Closed Loop Stimulation (CLS)

DEVICE3 trials

Sponsors

GOTO TOSHIHIKO, Goto Toshihiko, Biotronik, Inc.

Conditions

Bradycardiasinus sinus syndrome sinus sinus syndrome

Phase 1

Safety and Appropriateness of Pacemakers with Closed Loop Stimulation in Patients with Sick Sinus Syndrome

RecruitingJPRN-jRCTs042250075

GOTO TOSHIHIKOsinus sinus syndrome sinus sinus syndrome

Start: 2025-11-18Target: 20Updated: 2026-06-29

Safety and Appropriateness of Pacemakers with Closed Loop Stimulation in Patients with Sick Sinus Syndrome - A Study in Patients with a History of Atrial Fibrillation

RecruitingJPRN-jRCTs042250162

Goto Toshihikosinus sinus syndrome sinus sinus syndrome

Start: 2026-01-27Target: 20Updated: 2026-06-29

Phase 4

Effectiveness of Pacemaker With Closed Loop Stimulation Compared to Pacemakers With and Without Standard Rate Response

CompletedNCT00355797

Biotronik, Inc.Bradycardia

Start: 2006-05-31End: 2010-12-31Updated: 2012-12-20

Related Papers

Effect of rate-adaptive pacing on performance and physiological parameters during activities of daily living in the elderly: results from the CLEAR (Cylos Responds with Physiologic Rate Changes during Daily Activities) study.

2013-02-1714 citations