CSL112

BIOLOGICAL3 trials

Sponsors

CSL Limited, CSL Behring

Conditions

Acute Myocardial InfarctionHealthy

Phase 1

A Multiple Ascending Dose Study of CSL112 in Healthy Volunteers

CompletedNCT01281774

CSL LimitedHealthy

Start: 2011-01-31End: 2011-06-30Updated: 2012-03-07

A Study of CSL112 in Healthy Adults and in Adults With Moderate Renal Impairment

CompletedNCT02427035

CSL BehringAcute Myocardial Infarction

Start: 2015-05-31End: 2016-02-29Updated: 2017-09-19

Phase 2

A Phase 2b Study of CSL112 in Subjects With Acute Myocardial Infarction.

CompletedNCT02108262

CSL BehringAcute Myocardial Infarction

Start: 2014-08-31End: 2016-03-31Updated: 2021-03-15

Related Papers

CSL112 Infusion Rapidly Increases APOA1 Exchange Rate via Specific Serum Amyloid-Poor HDL Subpopulations When Administered to Patients Post–Myocardial Infarction

Arteriosclerosis Thrombosis and Vascular Biology2023-03-3012 citations

Safety and Tolerability of CSL112, a Reconstituted, Infusible, Plasma-Derived Apolipoprotein A-I, After Acute Myocardial Infarction

Circulation2016-11-16180 citations

Rationale and design of Apo-I Event Reduction in Ischemic Syndromes I (AEGIS-I): A phase 2b, randomized, placebo-controlled, dose-ranging trial to investigate the safety and tolerability of CSL112, a reconstituted, infusible, human apoA-I, after acute myocardial infarction.

2016-07-0526 citations

Abstract 17135: Distribution of Anti-oxidative Activity During Remodeling of High Density Lipoprotein: Studies With CSL112

Circulation2015-11-10

Abstract 17107: Distribution of Anti-inflammatory Activity During Remodeling of High Density Lipoprotein: Studies With CSL112

Circulation2015-11-10

Infusion of Reconstituted High‐Density Lipoprotein, CSL112, in Patients With Atherosclerosis: Safety and Pharmacokinetic Results From a Phase 2a Randomized Clinical Trial

Journal of the American Heart Association2015-08-25112 citations

A multiple ascending dose study of CSL112, an infused formulation of ApoA‐I

The Journal of Clinical Pharmacology2013-10-1284 citations