CC-92480
Sponsors
Celgene Corp., Celgene, Bristol-Myers Squibb
Conditions
Healthy VolunteerHealthy VolunteersMultiple MyelomaRelapsed and refractory multiple myeloma (RRMM)Relapsed or Refractory Multiple Myeloma (RRMM)Relapsed or refractory multiple myeloma (RRMM) and newly diagnosed MM (NDMM)
Phase 1
A Safety, PK and Efficacy Study of CC-92480 Monotherapy and in Combination With Dexamethasone in Subjects With Relapsed and Refractory Multiple Myeloma (RRMM)
TerminatedNCT03374085
Start: 2018-02-06End: 2025-10-23Updated: 2026-02-09
Safety, Tolerability, Pharmacokinetics, Pharmacodynamics, and Food Effect of Single Ascending Doses of CC-92480 in Healthy Subjects
CompletedNCT03803644
Start: 2018-12-21End: 2019-05-28Updated: 2020-05-07
A Study to Determine the Recommended Dose and Regimen and to Evaluate the Safety and Preliminary Efficacy of CC-92480 in Combination With Standard Treatments in Participants With Relapsed or Refractory Multiple Myeloma (RRMM) and Newly Diagnosed Multiple Myeloma (NDMM)
Active, not recruitingNCT03989414
Start: 2019-09-30End: 2026-11-30Target: 424Updated: 2024-11-29
Relative Bioavailability and PPI Effects of CC-92480 Test and Reference Formulations in Healthy Subjects
CompletedNCT04211545
Start: 2019-10-21End: 2019-12-26Updated: 2020-05-08
A Study to Assess Safety, Tolerability, and Pharmacokinetics of CC-92480 Formulations in Healthy Adult Participants
CompletedNCT04839809
Start: 2021-01-19End: 2021-10-08Updated: 2021-12-10
A Study to Evaluate Safety, Drug Levels and Effectiveness of CC-92480 (BMS-986348) in Combination With Other Treatments in Participants With Relapsed or Refractory Multiple Myeloma
RecruitingNCT05372354
Start: 2022-10-18End: 2026-10-12Target: 260Updated: 2025-09-05
A Study to Assess the Drug Levels of CC-92480 After Coadministration With Rifampin and Itraconazole, and the Drug Levels of Digoxin and Rosuvastatin After Coadministration With CC-92480 in Healthy Participants
CompletedNCT05389722
Start: 2022-06-09End: 2022-11-12Updated: 2023-04-19
An Exploratory Phase 1b/2a Multicenter, Open-Label, Novel-Novel Combination Study to Assess the Safety, Pharmacokinetics, Pharmacodynamics, and Preliminary Efficacy of CC-92480 (BMS-986348) in Novel Therapeutic Combinations in Participants with Relapsed or Refractory Multiple Myeloma
RecruitingCTIS2023-509384-25-00
Start: 2022-12-30Target: 56Updated: 2025-10-10
A Phase 1/2, Multicenter, Open-label, Study to Determine the Recommended Dose and Regimen, and Evaluate the Safety and Preliminary Efficacy of CC-92480 in Combination with Standard Treatments in Subjects with Relapsed or Refractory Multiple Myeloma (RRMM) and Newly Diagnosed Multiple Myeloma (NDMM)
Active, not recruitingCTIS2023-505219-19-00
Start: 2019-09-03Target: 86Updated: 2025-09-03
A Phase 1b/2a, Multicenter, Open-label Study to Determine the Recommended Dose and Schedule, and Evaluate the Safety and Preliminary Efficacy of Mezigdomide in Combination with Elranatamab in Participants with Relapsed and/or Refractory Multiple Myeloma
RecruitingCTIS2025-522090-11-00
Start: 2026-01-22Target: 24Updated: 2025-11-21
Phase 2
Phase 3
A Phase 3, Two-stage, Randomized, Multicenter, Open-label Study Comparing Mezigdomide (CC-92480/BMS-986348), Carfilzomib, and Dexamethasone (MeziKd) Versus Carfilzomib and Dexamethasone (Kd) in Participants with Relapsed or Refractory Multiple Myeloma (RRMM): SUCCESSOR-2
Active, not recruitingCTIS2022-500861-29-00
Start: 2023-01-12Target: 238Updated: 2025-11-17
A Phase 3, Two-Stage, Randomized, Multicenter, Open-Label Study Comparing Mezigdomide (CC-92480), Bortezomib And Dexamethasone (MeziVd) Versus Pomalidomide, Bortezomib And Dexamethasone (PVd) In Subjects With Relapsed Or Refractory Multiple Myeloma (RRMM): Successor-1
RecruitingCTIS2023-509859-13-00
Start: 2022-11-09Target: 322Updated: 2025-09-25
Related Papers
3 more papers not shown