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Cocoa extract placebo

DIETARY_SUPPLEMENT6 trials

Sponsors

Brigham and Women's Hospital, Columbia University, Augusta University

Conditions

Age Related Macular DegenerationAgingCancerCardiovascular DiseaseCardiovascular DiseasesCataractCognitive ChangeFall

Phase 4

COcoa Supplement and Multivitamin Outcomes Study
CompletedNCT02422745
Brigham and Women's HospitalCancer, Cardiovascular Disease
Start: 2015-06-01End: 2023-06-05Updated: 2026-07-13
Cataract and AMD in a Trial of a Multivitamin and Cocoa Extract
NCT03205202
Brigham and Women's HospitalAge Related Macular Degeneration, Cataract
Start: 2015-06-01End: 2022-10-31Target: 21442Updated: 2021-09-17
Cocoa Supplementation, Inflammaging, and Epigenetic Aging
NCT05510375
Augusta UniversityAging, Cardiovascular Diseases, Inflammation
Start: 2015-06-30End: 2023-09-30Updated: 2022-08-22

Unknown Phase

Investigating the Effects of Cocoa Flavanol on Cognition Assessed Online
CompletedNCT04582617
Columbia UniversityAging, Cognitive Change
Start: 2016-08-26End: 2020-12-31Updated: 2023-04-07
COcoa Supplement and Multivitamin Outcomes Study: Effects on Falls and Physical Performance
Active, not recruitingNCT05232669
Brigham and Women's HospitalFall, Fracture, Physical Performance
Start: 2021-05-15End: 2027-02-01Updated: 2026-04-13
Cocoa Extract for Migraine Trial
RecruitingNCT06808230
Brigham and Women's HospitalMigraine
Start: 2025-06-23End: 2026-12-01Target: 114Updated: 2026-06-29

Related Papers

Effects of daily multivitamin-multimineral supplementation on metabolomic profiles: 2-year findings from the COSMOS randomized clinical trial.
2026-03-30
Long-term effect of multivitamin supplementation on incident self-reported hypertension and blood pressure changes in the COSMOS trial.
2025-11-20
The overlooked impact of background diet and adherence in nutrition trials.
2025-07-14
Cocoa Flavanol Supplementation and Risk of Age-Related Macular Degeneration
JAMA Ophthalmology2025-03-27
Effects of cocoa extract supplementation and multivitamin/multimineral supplements on self-reported fractures in the Cocoa Supplement and Multivitamins Outcomes Study randomized clinical trial
Journal of Bone and Mineral Research2025-02-182 citations
Effect of multivitamin-mineral supplementation versus placebo on cognitive function: results from the clinic subcohort of the COcoa Supplement and Multivitamin Outcomes Study (COSMOS) randomized clinical trial and meta-analysis of 3 cognitive studies within COSMOS.
2024-01-1817 citations
Effect of cocoa extract supplementation on cognitive function: results from the clinic subcohort of the COSMOS trial.
2023-12-075 citations
Dietary flavanols restore hippocampal-dependent memory in older adults with lower diet quality and lower habitual flavanol consumption
Proceedings of the National Academy of Sciences2023-05-3045 citations
Multivitamin Supplementation Improves Memory in Older Adults: A Randomized Clinical Trial.
2023-05-2421 citations
Design and baseline characteristics of participants in the COcoa Supplement and Multivitamin Outcomes Study (COSMOS).
2022-03-1223 citations
Effect of cocoa flavanol supplementation for the prevention of cardiovascular disease events: the COcoa Supplement and Multivitamin Outcomes Study (COSMOS) randomized clinical trial
American Journal of Clinical Nutrition2022-03-08153 citations
Multivitamins in the prevention of cancer and cardiovascular disease: the COcoa Supplement and Multivitamin Outcomes Study (COSMOS) randomized clinical trial
American Journal of Clinical Nutrition2022-03-0841 citations