Cyclophosphamide + Fludarabine Lymphodepletive Conditioning

DRUG2 trials

Sponsors

University of Florida, East Metropolitan Health Service, Australia

Conditions

Brain Stem GliomaDiffuse Intrinsic Pontine Glioma (DIPG)Melanoma (Skin Cancer)Melanoma Metastatic

Phase 1

Brain Stem Gliomas Treated With Adoptive Cellular Therapy During Focal Radiotherapy Recovery Alone or With Dose-intensified Temozolomide (Phase I)

TerminatedNCT03396575

University of FloridaBrain Stem Glioma, Diffuse Intrinsic Pontine Glioma (DIPG)

Start: 2018-07-17End: 2025-03-20Updated: 2025-10-29

Phase 2

A Phase II Trial of Tumour Infiltrating Lymphocyte Adoptive Cell Therapy in Patients With Immune Checkpoint Inhibitor Resistant Unresectable or Metastatic Melanoma

Not yet recruitingNCT07651618

East Metropolitan Health Service, AustraliaMelanoma Metastatic, Melanoma (Skin Cancer)

Start: 2026-07-01End: 2032-04-01Target: 10Updated: 2026-06-16