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COVID-19 convalescent plasma

BIOLOGICAL11 trials

Sponsors

Mayo Clinic, University of Colorado, Denver, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Pontificia Universidad Catolica de Chile, University of Pennsylvania

Conditions

COVID-19COVID19Coronavirus Disease 2019 (COVID-19)Coronavirus Disease 2019 )COVID-19)Coronavirus InfectionsCovid-19SARS-CoV 2SARS-CoV Infection

Phase 1

COVID-19 Convalescent Plasma for Mechanically Ventilated Population
CompletedNCT04388527
University of PennsylvaniaCovid-19
Start: 2020-04-30End: 2021-01-30Updated: 2022-04-04
COVID-19 Convalescent Plasma for the Treatment of Hospitalized Patients With Pneumonia Caused by SARS-CoV-2.
CompletedNCT04397757
University of PennsylvaniaCOVID-19
Start: 2020-05-13End: 2021-03-08Updated: 2022-04-19

Phase 2

Early transfusIon of Convalescent Plasma in Elderly COVID-19 Patients. to Prevent Disease Progression.
CompletedNCT04374526
Fondazione Policlinico Universitario Agostino Gemelli IRCCSCoronavirus Disease 2019 )COVID-19)
Start: 2020-05-27End: 2021-05-26Updated: 2021-05-28
Efficacy and Safety of Early COVID-19 Convalescent Plasma in Patients Admitted for COVID-19 Infection
CompletedNCT04375098
Pontificia Universidad Catolica de ChileSevere Acute Respiratory Syndrome Coronavirus 2
Start: 2020-05-04End: 2020-08-17Updated: 2020-09-16
Convalescent Plasma (PC) and Human Intravenous Anti-COVID-19 Immunoglobulin (IV Anti COVID-19 IgG) in Patients Hospitalized for COVID-19.
NCT04395170
Lifefactors Zona Franca, SASCoronavirus Disease 2019 (COVID-19)
Start: 2020-09-30End: 2021-06-30Target: 75Updated: 2020-07-10
ANTIBODY-LEVEL BASED ANALYSIS OF COVID-19 CONVALESCENT SERUM (ABACCuS)
TerminatedNCT04432272
Corewell Health EastCoronavirus Infections, COVID-19, Severe Acute Respiratory Syndrome (SARS)
Start: 2020-07-16End: 2020-11-28Updated: 2022-03-09
Assessment of Efficacy and Safety of Therapy With COVID-19 Convalescent Plasma in Subjects With Severe COVID-19 (IPCO)
NCT04712344
University of Erlangen-Nürnberg Medical SchoolSevere COVID-19
Start: 2021-01-18End: 2021-09-30Target: 58Updated: 2021-01-20

Unknown Phase

Expanded Access to Convalescent Plasma for the Treatment of Patients With COVID-19
NCT04338360
Mayo ClinicCOVID19
Updated: 2020-09-02
Convalescent Plasma for the Treatment of Patients With COVID-19
NCT04372368
University of Colorado, DenverCOVID-19, SARS-CoV 2
Updated: 2020-08-28
Investigational COVID-19 Convalescent Plasma Infusion for Severely or Life-threateningly Ill COVID-19 Patients
NCT04420988
Rutgers, The State University of New JerseyCOVID-19, SARS-CoV 2, SARS-CoV Infection
Updated: 2023-11-28
Observational Study of Convalescent Plasma for Treatment of Veterans With COVID-19
CompletedNCT04545047
VA Office of Research and DevelopmentCoronavirus Disease 2019 (COVID-19)
Start: 2020-05-01End: 2021-10-01Updated: 2024-04-04

Related Papers

Cardiac troponin T elevation predicts mortality in hospitalized COVID-19 patients.
2025-12-02
Nucleocapsid-specific antibody function is associated with therapeutic benefits from COVID-19 convalescent plasma therapy.
2022-10-2424 citations
T cell receptor sequencing identifies prior SARS-CoV-2 infection and correlates with neutralizing antibodies and disease severity
JCI Insight2022-04-1945 citations
Access to and safety of COVID-19 convalescent plasma in the United States Expanded Access Program: A national registry study
PLoS Medicine2021-12-2065 citations
A randomized controlled study of convalescent plasma for individuals hospitalized with COVID-19 pneumonia
Journal of Clinical Investigation2021-11-1778 citations
Mortality in individuals treated with COVID-19 convalescent plasma varies with the geographic provenance of donors.
2021-08-1153 citations
Early Convalescent Plasma Therapy and Mortality Among US Veterans Hospitalized With Nonsevere COVID-19: An Observational Analysis Emulating a Target Trial
The Journal of Infectious Diseases2021-06-1918 citations
Passive Immunity Trial for Our Nation (PassITON): study protocol for a randomized placebo-control clinical trial evaluating COVID-19 convalescent plasma in hospitalized adults.
2021-03-2013 citations
Early versus deferred anti-SARS-CoV-2 convalescent plasma in patients admitted for COVID-19: A randomized phase II clinical trial
PLoS Medicine2021-03-0393 citations
Convalescent Plasma Antibody Levels and the Risk of Death from Covid-19
New England Journal of Medicine2021-01-13539 citations
Matched Cohort Study of Convalescent COVID-19 Plasma Treatment in Severely or Life Threateningly Ill COVID-19 Patients
Open Forum Infectious Diseases2021-01-0411 citations
Treatment of immunocompromised COVID-19 patients with convalescent plasma.
2020-11-2944 citations
"Early transfusion of convalescent plasma in older patients with COVID-19 to prevent disease progression: A structured summary of a study protocol for a randomised controlled trial".
2020-10-225 citations
Early safety indicators of COVID-19 convalescent plasma in 5000 patients
Journal of Clinical Investigation2020-06-11478 citations