Coartem

DRUG14 trials

Sponsors

London School of Hygiene and Tropical Medicine, Dafra Pharma, Boston University, Sanofi, Albert Schweitzer Hospital

Conditions

Acute Uncomplicated Plasmodium Falciparum MalariaMalariaPlasmodium Falciparum MalariaPneumoniaSevere MalariaUncomplicated Plasmodium Falciparum Malaria

Phase 1

Safety, Immunogenicity, and Protective Efficacy of Radiation Attenuated Plasmodium Falciparum NF54 Sporozoites in Healthy African Adults in Mali

CompletedNCT02627456

National Institute of Allergy and Infectious Diseases (NIAID)Malaria

Start: 2015-12-09End: 2018-07-03Updated: 2021-04-21

Safety and Immunogenicity of Pfs25M-EPA/AS01 and Pfs230D1M-EPA/AS01 Vaccines, Transmission Blocking Vaccines Against Plasmodium Falciparum, at Full and Fractional Dosing in Adults in Mali

CompletedNCT02942277

National Institute of Allergy and Infectious Diseases (NIAID)Malaria

Start: 2016-10-21End: 2020-07-15Updated: 2024-12-10

Sanaria PfSPZ Challenge With Pyrimethamine or Chloroquine Chemoprophylaxis Vaccination (PfSPZ-CVac Approach): A Randomized Double Blind Placebo Controlled Phase I/II Trial to Determine Safety and Protective Efficacy Against Natural Plasmodium Falcipa...

CompletedNCT03952650

National Institute of Allergy and Infectious Diseases (NIAID)Malaria

Start: 2019-05-23End: 2021-02-10Updated: 2022-07-12

Phase 2

Efficacy and Safety of KAF156 in Combination With LUM-SDF in Adults and Children With Uncomplicated Plasmodium Falciparum Malaria

CompletedNCT03167242

Novartis PharmaceuticalsAcute Uncomplicated Plasmodium Falciparum Malaria

Start: 2017-08-02End: 2021-06-28Updated: 2022-02-10

Safety of KAE609 in Adults With Uncomplicated Plasmodium Falciparum Malaria.

CompletedNCT03334747

Novartis PharmaceuticalsMalaria

Start: 2017-11-16End: 2019-11-23Updated: 2021-10-11

Efficacy, Safety and Tolerability of KAF156 in Combination With Lumefantrine Solid Dispersion Formulation (LUM-SDF) in Pediatric Population With Uncomplicated Plasmodium Falciparum Malaria

CompletedNCT04546633

Novartis PharmaceuticalsUncomplicated Plasmodium Falciparum Malaria

Start: 2021-02-16End: 2024-08-28Updated: 2024-09-25

To Evaluate Efficacy, Safety, Tolerability and PK of Intravenous Cipargamin in Participants With Severe Plasmodium Falciparum Malaria

CompletedNCT04675931

Novartis PharmaceuticalsSevere Malaria

Start: 2022-03-07End: 2025-08-20Updated: 2025-12-22

Phase 3

Multi-Centre Trial Comparing Three Artemisinin-Based Combination Treatments on P. Falciparum Malaria

CompletedNCT00484900

Dafra PharmaPlasmodium Falciparum Malaria

Start: 2006-05-31End: 2007-05-31Updated: 2008-03-26

Efficacy, safety and tolerability of KLU156 in adults and children = 5 kg body weight with uncomplicated P. falciparum malaria

RecruitingPACTR202303470809477

Novartis Pharma AGMalaria

Start: 2023-07-31Target: 1500Updated: 2026-01-27

Efficacy, Safety and Tolerability of KLU156 in Adults and Children With Uncomplicated P. Falciparum Malaria

CompletedNCT05842954

Novartis PharmaceuticalsUncomplicated Plasmodium Falciparum Malaria

Start: 2024-03-07End: 2025-11-25Updated: 2026-01-27

Phase 4

Kintampo Trial of Combination Therapy for Malaria

CompletedNCT00119145

London School of Hygiene and Tropical MedicineMalaria

Start: 2005-06-30End: 2006-05-31Target: 510Updated: 2017-01-12

Cohort Study in Uganda Comparing Artesunate + Amiodaquine (Coarsucam) Versus Artemether + Lumenfantrine (Coartem) in the Treatment of Repeated Uncomplicated Plasmodium Falciparum Malaria Attacks

CompletedNCT00699920

Start: 2008-06-30End: 2010-06-30Updated: 2010-06-29

Unknown Phase

Zambia Integrated Management of Malaria and Pneumonia Study

CompletedNCT00513500

Boston UniversityMalaria, Pneumonia

Start: 2007-06-30End: 2009-09-30Updated: 2010-07-20

Relapses in Plasmodium Ovale and Efficacy of Artemether-lumefantrine for Mixed Species and Non-falciparum Malaria

CompletedNCT02528279

Albert Schweitzer HospitalMalaria

Start: 2014-10-31End: 2016-10-31Target: 50Updated: 2017-01-25

Related Papers

A Vaccine to Block <i>Plasmodium falciparum</i> Transmission

NEJM Evidence2025-06-245 citations

Pharmacokinetics of Ganaplacide and Lumefantrine in Adults, Adolescents, and Children with <i>Plasmodium falciparum</i> Malaria Treated with Ganaplacide Plus Lumefantrine Solid Dispersion Formulation: Analysis of Data from a Multinational Phase 2 Study

The Journal of Clinical Pharmacology2024-09-294 citations

Ganaplacide (KAF156) plus lumefantrine solid dispersion formulation combination for uncomplicated Plasmodium falciparum malaria: an open-label, multicentre, parallel-group, randomised, controlled, phase 2 trial.

2023-06-1328 citations

SEVUparin as a potential Adjunctive Treatment in children with severe malaria: A phase I trial safety and dose finding trial (SEVUSMAART).

2023-01-014 citations

Hepatic safety and tolerability of cipargamin (KAE609), in adult patients with Plasmodium falciparum malaria: a randomized, phase II, controlled, dose-escalation trial in sub-Saharan Africa.

2021-12-2018 citations

Safety and efficacy of a three-dose regimen of Plasmodium falciparum sporozoite vaccine in adults during an intense malaria transmission season in Mali: a randomised, controlled phase 1 trial.

2021-11-1868 citations

Efficacy of Cipargamin (KAE609) in a Randomized, Phase II Dose-Escalation Study in Adults in Sub-Saharan Africa With Uncomplicated <i>Plasmodium falciparum</i> Malaria

Clinical Infectious Diseases2021-08-1783 citations

Pfs230 yields higher malaria transmission–blocking vaccine activity than Pfs25 in humans but not mice

Journal of Clinical Investigation2021-02-09105 citations

Defining the Antimalarial Activity of Cipargamin in Healthy Volunteers Experimentally Infected with Blood-Stage Plasmodium falciparum.

2021-01-2020 citations

Prospective Clinical Trial Assessing Species-Specific Efficacy of Artemether-Lumefantrine for the Treatment of Plasmodium malariae, Plasmodium ovale, and Mixed Plasmodium Malaria in Gabon

Antimicrobial Agents and Chemotherapy2018-01-0833 citations

Controlled Human Malaria Infection in Semi-Immune Kenyan Adults (CHMI-SIKA): a study protocol to investigate <i>in vivo Plasmodium falciparum</i> malaria parasite growth in the context of pre-existing immunity.

2018-01-0134 citations

Efficacy and Safety of Fixed-Dose Artesunate-Amodiaquine vs. Artemether-Lumefantrine for Repeated Treatment of Uncomplicated Malaria in Ugandan Children

PLoS ONE2014-12-0135 citations

Community case management of fever due to malaria and pneumonia in children under five in Zambia: a cluster randomized controlled trial.

2010-09-21152 citations

Efficacy and safety of a fixed dose artesunate-sulphamethoxypyrazine-pyrimethamine compared to artemether-lumefantrine for the treatment of uncomplicated falciparum malaria across Africa: a randomized multi-centre trial.

2009-04-1443 citations

An open label, randomised trial of artesunate+amodiaquine, artesunate+chlorproguanil-dapsone and artemether-lumefantrine for the treatment of uncomplicated malaria.

2008-06-2539 citations