Copper Gluconate

DRUG9 trials

Conditions

CancerChronic Liver DiseaseCirrhosisCopper DeficiencyFibrosisGlioblastomaGlioblastoma MultiformeInfection

Early Phase 1

Disulfiram in Treating Patients With Glioblastoma Multiforme After Radiation Therapy With Temozolomide

CompletedNCT01907165

Washington University School of MedicineGlioblastoma

Start: 2013-10-10End: 2018-02-09Updated: 2018-07-20

Phase 1

Phase I Study of Disulfiram and Copper Gluconate for the Treatment of Refractory Solid Tumors Involving the Liver

CompletedNCT00742911

University of UtahCancer

Start: 2008-07-31End: 2013-03-31Updated: 2014-10-31

Human Biomarkers for Assessing Copper Deficiency

NCT01177579

Purdue UniversityCopper Deficiency

Start: 2010-11-30End: 2018-12-31Target: 70Updated: 2017-04-19

Disulfiram/Copper With Concurrent Radiation Therapy and Temozolomide in Patients With Newly Diagnosed Glioblastoma

CompletedNCT02715609

Washington University School of MedicineGlioblastoma Multiforme

Start: 2016-06-15End: 2024-05-12Updated: 2025-04-10

A Phase Ib Study of Intravenous Copper Loading With Oral Disulfiram in Metastatic, Castration Resistant Prostate Cancer

TerminatedNCT02963051

Daniel George, MDProstate Cancer

Start: 2017-07-11End: 2020-02-01Updated: 2021-09-16

Study of Disulfiram and Copper Gluconate in Patients With Treatment-Refractory Multiple Myeloma

TerminatedNCT04521335

University of UtahMultiple Myeloma

Start: 2021-05-21End: 2022-02-06Updated: 2023-03-13

Disulfiram With Copper Gluconate and Liposomal Doxorubicin in Treatment-Refractory Sarcomas

RecruitingNCT05210374

Case Comprehensive Cancer CenterRelapsed Sarcomas

Start: 2023-03-09End: 2026-12-31Target: 24Updated: 2026-08-06

Phase 2

Disulfiram and Copper Gluconate With Temozolomide in Unmethylated Glioblastoma Multiforme

TerminatedNCT03363659

Wake Forest University Health SciencesGlioblastoma, Glioblastoma Multiforme

Start: 2018-03-28End: 2022-01-13Updated: 2024-10-03

Unknown Phase

Copper Supplementation in Cirrhosis

RecruitingNCT07471542

University of WashingtonChronic Liver Disease, Cirrhosis, Fibrosis +1

Start: 2026-03-15End: 2028-12-01Target: 30Updated: 2026-03-13

2022-11-156 citations

A Phase 1 dose-escalation study of disulfiram and copper gluconate in patients with advanced solid tumors involving the liver using S-glutathionylation as a biomarker

BMC Cancer2021-05-0745 citations

Disulfiram (DSF) pharmacokinetics (PK) and copper PET imaging in a phase Ib study of intravenous (IV) copper loading with oral DSF for patients with metastatic castration-resistant prostate cancer (mCRPC).

Journal of Clinical Oncology2020-02-198 citations

A TITE-CRM phase I/II study of disulfiram and copper with concurrent radiation therapy and temozolomide for newly diagnosed glioblastoma.

Journal of Clinical Oncology2019-05-2010 citations

Diethyldithiocarbamate complexes with metals used as food supplements show different effects in cancer cells

Journal of Applied Biomedicine2014-05-0421 citations