Cholic Acid

DRUG7 trials

Sponsors

Amsterdam UMC Stichting, University of Cincinnati, University of Texas Southwestern Medical Center, Mirum Pharmaceuticals, Inc., University of Nebraska

Conditions

AdrenoleukodystrophyBifunctional Enzyme DeficiencyBile Acid Synthesis DefectBile acid synthesis defectsBile acid synthesis defects (BASD), 3ß-hydroxy-?5-C27-steroid oxidoreductase, ?4-3-oxosteroid-5ß-reductase, cholesterol 7a-hydroxylase (CYP7A1), and a-methylacyl-CoA racemase (AMACR), Zellweger spectrum disorderHepatic SteatosisInborn Errors of Bile Acid SynthesisInfantile Refsum's Disease

Phase 1

Smith-Lemli-Opitz Syndrome and Cholic Acid

CompletedNCT03720990

University of NebraskaSmith-Lemli-Opitz Syndrome

Start: 2021-03-27End: 2023-09-30Updated: 2024-04-30

Phase 2

Cholic Acid for Hepatic Steatosis in Lipodystrophy

CompletedNCT00457639

University of Texas Southwestern Medical CenterHepatic Steatosis

Start: 2006-04-30End: 2011-04-30Updated: 2025-08-06

Phase 3

Efficacy of To Be Marketed (TBM) Cholic Acid Capsules Used to Treat Children With Inborn Errors of Bile Acid Synthesis

CompletedNCT01115582

Mirum Pharmaceuticals, Inc.Inborn Errors of Bile Acid Synthesis

Start: 2010-04-30End: 2010-08-31Updated: 2023-10-03

Open Label, Continuation Study of Cholic Acid in Subjects With Inborn Errors of Bile Acid Synthesis

CompletedNCT01438411

Mirum Pharmaceuticals, Inc.Bile Acid Synthesis Defect

Start: 2010-01-31End: 2016-07-31Updated: 2023-10-03

Long-term safety study of personalized cholic acid treatment in patients with bile acid synthesis defects

CompletedCTIS2024-518652-23-00

Amsterdam UMC StichtingBile acid synthesis defects

End: 2025-03-17Target: 8Updated: 2024-11-25

Unknown Phase

Study of Bile Acids in Patients With Peroxisomal Disorders

TerminatedNCT00004442

University of CincinnatiAdrenoleukodystrophy, Bifunctional Enzyme Deficiency, Infantile Refsum's Disease +1

End: 1999-04-30Target: 25Updated: 2015-03-25

Long-term safety study of personalized cholic acid treatment in patients with bile acid synthesis defects

RecruitingNL-OMON25657

Amsterdam UMCBile acid synthesis defects (BASD), 3ß-hydroxy-?5-C27-steroid oxidoreductase, ?4-3-oxosteroid-5ß-reductase, cholesterol 7a-hydroxylase (CYP7A1), and a-methylacyl-CoA racemase (AMACR), Zellweger spectrum disorder

Start: 2020-05-18Target: 40Updated: 2024-02-28