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CD45RA-depleted DLI

BIOLOGICAL2 trials

Sponsors

St. Jude Children's Research Hospital

Conditions

Acute Lymphoblastic Leukemia (ALL)Acute Myeloid Leukemia (AML)Aplastic AnemiaBone Marrow Failure SyndromeChronic Myeloid Leukemia (CML)Hodgkin LymphomaJuvenile Myelomonocytic Leukemia (JMML)Myelodysplastic Syndromes (MDS)

Phase 2

TCRαβ-depleted Progenitor Cell Graft With Additional Memory T-cell DLI, Plus Selected Use of Blinatumomab, in Naive T-cell Depleted Haploidentical Donor Hematopoietc Cell Transplantation for Hematologic Malignancies
Active, not recruitingNCT03849651
St. Jude Children's Research HospitalAcute Lymphoblastic Leukemia (ALL), Acute Myeloid Leukemia (AML), Chronic Myeloid Leukemia (CML) +5
Start: 2019-01-31End: 2026-06-07Updated: 2026-03-04
Haploidentical HCT for Severe Aplastic Anemia
RecruitingNCT04558736
St. Jude Children's Research HospitalAplastic Anemia, Bone Marrow Failure Syndrome
Start: 2021-01-21End: 2030-07-01Target: 21Updated: 2025-07-04

Related Papers

Immune reconstitution following memory T-cell add back and prophylactic blinatumomab post TCRαβ/CD19-depleted haploidentical transplantation in pediatric patients with high-risk acute leukemia
Blood2025-11-03
Memory T-Cell Add Back and <i>Prophylactic</i> blinatumomab Post Tcrαβ Depleted Haploidentical Transplantation Results in Promising Outcomes in Pediatric Patients with High-Risk Acute Leukemia
Blood2024-11-05
CD45RO+ T-Cell Add Back and Prophylactic Blinatumomab Administration Post Tcrαβ/CD19-Depleted Haploidentical Transplantation in Pediatric Patients with High Risk Acute Leukemia
Blood2021-11-053 citations