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DRUG5 trials

Sponsors

Centre Hospitalier Universitaire De Nantes, Karyopharm Therapeutics Inc., Centre Hospitalier Universitaire Amiens Picardie, Assistance Publique Hopitaux De Paris, Centre Hospitalier Universitaire De Lille

Conditions

Adult patients with a diagnosis of fibrotic Hypersensitivity Pneumonitis (HP) (“definite” or “high confidence”) after multi-disciplinary discussion (MDD) with a mild to moderate disease severityAlcoholic hepatitisTreatment naïve patients with MFand never treated for fibrotic HP.kidney transplantationsuperficial arteriovenous malformations

Phase 2

MAV-RAPA: Prospective evaluation of the efficacy of sirolimus (Rapamune) in the treatment of superficial arteriovenous malformations.
Not yet recruitingCTIS2024-516001-23-00
Centre Hospitalier Universitaire Amiens Picardiesuperficial arteriovenous malformations
Target: 50Updated: 2025-01-17

Phase 3

A PHASE 1/3 STUDY TO EVALUATE THE EFFICACY AND SAFETY OF SELINEXOR, A SELECTIVE INHIBITOR OF NUCLEAR EXPORT, IN COMBINATION WITH RUXOLITINIB IN TREATMENT-NAÏVE PATIENTS WITH MYELOFIBROSIS
Active, not recruitingCTIS2023-506139-13-00
Karyopharm Therapeutics Inc.Treatment naïve patients with MF
Start: 2024-01-04Target: 195Updated: 2025-10-09
Prospective, multicenter, randomized, open-label, parallel-group controlled phase 3 study of tacrolimus minimization in kidney transplant recipients selected according to the AGORA algorithm for their low immunological risk and medium-term graft failure
RecruitingCTIS2022-502624-44-00
Centre Hospitalier Universitaire De Nanteskidney transplantation
Start: 2024-12-10Target: 343Updated: 2024-10-21
PROlonged Corticosteroid treatment or N-ACetylcysteine for severe alcoholic hepatitis (PROCORNAC)
Not yet recruitingCTIS2025-522109-39-00
Centre Hospitalier Universitaire De LilleAlcoholic hepatitis
Target: 477Updated: 2025-10-17
RUBY study « Randomized controlled trial testing the efficacy of corticosteroid therapy versus placebo in fibrotic hypersensitivity pneumonitis.»
Not yet recruitingCTIS2025-521591-64-00
Assistance Publique Hopitaux De ParisAdult patients with a diagnosis of fibrotic Hypersensitivity Pneumonitis (HP) (“definite” or “high confidence”) after multi-disciplinary discussion (MDD) with a mild to moderate disease severity, and never treated for fibrotic HP.
Target: 120Updated: 2026-08-03