CIML NK cell infusion

BIOLOGICAL3 trials

Sponsors

Washington University School of Medicine, Dana-Farber Cancer Institute

Conditions

Acute Myeloid LeukemiaRecurrent Head and Neck Squamous Cell CarcinomaSquamous Cell Carcinoma of the Head and Neck

Phase 1

Cytokine Induced Memory-like NK Cell Adoptive Therapy for Relapsed AML After Allogeneic Hematopoietic Cell Transplant

CompletedNCT03068819

Washington University School of MedicineAcute Myeloid Leukemia

Start: 2017-10-23End: 2025-06-15Updated: 2026-04-24

CIML NK Cell in Head & Neck Cancer

CompletedNCT04290546

Dana-Farber Cancer InstituteRecurrent Head and Neck Squamous Cell Carcinoma, Squamous Cell Carcinoma of the Head and Neck

Start: 2020-07-20End: 2024-12-16Updated: 2026-07-30

Phase 2

Cytokine Induced Memory-like NK Cell Adoptive Therapy After Haploidentical Donor Hematopoietic Cell Transplantation

Active, not recruitingNCT02782546

Washington University School of MedicineAcute Myeloid Leukemia

Start: 2017-01-30End: 2028-02-13Updated: 2026-06-25

Related Papers

First-in-human evaluation of memory-like NK cells with an IL-15 super-agonist and CTLA-4 blockade in advanced head and neck cancer.

2025-02-1410 citations

CTLA-4 Blockade Results in the Enrichment of Proliferative CD56 dimCD16 + NK Cells Following Infusion of Haploidentical Donor Memory-like Natural Killer Cells Plus IL-15 Superagonist in a Phase 1 Trial

Blood2023-11-021 citations

Hematopoietic cell transplantation donor-derived memory-like NK cells functionally persist after transfer into patients with leukemia

Science Translational Medicine2022-02-23108 citations

Donor memory-like NK cells persist and induce remissions in pediatric patients with relapsed AML after transplant

Blood2021-12-06148 citations

Cytokine-Induced Memory-like NK Cells Have a Distinct Single Cell Transcriptional Profile and Persist for Months in Adult and Pediatric Leukemia Patients after Adoptive Transfer

Blood2021-11-053 citations

Cytokine-Induced Memory-like (ML) NK Cells Persist for > 2 Months Following Adoptive Transfer into Leukemia Patients with a MHC-Compatible Hematopoietic Cell Transplant (HCT)

Blood2019-11-1324 citations

Adoptively Transferred Donor-Derived Cytokine Induced Memory-like NK Cells Persist and Induce Remission in Pediatric Patient with Relapsed Acute Myeloid Leukemia after Hematopoietic Cell Transplantation

Blood2019-11-1315 citations

Abstract 5704: Mass cytometry identifies the expansion, persistence, and immune checkpoints of adoptively transferred memory-like NK cells in patients with leukemia

Cancer Research2018-07-013 citations