FindTrial
Sign In

Cocoa extract

DIETARY_SUPPLEMENT7 trials

Sponsors

Clinica Universidad de Navarra, Universidad de Navarra, Brigham and Women's Hospital, Columbia University, Augusta University

Conditions

Age Related Macular DegenerationAgingCancerCardiovascular DiseaseCardiovascular DiseasesCardiovascular Risk FactorsCataractCognitive Change

Phase 4

COcoa Supplement and Multivitamin Outcomes Study
CompletedNCT02422745
Brigham and Women's HospitalCancer, Cardiovascular Disease
Start: 2015-06-01End: 2023-06-05Updated: 2026-07-13
Cataract and AMD in a Trial of a Multivitamin and Cocoa Extract
NCT03205202
Brigham and Women's HospitalAge Related Macular Degeneration, Cataract
Start: 2015-06-01End: 2022-10-31Target: 21442Updated: 2021-09-17
Cocoa Supplementation, Inflammaging, and Epigenetic Aging
NCT05510375
Augusta UniversityAging, Cardiovascular Diseases, Inflammation
Start: 2015-06-30End: 2023-09-30Updated: 2022-08-22

Unknown Phase

Cocoa Extract-enriched Meals and Cardiovascular Risk in Older Population
CompletedNCT01596309
Clinica Universidad de Navarra, Universidad de NavarraCardiovascular Risk Factors
Start: 2012-01-31End: 2012-12-31Updated: 2013-06-18
Investigating the Effects of Cocoa Flavanol on Cognition Assessed Online
CompletedNCT04582617
Columbia UniversityAging, Cognitive Change
Start: 2016-08-26End: 2020-12-31Updated: 2023-04-07
COcoa Supplement and Multivitamin Outcomes Study: Effects on Falls and Physical Performance
Active, not recruitingNCT05232669
Brigham and Women's HospitalFall, Fracture, Physical Performance
Start: 2021-05-15End: 2027-02-01Updated: 2026-04-13
Cocoa Extract for Migraine Trial
RecruitingNCT06808230
Brigham and Women's HospitalMigraine
Start: 2025-06-23End: 2026-12-01Target: 114Updated: 2026-06-29

Related Papers

Effects of daily multivitamin-multimineral supplementation on metabolomic profiles: 2-year findings from the COSMOS randomized clinical trial.
2026-03-30
Long-term effect of multivitamin supplementation on incident self-reported hypertension and blood pressure changes in the COSMOS trial.
2025-11-20
The overlooked impact of background diet and adherence in nutrition trials.
2025-07-14
Cocoa Flavanol Supplementation and Risk of Age-Related Macular Degeneration
JAMA Ophthalmology2025-03-27
Effects of cocoa extract supplementation and multivitamin/multimineral supplements on self-reported fractures in the Cocoa Supplement and Multivitamins Outcomes Study randomized clinical trial
Journal of Bone and Mineral Research2025-02-182 citations
Effect of multivitamin-mineral supplementation versus placebo on cognitive function: results from the clinic subcohort of the COcoa Supplement and Multivitamin Outcomes Study (COSMOS) randomized clinical trial and meta-analysis of 3 cognitive studies within COSMOS.
2024-01-1817 citations
Effect of cocoa extract supplementation on cognitive function: results from the clinic subcohort of the COSMOS trial.
2023-12-075 citations
Dietary flavanols restore hippocampal-dependent memory in older adults with lower diet quality and lower habitual flavanol consumption
Proceedings of the National Academy of Sciences2023-05-3045 citations
Multivitamin Supplementation Improves Memory in Older Adults: A Randomized Clinical Trial.
2023-05-2421 citations
Design and baseline characteristics of participants in the COcoa Supplement and Multivitamin Outcomes Study (COSMOS).
2022-03-1223 citations
Effect of cocoa flavanol supplementation for the prevention of cardiovascular disease events: the COcoa Supplement and Multivitamin Outcomes Study (COSMOS) randomized clinical trial
American Journal of Clinical Nutrition2022-03-08153 citations
Multivitamins in the prevention of cancer and cardiovascular disease: the COcoa Supplement and Multivitamin Outcomes Study (COSMOS) randomized clinical trial
American Journal of Clinical Nutrition2022-03-0841 citations
An Increase in Plasma Homovanillic Acid with Cocoa Extract Consumption Is Associated with the Alleviation of Depressive Symptoms in Overweight or Obese Adults on an Energy Restricted Diet in a Randomized Controlled Trial.
2015-04-0119 citations
Assessment of DNA damage using comet assay in middle-aged overweight/obese subjects after following a hypocaloric diet supplemented with cocoa extract
Mutagenesis2014-12-1922 citations
Increases in plasma 25(OH)D levels are related to improvements in body composition and blood pressure in middle-aged subjects after a weight loss intervention: Longitudinal study.
2014-11-1118 citations
Oxidised LDL levels decreases after the consumption of ready-to-eat meals supplemented with cocoa extract within a hypocaloric diet
Nutrition Metabolism and Cardiovascular Diseases2013-11-0162 citations