Cotrimoxazole

DRUG16 trials

Conditions

Acquired Immunodeficiency SyndromeAnemiaAntibiotic Side EffectAscitesBacteriuriaChild DevelopmentChildhood PneumoniaColitis, Ulcerative

Phase 2

VSL#3 and Spontaneous Bacterial Peritonitis

TerminatedNCT01701297

Nottingham University Hospitals NHS TrustAscites, Decompensated Cirrhosis

Start: 2012-02-29End: 2014-10-31Updated: 2016-10-28

Administration of Antibiotic Prophylaxis for Transperineal Prostate Biopsy in Cipto Mangunkusumo Hospital

NCT04985110

Indonesia UniversityBacteriuria, Perioperative Complication, Prostate Biopsy +3

Start: 2021-07-06End: 2023-07-06Target: 78Updated: 2021-08-05

Phase 3

Isoniazid Prophylaxis With Concomitant Cotrimoxazole in HIV-infected Children

CompletedNCT00330304

University of Cape TownTuberculosis

Start: 2003-01-31End: 2011-11-15Updated: 2019-04-22

Cotrimoxazole Versus Vancomycin for Invasive Methicillin-resistant Staphylococcus Aureus Infections

CompletedNCT00427076

Rabin Medical CenterMeningitis, Pneumonia, Sepsis +1

Start: 2007-06-30End: 2014-06-30Updated: 2015-09-25

Daily Co-trimoxazole Prophylaxis to Prevent Malaria in Pregnancy

TerminatedNCT00711906

Institute of Tropical Medicine, BelgiumMalaria in Pregnancy

Start: 2009-02-28End: 2010-09-30Updated: 2016-01-18

Cotrimoxazole Versus Amoxicillin in the Treatment of Community Acquired Pneumonia in Children Aged 2-59 Months

CompletedNCT00933049

Makerere UniversityChildhood Pneumonia

Start: 2007-07-31End: 2008-01-31Updated: 2009-07-07

Prevention of Pregnancy-associated Malaria in HIV-infected Women: Cotrimoxazole Prophylaxis Versus Mefloquine

CompletedNCT00970879

Institut de Recherche pour le DeveloppementHIV Infections, Malaria in Pregnancy

Start: 2009-12-31End: 2012-12-31Updated: 2013-01-23

Study to Test the Validity of the Treatment of Idiopathic Pulmonary Fibrosis With Cotrimoxazole

TerminatedNCT01777737

Fundación Pública Andaluza para la gestión de la Investigación en SevillaIdiopathic Pulmonary Fibrosis

Start: 2013-11-25End: 2015-11-05Updated: 2017-11-14

COMBI Trial

Active, not recruitingPACTR202107707978619

Zvitambo Institute for Maternal and Child Health ResearchNeonatal Diseases Pregnancy and Childbirth

Start: 2021-09-13Target: 1000Updated: 2026-01-27

Efficacy of Cotrimoxazole as a De-escalation Treatment of Ventilator-Associated Pneumonia in Intensive Care Unit

RecruitingNCT05696093

Assistance Publique - Hôpitaux de ParisVentilator Associated Pneumonia

Start: 2023-10-19End: 2026-12-31Target: 628Updated: 2025-05-20

Hydroxyurea – Pragmatic Reduction in Mortality and Economic burden: A multi-centre Phase III trial to investigate the efficacy of hydroxyurea for children with sickle cell anaemia when administered in a pragmatic fashion.

RecruitingPACTR202401802272880

Imperial CollegeHaematological Disorders Malaria Bacterial infection Paediatrics

Start: 2023-09-01Target: 1800Updated: 2026-01-27

Phase 4

Cotrimoxazole Prophylaxis Cessation Study Among Stabilized HIV-Infected Adult Patients on HAART in Entebbe, Uganda

NCT00674921

MRC/UVRI and LSHTM Uganda Research UnitHIV Infections

Start: 2008-06-30End: 2011-06-30Target: 1650Updated: 2008-06-05

Safety of Cotrimoxazole in HIV- and HAART-exposed Infants

CompletedNCT01086878

Harvard School of Public Health (HSPH)Acquired Immunodeficiency Syndrome, Anemia, HIV Infections +2

Start: 2009-02-28End: 2010-10-31Target: 222Updated: 2011-02-25

Impact of Cotrimoxazole Use in Immunocompetent HIV Patients on Carriage of Antimicrobial Resistant Bacteria

CompletedNCT03087890

University of BergenAntibiotic Side Effect, HIV-1-infection, Opportunistic Infections +2

Start: 2017-03-30End: 2019-07-25Updated: 2019-10-02

Antibiotic Resistance and Microbiome in Children Aged 6-59 Months in Nouna, Burkina Faso

CompletedNCT03187834

University of California, San FranciscoChild Development

Start: 2017-07-04End: 2019-09-01Updated: 2023-03-02

Unknown Phase

Antibiotics for the Treatment of Ulcerative Colitis

CompletedNCT00355602

University of DundeeColitis, Ulcerative

Start: 2006-07-31End: 2008-12-31Target: 40Updated: 2009-02-11

New England Journal of Medicine2025-06-043 citations

Genetic determinants of macrolide and tetracycline resistance in penicillin non-susceptible Streptococcus pneumoniae isolates from people living with HIV in Dar es Salaam, Tanzania

Annals of Clinical Microbiology and Antimicrobials2023-02-204 citations

Antenatal and delivery practices and neonatal mortality amongst women with institutional and non-institutional deliveries in rural Zimbabwe: observational data from a cluster randomized trial.

2022-12-302 citations

Predominance of PVL-negative community-associated methicillin-resistant Staphylococcus aureus sequence type 8 in newly diagnosed HIV-infected adults, Tanzania.

2021-02-147 citations

High rate of antimicrobial resistance and multiple mutations in the dihydrofolate reductase gene among Streptococcus pneumoniae isolated from HIV-infected adults in a community setting in Tanzania.

2020-07-0912 citations

Indirect effect of oral azithromycin on the gut resistome of untreated children: a randomized controlled trial

International Health2020-05-192 citations

Short-term weight gain among preschool children in rural Burkina Faso: a secondary analysis of a randomised controlled trial

BMJ Open2019-07-011 citations

Indirect Effect of Azithromycin Use on the Intestinal Microbiome Diversity of Untreated Children: A Randomized Trial

Open Forum Infectious Diseases2019-02-066 citations

Effect of Commonly Used Pediatric Antibiotics on Gut Microbial Diversity in Preschool Children in Burkina Faso: A Randomized Clinical Trial

Open Forum Infectious Diseases2018-11-0158 citations

Trimethoprim-sulfamethoxazole versus vancomycin for severe infections caused by meticillin resistant Staphylococcus aureus: randomised controlled trial

BMJ2015-05-14151 citations

Incidence of malaria-related fever and morbidity due to Plasmodium falciparum among HIV1-infected pregnant women: a prospective cohort study in South Benin.

2014-07-042 citations

Safety of Daily Co-Trimoxazole in Pregnancy in an Area of Changing Malaria Epidemiology: A Phase 3b Randomized Controlled Clinical Trial

PLoS ONE2014-05-1522 citations

Cotrimoxazole Prophylaxis and Risk of Severe Anemia or Severe Neutropenia in HAART-Exposed, HIV-Uninfected Infants

PLoS ONE2013-09-2313 citations

Effectiveness of two antifolate prophylactic strategies against malaria in HIV-positive pregnant women in Bangui, Central African Republic: study protocol for a randomized controlled trial (MACOMBA).

2013-08-142 citations

The impact of isoniazid preventive therapy and antiretroviral therapy on tuberculosis in children infected with HIV in a high tuberculosis incidence setting.

2011-04-0239 citations

Adherence to isoniazid prophylaxis among HIV-infected children: a randomized controlled trial comparing two dosing schedules.

2009-11-0317 citations