Consolidation Therapy

DRUG3 trials

Sponsors

City of Hope Medical Center, Institute of Hematology & Blood Diseases Hospital, China

Conditions

AML, AdultAcute Lymphoblastic Leukemia, AdultLocally Advanced Rectal AdenocarcinomaStage II Rectal Cancer AJCC v8Stage III Rectal Cancer AJCC v8

Phase 1

Papaverine in Combination With Radiation Therapy for the Treatment of Locally Advanced Rectal Cancer, DINOMITE Trial

RecruitingNCT06834126

City of Hope Medical CenterLocally Advanced Rectal Adenocarcinoma, Stage III Rectal Cancer AJCC v8, Stage II Rectal Cancer AJCC v8

Start: 2025-04-07End: 2028-09-19Target: 36Updated: 2025-07-18

Phase 3

VAG Versus Standard Chemotherapy With FLT3 Inhibitor in Adult Patients With FLT3-Mutated AML

Not yet recruitingNCT07407140

Institute of Hematology & Blood Diseases Hospital, ChinaAML, Adult

Start: 2026-04-30End: 2030-12-31Target: 300Updated: 2026-03-25

Unknown Phase

Pediatric-Inspired Regimen Combined With Venetoclax and Immunotherapy for Adult Ph-Negative Acute Lymphoblastic Leukemia

Not yet recruitingNCT07495631

Institute of Hematology & Blood Diseases Hospital, ChinaAcute Lymphoblastic Leukemia, Adult

Start: 2026-03-01End: 2030-03-01Target: 80Updated: 2026-03-27

Related Papers

Decreasing hypoxia with mitochondrial inhibition in locally advanced rectal cancer: Phase 1 trial of papaverine in combination with radiation (DINOMITE).

Journal of Clinical Oncology2026-01-10