Chloroquine (CQ)

DRUG6 trials

Sponsors

Institute of Tropical Medicine, Belgium, London School of Hygiene and Tropical Medicine, Pfizer, National Institute of Allergy and Infectious Diseases (NIAID), U.S. Army Medical Research and Development Command

Conditions

MalariaMalaria ProphylaxisMalaria in PregnancyUncomplicated Falciparum MalariaUncomplicated P. Vivax Mono-infection

Phase 1

A Phase 1 Study To Estimate The Relative Bioavailability Of Co-Administered Formulations Of Azithromycin Microsphere And Chloroquine Test Formulation Compared With Co-Administered Immediate Release Individual Azithromycin And Chloroquine Tablets In Healthy Adult Subjects

CompletedNCT01100060

PfizerMalaria Prophylaxis

Start: 2010-04-30End: 2010-06-30Updated: 2010-08-25

Sanaria PfSPZ Challenge With Pyrimethamine Chemoprophylaxis (PfSPZ-CVac Approach): Phase 1 Trial to Determine Safety and Protective Efficacy of Sanaria PfSPZ Challenge With Concurrent Pyrimethamine Treatment That Inhibits Development of Asexual B...

CompletedNCT02511054

National Institute of Allergy and Infectious Diseases (NIAID)Malaria

Start: 2015-07-21End: 2017-06-01Updated: 2017-07-02

Phase 2

Trial of Artesunate Combination Therapy in Pakistan

CompletedNCT00959517

London School of Hygiene and Tropical MedicineUncomplicated Falciparum Malaria

Start: 2001-07-31End: 2006-08-31Updated: 2009-08-14

Chloroquine (CQ) and Azithromycin (AZ) Combination for Malaria Prophylaxis

WithdrawnNCT03278808

U.S. Army Medical Research and Development CommandMalaria

Start: 2018-09-17End: 2020-01-01Updated: 2020-02-27

Phase 4

Prevention of Intrauterine Growth Retardation in Burkina Faso: the Malaria Component

CompletedNCT00680732

Institute of Tropical Medicine, BelgiumMalaria, Malaria in Pregnancy

Start: 2003-06-30End: 2006-10-31Updated: 2010-09-14

Unknown Phase

Tafenoquine Combinations for Improved Radical Cure Efficacy of Plasmodium Vivax

Not yet recruitingNCT07533136

Walter Reed Army Institute of Research (WRAIR)Uncomplicated P. Vivax Mono-infection

Start: 2026-05-01End: 2029-05-30Target: 300Updated: 2026-04-16

Related Papers

Two chemoattenuated PfSPZ malaria vaccines induce sterile hepatic immunity.

2021-06-3091 citations

An open label study of the safety and efficacy of a single dose of weekly chloroquine and azithromycin administered for malaria prophylaxis in healthy adults challenged with 7G8 chloroquine-resistant Plasmodium falciparum in a controlled human malaria infection model.

2020-09-161 citations

Defining Plasmodium falciparum treatment in South West Asia: a randomized trial comparing artesunate or primaquine combined with chloroquine or SP.

2012-01-3114 citations