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CISPLATIN-EBEWE

DRUG9 trials

Sponsors

Bristol-Myers Squibb International Corporation, Bristol Myers Squibb International Corporation, Bristol-Myers Squibb Services Unlimited Company, Revolution Medicines Inc., F. Hoffmann-La Roche AG

Conditions

Bladder Cancer Muscle-Invasive Bladder CancerEarly Stage Non-Small Cell Lung Cancer (NSCLC)Lung CancerPreviously Untreated Advanced or Metastatic Non-Squamous Non−Small Cell Lung CancerPreviously Untreated Locally Advanced Non-small Cell Lung Cancer (LA NSCLC)Resectable Stage II-IIIB Non-small cell lung cancerStage IV Non-Small Cell Lung Cancer (NSCLC)Untreated Unresectable or Metastatic Urothelial Cancer

Phase 1

Phase 3

A Phase 3, Randomized, Open Label Study to Compare Nivolumab plus Concurrent Chemoradiotherapy (CCRT) followed by Nivolumab plus Ipilimumab or Nivolumab plus CCRT Followed by Nivolumab vs CCRT followed by Durvalumab in Previously Untreated, Locally Advanced Nonsmall Cell Lung Cancer (LA NSCLC)
CompletedCTIS2022-502886-71-00
Bristol Myers Squibb International CorporationPreviously Untreated Locally Advanced Non-small Cell Lung Cancer (LA NSCLC)
Start: 2019-11-20End: 2024-05-31Target: 485Updated: 2024-05-20
Randomized, Open-Label, Phase 3 Trial of Nivolumab plus Ipilimumab or Nivolumab plus Platinum-Doublet Chemotherapy versus Platinum-Doublet Chemotherapy in Early Stage NSCLC
CompletedCTIS2022-501360-18-00
Bristol-Myers Squibb International CorporationEarly Stage Non-Small Cell Lung Cancer (NSCLC)
Start: 2017-03-15End: 2024-12-03Target: 194Updated: 2024-12-03
A Phase 3, Randomized, Double-blind Study of Neoadjuvant Chemotherapy plus Nivolumab versus Neoadjuvant Chemotherapy plus Placebo, followed by Surgical Resection and Adjuvant Treatment with Nivolumab or Placebo for Participants with Resectable Stage II-IIIB Non-small Cell Lung Cancer (CheckMate 77T, CHECKpoint pathway and nivoluMAb clinical Trial Evaluation 77T)
Active, not recruitingCTIS2022-502658-15-00
Bristol-Myers Squibb Services Unlimited CompanyResectable Stage II-IIIB Non-small cell lung cancer
Start: 2019-09-22Target: 252Updated: 2025-10-08
A Phase 3, Randomized Study of Nivolumab plus Ipilimumab in Combination with Chemotherapy vs Chemotherapy alone as First Line Therapy in Stage IV Non-Small Cell Lung Cancer (NSCLC)
CompletedCTIS2023-508757-75-00
Bristol Myers Squibb International CorporationStage IV Non-Small Cell Lung Cancer (NSCLC)
Start: 2017-09-18End: 2024-10-18Target: 456Updated: 2024-10-28
A Phase 3, Open-label, Randomized Study of Nivolumab Combined with Ipilimumab, or with Standard of Care Chemotherapy, versus Standard of Care Chemotherapy in Participants with Previously Untreated Unresectable or Metastatic Urothelial Cancer
Active, not recruitingCTIS2022-501784-40-00
Bristol Myers Squibb International CorporationUntreated Unresectable or Metastatic Urothelial Cancer
Start: 2017-05-26Target: 701Updated: 2026-01-26
A Phase 3, Randomized, Study of Neoadjuvant Chemotherapy alone versus Neoadjuvant Chemotherapy plus Nivolumab or Nivolumab and BMS- 986205, Followed by Continued Post- Surgery Therapy with Nivolumab or Nivolumab and BMS-986205 in Participants with Muscle-Invasive Bladder Cancer
Active, not recruitingCTIS2024-512158-12-00
Bristol-Myers Squibb Services Unlimited CompanyBladder Cancer Muscle-Invasive Bladder Cancer
Start: 2018-12-14Target: 386Updated: 2025-10-20
A PHASE III, RANDOMIZED, OPEN-LABEL STUDY EVALUATING THE EFFICACY AND SAFETY OF DIVARASIB AND PEMBROLIZUMAB VERSUS PEMBROLIZUMAB AND PEMETREXED AND CARBOPLATIN OR CISPLATIN IN PATIENTS WITH PREVIOUSLY UNTREATED, KRAS G12C-MUTATED, ADVANCED OR METASTATIC NON-SQUAMOUS NON-SMALL CELL LUNG CANCER
RecruitingCTIS2024-518365-10-00
F. Hoffmann-La Roche AGPreviously Untreated Advanced or Metastatic Non-Squamous Non−Small Cell Lung Cancer
Start: 2025-10-28Target: 282Updated: 2026-01-13