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chimeric antigen receptor T cell treatment
BIOLOGICAL
2 trials
Sponsors
Beijing Boren Hospital
Conditions
Refractory T Lymphoblastic Leukemia/Lymphoma
Relapse/Recurrence
T Cell Lymphoma
T-cell Leukemia
T-cell Leukemia/Lymphoma
Phase 1
Phase I Clinical Trial of Autologous CD7-CAR T Cell Therapy for High-risk Acute T-cell Leukemia/lymphoma
Completed
NCT04840875
Beijing Boren Hospital
T-cell Leukemia, T Cell Lymphoma
Start: 2021-09-14
End: 2023-09-01
Updated: 2024-11-14
Phase 2
Multi-centers, Open-Label, Phase 2 Study to Evaluate the Efficacy and Safety of Donor-Derived CD7 CAR T Cells in Subjects With Relapsed or Refractory T-cell Leukemia/Lymphoma
Completed
NCT04689659
Beijing Boren Hospital
Refractory T Lymphoblastic Leukemia/Lymphoma, Relapse/Recurrence, T-cell Leukemia/Lymphoma
Start: 2021-12-01
End: 2024-04-03
Updated: 2025-05-18
Related Papers
Donor-derived CD7 CAR T cells for pediatric and adult relapsed/refractory T-ALL/LBL: a phase 2 trial.
2025-12-01
1 citations
Potential benefits of using a different donor for transplantation consolidation after donor-derived CD7 CAR T.
Journal of Clinical Oncology
2025-05-28
CD7 CAR T-Cell Therapy in Relapsed or Refractory T-Cell Acute Lymphoblastic Leukemia: A Retrospective Study
Blood
2024-11-05
2 citations
Autologous CD7 CAR-T cells generated without T cell pre-selection in pediatric patients with relapsed/refractory T-ALL: A phase I trial.
2024-09-07
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CAR T-Cell Therapy in Relapsed or Refractory T-Cell Acute Lymphoblastic Leukemia/Lymphoma: A Retrospective Study
Blood
2023-11-02
2 citations
Efficacy and Safety of Donor-Derived CD7 CAR T Cells for r/r T-Cell Acute Lymphoblastic Leukemia/Lymphoma: Interim Analysis from a Phase 2 Trial
Blood
2022-11-15
7 citations
Autologous CD7-targeted CAR T-cell therapy for refractory or relapsed T-cell acute lymphoblastic leukemia/lymphoma.
Journal of Clinical Oncology
2022-06-01
13 citations
Donor-Derived CD7 Chimeric Antigen Receptor T Cells for T-Cell Acute Lymphoblastic Leukemia: First-in-Human, Phase I Trial
Journal of Clinical Oncology
2021-07-29
279 citations