Columvi 10 mg concentrate for solution for infusion
Sponsors
F. Hoffmann-La Roche AG, Pfizer Inc., Klinikum der Universitaet Muenchen AöR, Ryvu Therapeutics S.A., Frankfurter Institut Fuer Klinische Krebsforschung IKF GmbH
Conditions
Mantle Cell Lymphoma (MCL)Relapsed or Refractory Aggressive B-cell Non-Hodgkin LymphomaRelapsed or Refractory B-Cell MalignanciesRelapsed/Refractory B-Cell Non-Hodgkin’s Lymphoma (r/r B-cell NHL)Relapsed/Refractory Diffuse Large B Cell LymphomaRelapsed/refractory B-cell non-Hodgkin’s lymphoma (r/r NHL)previously untreated aggressive B-cell lymphoma
Phase 1
An Open-Label, Phase I/II Study to Evaluate the Safety, Pharmacokinetics and Preliminary Anti-Tumor Activity of Englumafusp Alfa (RO7227166, a CD19 Targeted 4-1BB Ligand) in Combination with Obinutuzumab and in Combination with Glofitamab Following a Pre-Treatment Dose of Obinutuzumab Administered in Participants with Relapsed/Refractory B-Cell Non-Hodgkin’s Lymphoma
RecruitingCTIS2022-502616-37-00
Start: 2019-07-30Target: 194Updated: 2025-11-25
A Multicenter, Open-Label, Phase I/II Study to Evaluate the Safety, Efficacy, Tolerability and Pharmacokinetics of Escalating Doses of Glofitamab (RO7082859) as a Single Agent and in Combination with Obinutuzumab Administered After a Fixed, Single Dose Pre-Treatment of Obinutuzumab (Gazyva®/Gazyvaro™) in Patients with Relapsed/Refractory B-Cell Non-Hodgkin’s Lymphoma
RecruitingCTIS2023-505625-14-00
Start: 2017-01-31Target: 459Updated: 2025-09-08
C4971006: A PHASE 1b/2, OPEN-LABEL STUDY OF PF-07901801 IN COMBINATION WITH GLOFITAMAB AFTER A FIXED, SINGLE DOSE OF OBINUTUZUMAB IN PARTICIPANTS WITH RELAPSED/REFRACTORY DIFFUSE LARGE B CELL LYMPHOMA NOT ELIGIBLE FOR STEM CELL TRANSPLANTATION
CompletedCTIS2022-502822-41-00
End: 2025-08-01Target: 34Updated: 2025-04-30
A Phase 1b/2, Open-Label, Master Protocol Study of BTK-Degrader BGB-16673 in Combination With Other Agents in Patients With Relapsed or Refractory B-Cell
Malignancies
RecruitingCTIS2024-516234-35-00
Start: 2025-10-15Target: 99Updated: 2026-01-14
Phase 2
An Open Label, Phase 2 Clinical Trial of MEN1703 as Monotherapy and in Combination with Glofitamab in Patients with Relapsed or Refractory Aggressive B-cell Non-Hodgkin Lymphoma (JASPIS-01)
RecruitingCTIS2024-513098-31-00
Start: 2024-11-14Target: 118Updated: 2025-11-25
A prospective multicenter phase 2 study of the chemotherapy-light combination of intravenous rituximab with the antibody-drug conjugate polatuzumab vedotin and the bispecific antibody glofitamab in previously untreated aggressive B-cell lymphoma patients above 60 years of age ineligible for a fully dosed R-CHOP
Active, not recruitingCTIS2024-513949-37-00
Start: 2023-03-16Target: 125Updated: 2024-11-13
Glofitamab Combined With Pirtobrutinib in Relapsed/Refractory Patients with Mantle Cell Lymphoma Followed by an Extension in Treatment Naïve Patients (PLATO)
RecruitingCTIS2024-512922-27-00
Start: 2025-11-25Target: 96Updated: 2025-11-18