CCNU

DRUG4 trials

Sponsors

Radiation Therapy Oncology Group, Alliance for Clinical Trials in Oncology, Massachusetts General Hospital, Advenchen Pharmaceuticals, LLC.

Conditions

Brain and Central Nervous System TumorsEndometrial NeoplasmsGlioblastomaOvarian NeoplasmsRecurrent GlioblastomaSoft Tissue Sarcoma (STS)

Phase 1

A Study of Catequentinib Hydrochloride (AL3818) in Endometrial, LGSOC, STS or GBM Cancers

Not yet recruitingNCT07811297

Advenchen Pharmaceuticals, LLC.Endometrial Neoplasms, Ovarian Neoplasms, Soft Tissue Sarcoma (STS) +1

Start: 2026-09-01End: 2031-09-01Target: 138Updated: 2026-09-10

Phase 3

Radiation Therapy Combined With Chemotherapy in Treating Patients With Anaplastic Astrocytoma or Mixed Gliomas

CompletedNCT00004259

Radiation Therapy Oncology GroupBrain and Central Nervous System Tumors

Start: 2000-06-30End: 2018-05-14Updated: 2019-09-12

Radiation Therapy With Concomitant and Adjuvant Temozolomide Versus Radiation Therapy With Adjuvant PCV Chemotherapy in Patients With Anaplastic Glioma or Low Grade Glioma

Active, not recruitingNCT00887146

Alliance for Clinical Trials in OncologyBrain and Central Nervous System Tumors

Start: 2009-09-01End: 2029-10-31Updated: 2026-01-22

Unknown Phase

FMISO PET Study of Glioblastoma

CompletedNCT02076152

Massachusetts General HospitalRecurrent Glioblastoma

Start: 2014-02-28End: 2019-04-30Updated: 2021-07-30

Related Papers

Improvement of functional outcome for patients with newly diagnosed grade 2 or 3 gliomas with co-deletion of 1p/19q – IMPROVE CODEL: the NOA-18 trial

BMC Cancer2022-06-1316 citations

CTNI-29. CODEL: PHASE III TRIAL OF RT ALONE, RT PLUS TMZ, OR TMZ ALONE FOR NEWLY-DIAGNOSED, 1p/19q CODELETED ANAPLASTIC OLIGODENDROGLIOMA. ANALYSIS FROM THE INITIAL STUDY DESIGN. (NCCTG N0577, ALLIANCE)

Neuro-Oncology2020-11-015 citations

Examiner accuracy in cognitive testing in multisite brain-tumor clinical trials: an analysis from the Alliance for Clinical Trials in Oncology

Neuro-Oncology Practice2018-11-244 citations

Chemotherapy of Oligodendrogliomas

Progress in neurological surgery2018-01-013 citations

Comprehensive mutation analysis in NRG Oncology/RTOG 9813: A phase III trial of RT + TMZ vs RT + nu for anaplastic astrocytoma and mixed anaplastic oligoastrocytoma (Astrocytoma Dominant).

Journal of Clinical Oncology2016-05-2023 citations

Results of NRG oncology/RTOG 9813: A phase III randomized study of radiation therapy (RT) and temozolomide (TMZ) versus RT and nitrosourea (NU) therapy for anaplastic astrocytoma (AA).

Journal of Clinical Oncology2015-05-2010 citations