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CC-220

DRUG14 trials

Sponsors

Celgene, Celgene Corporation

Conditions

HealthyHealthy VolunteerHealthy VolunteersHepatic ImpairmentLupus Erythematosus, SystemicLymphomaLymphoma, B-CellLymphoma, Follicular

Phase 1

2-part Study to Assess Safety, Pharmacokinetics & Pharmacodynamics of CC-220 & Effect of Food on CC-220 in Healthy Subjects
CompletedNCT01733875
CelgeneHealthy
Start: 2012-11-01End: 2013-10-09Updated: 2019-11-12
3-part Study to Evaluate Safety, Tolerability, Pharmacokinetics & Pharmacodynamics of Multiple Doses of CC-220 and Relative Bioavailability of a Formulated CC-220 Capsule
CompletedNCT02034773
Celgene CorporationHealthy Volunteers
Start: 2013-05-31End: 2013-12-31Updated: 2014-01-13
A Study to Determine Dose, Safety, Tolerability and Efficacy of CC-220 Monotherapy, and in Combination With Other Treatments in Subjects With Multiple Myeloma
Active, not recruitingNCT02773030
CelgeneMultiple Myeloma
Start: 2016-10-14End: 2028-07-28Updated: 2026-03-20
Study to Evaluate the Effect of Cytochrome P450 (CYP) 3A Inhibition and Induction on the Pharmacokinetics of CC-220 in Healthy Subjects
CompletedNCT02820935
Celgene CorporationPharmacokinetics
Start: 2016-07-31End: 2016-09-30Updated: 2016-10-18
A Study to Assess the Relative Bioavailability of a New CC-220 Capsule Formulation, Compared to a Reference CC-220 Capsule Formulation, in Healthy Adult Subjects
CompletedNCT03135509
CelgeneHealthy Volunteers
Start: 2017-05-24End: 2017-06-28Updated: 2017-07-02
Radiolabeled Study of CC-220 in Healthy Male Subjects
CompletedNCT03294603
CelgeneHealthy Volunteer
Start: 2017-09-11End: 2017-10-16Updated: 2017-10-25
A Safety and Efficacy Trial of JCAR017 Combinations in Subjects With Relapsed/Refractory B-cell Malignancies
CompletedNCT03310619
CelgeneLymphoma, Follicular, Lymphoma, Large B-Cell, Diffuse, Lymphoma, Non-Hodgkin
Start: 2017-12-20End: 2023-02-15Updated: 2024-04-04
Evaluate the Pharmacokinetics of CC-220 in Subjects With Mild, Moderate, or Severe Hepatic Impairment Compared With Healthy Subjects
CompletedNCT03824678
CelgeneHealthy Volunteers, Hepatic Impairment
Start: 2019-02-13End: 2019-06-18Updated: 2020-07-27
A Dose Finding and Safety Study of CC-220, Alone and in Combination With an Anti-CD20 Monoclonal Antibody (mAb) in Subjects With Relapsed or Refractory Lymphomas
TerminatedNCT04464798
CelgeneLymphoma
Start: 2020-11-11End: 2025-01-09Updated: 2025-04-29
Safety and Efficacy of bb2121 (Ide-cel) Combinations in Multiple Myeloma
TerminatedNCT04855136
CelgeneMultiple Myeloma
Start: 2021-06-01End: 2025-04-25Updated: 2025-09-11
Study to Evaluate Tolerability of Iberdomide (CC-220) in Combination With Polatuzumab Vedotin Plus Rituximab or Tafasitamab or Rituximab Plus Chemotherapy in B-cell Lymphoma
WithdrawnNCT04882163
CelgeneLymphoma, B-Cell
Start: 2021-10-10End: 2029-04-07Updated: 2021-10-05
Study of Safety and Efficacy of Iberdomide (CC-220) and CC-99282 Combined With R-CHOP to Treat Lymphoma
RecruitingNCT04884035
CelgeneLymphoma, B-Cell
Start: 2021-09-15End: 2028-12-01Target: 224Updated: 2026-04-17

Phase 2

Related Papers

27 more papers not shown