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Chenodeoxycholic Acid

DRUG12 trials

Sponsors

National Center for Research Resources (NCRR), University of Cincinnati, US Department of Veterans Affairs, University Hospital, Basel, Switzerland, University Hospital, Gentofte, Copenhagen

Conditions

AdrenoleukodystrophyBifunctional Enzyme DeficiencyBile Acid MalabsorptionCerebrotendinous XanthomatosesCerebrotendinous XanthomatosisCholelithiasisFamilial Combined HyperlipidemiaFamilial Hypertriglyceridemia

Early Phase 1

Effects of FXR Activation on Hepatic Lipid and Glucose Metabolism
CompletedNCT00465751
University Hospital, Basel, SwitzerlandFamilial Combined Hyperlipidemia, Familial Hypertriglyceridemia, Metabolic Syndrome
Start: 2004-10-31Updated: 2012-03-09

Phase 1

Bioequivalence Study to Compare Chenodeoxycholic Acid Capsules (250mg Chenodeoxycholic Acid) Versus Chenodeoxycholic Acid Leadiant 250 mg Hard Capsules (250mg Chenodeoxycholic Acid)
CompletedNCT06180057
Humanis Saglık Anonim SirketiCerebrotendinous Xanthomatoses
Start: 2022-06-12End: 2022-08-15Updated: 2023-12-28

Phase 2

Phase II Study of Cholesterol- and Cholestanol-Free Diet, Lovastatin, and Chenodeoxycholic Acid for Cerebrotendinous Xanthomatosis
NCT00004346
National Center for Research Resources (NCRR)Cerebrotendinous Xanthomatosis
Start: 1996-01-31Target: 5Updated: 2005-06-24

Phase 3

A Study of Chenodeoxycholic Acid (CDCA) in Newly Diagnosed Participants With Cerebrotendinous Xanthomatosis (CTX)
WithdrawnNCT06260748
Leadiant Biosciences, Inc.Cerebrotendinous Xanthomatoses
Start: 2024-05-27End: 2025-12-31Updated: 2024-11-18

Phase 4

Effects of Bile Acids on GLP-1 Secretion After Roux-en-Y Gastric Bypass
CompletedNCT02340247
Hvidovre University HospitalSevere Obesity
Start: 2014-11-30Updated: 2016-06-30
Effects of Bile Acids and Bile Acid Sequestrants on GLP-1 Secretion After Roux-en-Y Gastric Bypass
CompletedNCT02876484
Hvidovre University HospitalSevere Obesity
Start: 2016-06-30End: 2020-11-30Updated: 2020-11-30
Effect of Bile Acids and Bile Acid Sequstrants on GLP-1 Secretion After Roux-en-Y Gastric Bypass
CompletedNCT02952963
Hvidovre University HospitalSevere Obesity
Start: 2016-10-31End: 2020-11-30Updated: 2020-11-30
Changes in Bile Acid Homeostasis and Stool Habits After Cholecystectomy
CompletedNCT03168555
Zealand University HospitalBile Acid Malabsorption, Cholelithiasis
Start: 2017-06-22End: 2019-05-15Updated: 2022-05-19

Unknown Phase

Study of Bile Acids in Patients With Peroxisomal Disorders
TerminatedNCT00004442
University of CincinnatiAdrenoleukodystrophy, Bifunctional Enzyme Deficiency, Infantile Refsum's Disease +1
End: 1999-04-30Target: 25Updated: 2015-03-25
Cholestanol in Humans
WithdrawnNCT00018694
US Department of Veterans AffairsCerebrotendinous Xanthomatosis
Start: 1999-10-31End: 2009-12-31Updated: 2013-10-14
Effect of Bile Acids on GLP-1 Secretion
CompletedNCT01666223
University Hospital, Gentofte, CopenhagenObesity, Type 2 Diabetes
Start: 2012-11-30End: 2013-06-30Updated: 2013-12-24
Safety and Efficacy of CDCA in CTX Chenodeoxycholic Acid (CDCA) in Patients Affected by Cerebrotendinous Xanthomatosis (CTX)
CompletedNCT05499026
Leadiant Biosciences Ltd.Cerebrotendinous Xanthomatoses
Start: 2014-12-09End: 2015-06-03Updated: 2022-08-12

Related Papers

Effect of cholecystectomy on bile acid diarrhoea biomarkers: A prospective clinical study
GastroHep2021-08-164 citations