Cryoprecipitate

DRUG12 trials

Sponsors

CSL Behring, University of Sao Paulo, Weill Medical College of Cornell University, Gold Coast Hospital and Health Service, Stanford University

Conditions

Acquired Fibrinogen DeficiencyAfibrinogenemiaBleedingBlood Coagulation DisordersCardiac Surgical ProceduresCoagulopathyCongenital Heart DiseaseCryoprecipitate

Phase 2

Fibrinogen Concentrate In Children After Cardiac Surgery

CompletedNCT01187225

University of Sao PauloBlood Coagulation Disorders, Cardiac Surgical Procedures, Cryoprecipitate +1

Start: 2010-08-31End: 2011-11-30Updated: 2013-01-04

Fibrinogen Early In Severe Trauma studY

CompletedNCT02745041

Gold Coast Hospital and Health ServiceCoagulopathy, Haemorrhage, Trauma

Start: 2016-12-31End: 2018-02-20Updated: 2018-03-05

Fibrinogen Early In Severe Trauma studY Junior

Gold Coast Hospital and Health ServiceCoagulopathy, Hemorrhage, Pediatrics +1

Start: 2018-07-01End: 2021-06-30Target: 44Updated: 2020-06-29

Phase 3

Fibrinogen Concentrate (Human) - Efficacy and Safety Study

WithdrawnNCT00916656

CSL BehringAfibrinogenemia, Fibrinogen Deficiency, Hypofibrinogenemia

Start: 2009-10-31End: 2014-03-31Updated: 2023-02-06

FIBrinogen REplenishment in Surgery

CompletedNCT03037424

University Health Network, TorontoDeficiency; Fibrinogen, Acquired

Start: 2017-02-22End: 2019-03-27Updated: 2019-05-14

In Vivo Effects of Fibrinogen Concentrate (FC) Versus Cryoprecipitate on the Neonatal Fibrin Network Structure After Cardiopulmonary Bypass (CPB)

CompletedNCT03932240

Emory UniversityHemostasis

Start: 2019-08-13End: 2021-11-16Updated: 2024-02-20

Early Use of Cryoprecipitate With Major Hemorrhage Protocol (MHP) Activation

CompletedNCT04704869

Bryan CottonTrauma Injury

Start: 2017-01-31End: 2022-11-01Updated: 2025-01-14

Fibrinogen Early In Severe Trauma StudY II

RecruitingNCT05449834

Australian and New Zealand Intensive Care Research CentreCoagulopathy, Haemorrhagic Shock, Trauma

Start: 2022-11-21End: 2026-12-01Target: 900Updated: 2026-02-05

Phase 3 Study of Fibrinogen Concentrate (CSL511) in Subjects With Pseudomyxoma Peritonei Undergoing Cytoreductive Surgery

RecruitingNCT06617897

CSL BehringAcquired Fibrinogen Deficiency

Start: 2024-10-01End: 2027-10-29Target: 90Updated: 2026-03-11

Phase 4

Fibrinogen Concentrate vs Cryoprecipitate

CompletedNCT03014700

Stanford UniversityCongenital Heart Disease

Start: 2016-03-31End: 2018-04-25Updated: 2019-05-07

Comparison of Fibrinogen Concentrate and Cryoprecipitate in Pediatric Cardiac Surgery Patients

CompletedNCT04376762

University of VirginiaBleeding, Pediatric HD

Start: 2021-10-26End: 2023-05-01Updated: 2026-03-06

Unknown Phase

Trial of RiaSTAP Versus Cryoprecipitate to Lower Operative Transfusions

TerminatedNCT02540434

Weill Medical College of Cornell UniversityCoagulopathy

Start: 2015-10-31End: 2017-12-31Updated: 2019-01-15

Related Papers

Fibrinogen concentrate versus cryoprecipitate for bleeding in cardiac surgery patients stratified by surgery risk in the phase 3 fibres Study

Blood2025-11-03

Integrating Research Practice Into Resuscitation Simulation Training Improves Recruitment Into Complex Clinical Trials

Emergency Medicine Australasia2025-05-271 citations

Effect of In Vivo Administration of Fibrinogen Concentrate Versus Cryoprecipitate on Ex Vivo Clot Degradation in Neonates Undergoing Cardiac Surgery

Anesthesia & Analgesia2024-08-086 citations

Early and Empirical High-Dose Cryoprecipitate for Hemorrhage After Traumatic Injury

JAMA2023-10-12107 citations

Cryoprecipitate transfusion in trauma patients attenuates hyperfibrinolysis and restores normal clot structure and stability: Results from a laboratory sub-study of the FEISTY trial.

2022-09-2615 citations

Impact of cardiopulmonary bypass duration on efficacy of fibrinogen replacement with cryoprecipitate compared with fibrinogen concentrate: a post hoc analysis of the Fibrinogen Replenishment in Surgery (FIBRES) randomised controlled trial

British Journal of Anaesthesia2022-06-2813 citations

Weight-adjusted dosing of fibrinogen concentrate and cryoprecipitate in the treatment of hypofibrinogenaemic bleeding adult cardiac surgical patients: a <i>post hoc</i> analysis of the Fibrinogen Replenishment in cardiac surgery randomised controlled trial.

2022-06-09

Fibrinogen Early In Severe paediatric Trauma studY (FEISTY junior): protocol for a randomised controlled trial

BMJ Open2022-05-016 citations

Effect of Fibrinogen Concentrate vs Cryoprecipitate on Blood Component Transfusion After Cardiac Surgery

JAMA2019-10-21158 citations

Fibrinogen Concentrate Vs. Cryoprecipitate for Acquired Hypofibrinogenemia in Cardiac Surgery — the FIBRES Study

Blood2018-11-29

Early fibrinogen concentrate therapy for major haemorrhage in trauma (E-FIT 1): results from a UK multi-centre, randomised, double blind, placebo-controlled pilot trial

Critical Care2018-06-18100 citations

Protocol for a phase III, non-inferiority, randomised comparison of a new fibrinogen concentrate versus cryoprecipitate for treating acquired hypofibrinogenaemia in bleeding cardiac surgical patients: the FIBRES trial

BMJ Open2018-04-0123 citations

Fibrinogen Early In Severe Trauma studY (FEISTY): study protocol for a randomised controlled trial.

2017-05-2643 citations