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Ceftaroline fosamil

DRUG13 trials

Sponsors

Assistance Publique Hopitaux De Paris, Forest Laboratories, Pfizer, Baylor College of Medicine, Centre Hospitalier Universitaire Dijon

Conditions

Bone InfectionCatheter related bloodstream infections due to Staphylococcus aureusCommunity Acquired PneumoniaCommunity-Acquired Bacterial Pneumonia (CABP)Complicated Skin and Soft Tissue InfectionHematogenously Acquired Staphylococcus Aureus OsteomyelitisInfectionsInfections, Pediatrics

Phase 1

Ceftaroline for Treatment of Hematogenously Acquired Staphylococcus Aureus Osteomyelitis in Children
CompletedNCT02335905
Baylor College of MedicineBone Infection, Hematogenously Acquired Staphylococcus Aureus Osteomyelitis, Osteomyelitis
Start: 2015-06-03End: 2020-06-16Updated: 2021-11-02
Penetration of Ceftaroline Into Cerebrospinal Fluid(CSF)
CompletedNCT02806882
Centre Hospitalier Universitaire DijonMeningitis, Ventriculitis
Start: 2015-04-29End: 2016-10-24Updated: 2024-02-21

Phase 2

Safety and Efficacy Study of Ceftaroline Versus a Comparator in Pediatric Subjects With Complicated Skin Infections
CompletedNCT01400867
Forest LaboratoriesInfections, Pediatrics
Start: 2011-12-31End: 2014-07-31Updated: 2015-01-13
Safety and Efficacy Study of Ceftaroline Versus a Comparator in Pediatric Subjects With Community Acquired Bacterial Pneumonia (CABP)
CompletedNCT01530763
Forest LaboratoriesCommunity Acquired Pneumonia, Infections
Start: 2012-09-30End: 2014-07-31Updated: 2015-01-13
Safety, Tolerability and Efficacy of Ceftaroline in Paediatrics With Late-Onset Sepsis
TerminatedNCT02424734
PfizerLate-onset Sepsis
Start: 2015-08-04End: 2017-12-26Updated: 2018-09-13

Phase 3

Evaluation of Ceftaroline Fosamil Versus Vancomycin Plus Aztreonam in the Treatment of Patients With Skin Infections
CompletedNCT01499277
PfizerComplicated Skin and Soft Tissue Infection
Start: 2012-05-31End: 2015-01-31Updated: 2017-09-06
Evaluation of Ceftaroline Fosamil vs Vancomycin Plus Aztreonam in the Treatment of Patients With Skin Infections.
TerminatedNCT02202135
PfizerComplicated Skin and Soft Tissue Infection
Start: 2014-06-30End: 2015-01-31Updated: 2017-09-06
Randomized open-label controlled trial evaluating a single-dose intravenous Dalbavancin versus standard antibiotic therapy during catheterrelated bloodstream infections due to Staphylococcus aureus [DALICATH]
RecruitingCTIS2024-514952-34-00
Assistance Publique Hopitaux De ParisCatheter related bloodstream infections due to Staphylococcus aureus
Start: 2023-06-23Target: 406Updated: 2025-04-23

Phase 4

Study of Blood Levels of Ceftaroline Fosamil in Children Who Are Receiving Antibiotic Therapy in the Hospital
CompletedNCT01298843
Forest LaboratoriesInfections
Start: 2011-04-30End: 2013-02-28Updated: 2014-05-14
Evaluation of Ceftaroline Fosamil Versus a Comparator in Adult Subjects With Community-acquired Bacterial Pneumonia (CABP) With Risk for Methicillin-resistant Staphylococcus Aureus
CompletedNCT01645735
Forest LaboratoriesInfections
Start: 2012-10-31End: 2013-12-31Updated: 2016-02-01
Safety and Efficacy Study of Ceftaroline in Elderly Subjects With Community-Acquired Bacterial Pneumonia
WithdrawnNCT01666743
Forest LaboratoriesCommunity-Acquired Bacterial Pneumonia (CABP)
Start: 2012-11-30End: 2014-03-31Updated: 2013-02-11
Safety and Efficacy Study of Ceftaroline Versus a Comparator in Pediatric Subjects With Complicated Community Acquired Pneumonia (CABP)
CompletedNCT01669980
Forest LaboratoriesInfections, Pneumonia
Start: 2012-10-31End: 2014-08-31Updated: 2015-11-02
Safety and Efficacy Study of Ceftaroline in Subjects With Staphylococcus Aureus Bacteremia or With Persistent Methicillin-Resistant Staphylococcus Aureus Bacteremia
CompletedNCT01701219
Forest LaboratoriesMethicillin-resistant Staphylococcus Aureus (MRSA) Bacteremia, Staphylococcus Aureus Bacteremia
Start: 2013-01-31End: 2014-07-31Updated: 2014-07-31

Related Papers

Treatment outcomes of secondary bacteraemia in patients treated with ceftaroline fosamil: pooled results from six phase III clinical trials.
2021-12-162 citations
Impact of Underlying Comorbidities on Outcomes of Patients Treated with Ceftaroline Fosamil for Complicated Skin and Soft Tissue Infections: Pooled Results from Three Phase III Randomized Clinical Trials.
2021-11-063 citations
Baseline Characteristics and Outcomes Among Patients with Complicated Skin and Soft Tissue Infections Admitted to the Intensive Care Unit: Analysis of the Phase 3 COVERS Randomized Trial of Ceftaroline Fosamil Versus Vancomycin Plus Aztreonam.
2020-06-302 citations
Phase 2 Study of the Safety, Pharmacokinetics and Efficacy of Ceftaroline Fosamil in Neonates and Very Young Infants With Late-onset Sepsis
The Pediatric Infectious Disease Journal2020-02-2126 citations
Summary of the safety and tolerability of two treatment regimens of ceftaroline fosamil: 600 mg every 8 h versus 600 mg every 12 h.
2019-04-0111 citations
Ceftaroline fosamil therapy in patients with acute bacterial skin and skin-structure infections with systemic inflammatory signs: A retrospective dose comparison across three pivotal trials
International Journal of Antimicrobial Agents2019-02-016 citations
A Phase III, randomized, controlled, non-inferiority trial of ceftaroline fosamil 600 mg every 8 h versus vancomycin plus aztreonam in patients with complicated skin and soft tissue infection with systemic inflammatory response or underlying comorbidities.
2016-09-0148 citations
A Multicenter, Randomized, Observer-blinded, Active-controlled Study to Evaluate the Safety and Efficacy of Ceftaroline Versus Comparator in Pediatric Patients With Acute Bacterial Skin and Skin Structure Infection.
2016-08-0134 citations
A Randomized, Prospective Study of Pediatric Patients With Community-acquired Pneumonia Treated With Ceftaroline Versus Ceftriaxone.
2016-07-0134 citations
A Multicenter, Randomized, Observer-blinded, Active-controlled Study Evaluating the Safety and Effectiveness of Ceftaroline Compared With Ceftriaxone Plus Vancomycin in Pediatric Patients With Complicated Community-acquired Bacterial Pneumonia.
2016-07-0132 citations