
A Global Multicenter, Open Label, Randomized Phase III Confirmatory Study of Lisaftoclax (APG-2575) in Combination with Acalabrutinib versus Immunochemotherapy in Patients with Newly Diagnosed Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma (GLORA-2 Study)
RecruitingCTIS2024-514084-26-00
Start: 2025-08-22Target: 29Updated: 2025-07-31