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Columvi 10 mg concentrate for solution for infusion

DRUG7 trials

Sponsors

F. Hoffmann-La Roche AG, Pfizer Inc., Klinikum der Universitaet Muenchen AöR, Ryvu Therapeutics S.A., Frankfurter Institut Fuer Klinische Krebsforschung IKF GmbH

Conditions

Mantle Cell Lymphoma (MCL)Relapsed or Refractory Aggressive B-cell Non-Hodgkin LymphomaRelapsed or Refractory B-Cell MalignanciesRelapsed/Refractory B-Cell Non-Hodgkin’s Lymphoma (r/r B-cell NHL)Relapsed/Refractory Diffuse Large B Cell LymphomaRelapsed/refractory B-cell non-Hodgkin’s lymphoma (r/r NHL)previously untreated aggressive B-cell lymphoma

Phase 1

An Open-Label, Phase I/II Study to Evaluate the Safety, Pharmacokinetics and Preliminary Anti-Tumor Activity of Englumafusp Alfa (RO7227166, a CD19 Targeted 4-1BB Ligand) in Combination with Obinutuzumab and in Combination with Glofitamab Following a Pre-Treatment Dose of Obinutuzumab Administered in Participants with Relapsed/Refractory B-Cell Non-Hodgkin’s Lymphoma
RecruitingCTIS2022-502616-37-00
F. Hoffmann-La Roche AGRelapsed/Refractory B-Cell Non-Hodgkin’s Lymphoma (r/r B-cell NHL)
Start: 2019-07-30Target: 194Updated: 2025-11-25
A Multicenter, Open-Label, Phase I/II Study to Evaluate the Safety, Efficacy, Tolerability and Pharmacokinetics of Escalating Doses of Glofitamab (RO7082859) as a Single Agent and in Combination with Obinutuzumab Administered After a Fixed, Single Dose Pre-Treatment of Obinutuzumab (Gazyva®/Gazyvaro™) in Patients with Relapsed/Refractory B-Cell Non-Hodgkin’s Lymphoma
RecruitingCTIS2023-505625-14-00
F. Hoffmann-La Roche AGRelapsed/refractory B-cell non-Hodgkin’s lymphoma (r/r NHL)
Start: 2017-01-31Target: 459Updated: 2025-09-08
C4971006: A PHASE 1b/2, OPEN-LABEL STUDY OF PF-07901801 IN COMBINATION WITH GLOFITAMAB AFTER A FIXED, SINGLE DOSE OF OBINUTUZUMAB IN PARTICIPANTS WITH RELAPSED/REFRACTORY DIFFUSE LARGE B CELL LYMPHOMA NOT ELIGIBLE FOR STEM CELL TRANSPLANTATION
CompletedCTIS2022-502822-41-00
Pfizer Inc.Relapsed/Refractory Diffuse Large B Cell Lymphoma
End: 2025-08-01Target: 34Updated: 2025-04-30
A Phase 1b/2, Open-Label, Master Protocol Study of BTK-Degrader BGB-16673 in Combination With Other Agents in Patients With Relapsed or Refractory B-Cell Malignancies
RecruitingCTIS2024-516234-35-00
BeOne Medicines AGRelapsed or Refractory B-Cell Malignancies
Start: 2025-10-15Target: 99Updated: 2026-01-14

Phase 2