CISPLATIN-EBEWE
Sponsors
Bristol-Myers Squibb International Corporation, Bristol Myers Squibb International Corporation, Bristol-Myers Squibb Services Unlimited Company, Revolution Medicines Inc., F. Hoffmann-La Roche AG
Conditions
Bladder Cancer
Muscle-Invasive Bladder CancerEarly Stage Non-Small Cell Lung Cancer (NSCLC)Lung CancerPreviously Untreated Advanced or Metastatic Non-Squamous Non−Small Cell Lung CancerPreviously Untreated Locally Advanced Non-small Cell Lung Cancer (LA NSCLC)Resectable Stage II-IIIB Non-small cell lung cancerStage IV Non-Small Cell Lung Cancer (NSCLC)Untreated Unresectable or Metastatic Urothelial Cancer
Phase 1
Study of RMC-6291, With or Without RMC-6236, in Combination With Other Anti-Cancer Agents, in Patients With RAS G12C-Mutated Non-Small Cell Lung Cancer – Subprotocol A
RecruitingCTIS2023-509571-16-00
Start: 2024-07-17Target: 162Updated: 2025-12-17
A Phase 1b/2 Open-Label, Multicenter Study of RMC-6236 in Combination with Pembrolizumab with or without Chemotherapy, in Patients with RAS‑Mutated Non-Small Cell Lung Cancer (NSCLC) – Subprotocol B
RecruitingCTIS2023-509572-42-00
Start: 2024-07-17Target: 180Updated: 2026-01-13
Phase 3
A Phase 3, Randomized, Open Label Study to Compare Nivolumab plus Concurrent Chemoradiotherapy (CCRT) followed by Nivolumab plus Ipilimumab or Nivolumab plus CCRT Followed by Nivolumab vs CCRT followed by Durvalumab in Previously Untreated, Locally Advanced Nonsmall Cell Lung Cancer (LA NSCLC)
CompletedCTIS2022-502886-71-00
Start: 2019-11-20End: 2024-05-31Target: 485Updated: 2024-05-20
Randomized, Open-Label, Phase 3 Trial of Nivolumab plus Ipilimumab or Nivolumab plus Platinum-Doublet Chemotherapy versus Platinum-Doublet
Chemotherapy in Early Stage NSCLC
CompletedCTIS2022-501360-18-00
Start: 2017-03-15End: 2024-12-03Target: 194Updated: 2024-12-03
A Phase 3, Randomized, Double-blind Study of Neoadjuvant Chemotherapy plus Nivolumab versus Neoadjuvant Chemotherapy plus Placebo, followed by Surgical Resection and Adjuvant Treatment with Nivolumab or Placebo for Participants with Resectable Stage II-IIIB Non-small Cell Lung Cancer (CheckMate 77T, CHECKpoint pathway and nivoluMAb clinical Trial Evaluation 77T)
Active, not recruitingCTIS2022-502658-15-00
Start: 2019-09-22Target: 252Updated: 2025-10-08
A Phase 3, Randomized Study of Nivolumab plus Ipilimumab in Combination with Chemotherapy vs Chemotherapy alone as First Line Therapy in Stage IV Non-Small Cell Lung Cancer (NSCLC)
CompletedCTIS2023-508757-75-00
Start: 2017-09-18End: 2024-10-18Target: 456Updated: 2024-10-28
A Phase 3, Open-label, Randomized Study of Nivolumab Combined with Ipilimumab, or with Standard of Care Chemotherapy, versus Standard of Care Chemotherapy in Participants with Previously Untreated Unresectable or Metastatic Urothelial Cancer
Active, not recruitingCTIS2022-501784-40-00
Start: 2017-05-26Target: 701Updated: 2026-01-26
A Phase 3, Randomized, Study of Neoadjuvant Chemotherapy alone versus
Neoadjuvant Chemotherapy plus Nivolumab or Nivolumab and BMS-
986205, Followed by Continued Post- Surgery Therapy with Nivolumab or
Nivolumab and BMS-986205 in Participants with Muscle-Invasive Bladder
Cancer
Active, not recruitingCTIS2024-512158-12-00
Start: 2018-12-14Target: 386Updated: 2025-10-20
A PHASE III, RANDOMIZED, OPEN-LABEL STUDY EVALUATING THE EFFICACY AND SAFETY OF DIVARASIB AND PEMBROLIZUMAB VERSUS PEMBROLIZUMAB AND PEMETREXED AND CARBOPLATIN OR CISPLATIN IN PATIENTS WITH PREVIOUSLY UNTREATED, KRAS G12C-MUTATED, ADVANCED OR METASTATIC NON-SQUAMOUS NON-SMALL CELL LUNG CANCER
RecruitingCTIS2024-518365-10-00
Start: 2025-10-28Target: 282Updated: 2026-01-13