Clinical Center Reference Endotoxin (CCRE)

BIOLOGICAL4 trials

Sponsors

University of North Carolina, Chapel Hill

Conditions

AsthmaHealthyHealthy ControlsHypersensitivityRhinitis, Allergic, PerennialRhinitis, Allergic, Seasonal

Phase 1

Effect of a 10,000 EU Dose of Endotoxin in Allergic and Mildly Asthmatic Adults

CompletedNCT00839189

University of North Carolina, Chapel HillAsthma, Rhinitis, Allergic, Perennial, Rhinitis, Allergic, Seasonal

Start: 2002-10-31End: 2006-06-30Updated: 2009-12-09

A Study of Inhalation of 20,000 EU CCRE in Normal Volunteers Compared to Allergic Asthmatic Individuals

CompletedNCT00839124

University of North Carolina, Chapel HillAsthma, Hypersensitivity

Start: 2009-01-31End: 2012-09-30Updated: 2012-12-05

Response of Airway Cells to 20,000 EU of Endotoxin in Normal Adults

TerminatedNCT00838851

University of North Carolina, Chapel HillHealthy Controls

Start: 2003-08-31End: 2012-07-31Updated: 2012-10-08

Effects of 20,000 EU of Clinical Center Reference Endotoxin (CCRE) Versus Placebo(ENDOHEART)

CompletedNCT03623022

University of North Carolina, Chapel HillHealthy

Start: 2018-10-17End: 2019-09-17Updated: 2019-09-20