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CD45RA-depleted DLI

BIOLOGICAL3 trials

Sponsors

St. Jude Children's Research Hospital, Ruijin Hospital

Conditions

Acute Lymphoblastic Leukemia (ALL)Acute Myeloid Leukemia (AML)Aplastic AnemiaBone Marrow Failure SyndromeChronic Myeloid Leukemia (CML)Haplo-identical HCTHematologic MalignancyHodgkin Lymphoma

Phase 1

CD45RA-depleted DLI for the Prevention of Viral Infections in High-risk Patients After Haploidentical Transplantation
Not yet recruitingNCT07672964
Ruijin HospitalHaplo-identical HCT, Hematologic Malignancy
Start: 2026-07-01End: 2028-07-31Target: 30Updated: 2026-06-29

Phase 2

TCRαβ-depleted Progenitor Cell Graft With Additional Memory T-cell DLI, Plus Selected Use of Blinatumomab, in Naive T-cell Depleted Haploidentical Donor Hematopoietc Cell Transplantation for Hematologic Malignancies
Active, not recruitingNCT03849651
St. Jude Children's Research HospitalAcute Lymphoblastic Leukemia (ALL), Acute Myeloid Leukemia (AML), Chronic Myeloid Leukemia (CML) +5
Start: 2019-01-31End: 2026-06-07Updated: 2026-06-03
Haploidentical HCT for Severe Aplastic Anemia
RecruitingNCT04558736
St. Jude Children's Research HospitalAplastic Anemia, Bone Marrow Failure Syndrome
Start: 2021-01-21End: 2030-07-01Target: 21Updated: 2025-07-04

Related Papers

Immune reconstitution following memory T-cell add back and prophylactic blinatumomab post TCRαβ/CD19-depleted haploidentical transplantation in pediatric patients with high-risk acute leukemia
Blood2025-11-03
Memory T-Cell Add Back and <i>Prophylactic</i> blinatumomab Post Tcrαβ Depleted Haploidentical Transplantation Results in Promising Outcomes in Pediatric Patients with High-Risk Acute Leukemia
Blood2024-11-05
CD45RO+ T-Cell Add Back and Prophylactic Blinatumomab Administration Post Tcrαβ/CD19-Depleted Haploidentical Transplantation in Pediatric Patients with High Risk Acute Leukemia
Blood2021-11-053 citations