CAZ-AVI

DRUG6 trials

Conditions

CAZ-AVICXLComplicated Intra-Abdominal InfectionEffect on Intestinal FloraFebrile NeutropeniaHealthyHealthy VolunteersNeoplasms

Phase 1

A Study to Assess the Levels of CAZ-AVI and Metronidazole in the Blood When Given Together and Separately

CompletedNCT01534247

PfizerHealthy

Start: 2012-02-29End: 2012-07-31Updated: 2017-09-05

A Study to Investigate the Effect of Administration of Ceftazidime-avibactam (CAZ-AVI) and Ceftaroline Fosamil -Avibactam (CXL) on the Intestinal Flora of Healthy Volunteers

CompletedNCT01789528

PfizerCAZ-AVI, CXL, Effect on Intestinal Flora +3

Start: 2013-08-31End: 2014-03-31Updated: 2017-09-05

Safety and Tolerability of Ceftazidime-Avibactam for Pediatric Patients With Suspected or Confirmed Infections

CompletedNCT01893346

PfizerSystemic Infections

Start: 2013-07-31End: 2014-10-31Updated: 2017-09-06

A Phase I Study to Assess the Safety, Tolerability and PK of Ceftazidime-Avibactam in Healthy Chinese Subjects

CompletedNCT01920399

PfizerHealthy Volunteers

Start: 2013-10-31End: 2013-11-30Updated: 2017-09-05

Phase 2

Comparative Study of Ceftazidime-Avibactam Versus Standard of Care as Therapy in Febrile Neutropenic Adults With Cancer

TerminatedNCT02732327

Forest LaboratoriesFebrile Neutropenia, Neoplasms

Start: 2016-05-17End: 2016-06-27Updated: 2017-07-21

Phase 3

Compare Ceftazidime-Avibactam + Metronidazole Versus Meropenem for Hospitalized Adults With Complicated Intra-Abdominal Infections

CompletedNCT01499290

PfizerComplicated Intra-Abdominal Infection

Start: 2012-03-31End: 2014-04-30Updated: 2017-09-06

Journal of Antimicrobial Chemotherapy2023-09-1316 citations

Population Pharmacokinetic Modeling and Probability of Pharmacodynamic Target Attainment for Ceftazidime‐Avibactam in Pediatric Patients Aged 3 Months and Older

Clinical Pharmacology & Therapeutics2021-10-2328 citations

Clinical and Microbiological Outcomes of Ceftazidime-Avibactam Treatment in Adults with Gram-Negative Bacteremia: A Subset Analysis from the Phase 3 Clinical Trial Program.

2021-08-1021 citations

Safety Profile of Ceftazidime-Avibactam: Pooled Data from the Adult Phase II and Phase III Clinical Trial Programme.

2020-08-0115 citations

Cost-effectiveness analysis comparing ceftazidime/avibactam (CAZ-AVI) as empirical treatment comparing to ceftolozane/tazobactam and to meropenem for complicated intra-abdominal infection (cIAI).

2019-12-2113 citations

Clinical activity of ceftazidime/avibactam against MDR Enterobacteriaceae and Pseudomonas aeruginosa: pooled data from the ceftazidime/avibactam Phase III clinical trial programme.

2018-09-0161 citations

<i>In Vitro</i> Activity of Ceftazidime-Avibactam against Isolates from Patients in a Phase 3 Clinical Trial for Treatment of Complicated Intra-abdominal Infections

Antimicrobial Agents and Chemotherapy2018-04-1815 citations

Molecular β-Lactamase Characterization of Aerobic Gram-Negative Pathogens Recovered from Patients Enrolled in the Ceftazidime-Avibactam Phase 3 Trials for Complicated Intra-abdominal Infections, with Efficacies Analyzed against Susceptible and Resistant Subsets

Antimicrobial Agents and Chemotherapy2017-03-2838 citations

Phase I Study Assessing the Pharmacokinetic Profile, Safety, and Tolerability of a Single Dose of Ceftazidime-Avibactam in Hospitalized Pediatric Patients

Antimicrobial Agents and Chemotherapy2016-08-0958 citations

Efficacy and Safety of Ceftazidime-Avibactam Plus Metronidazole Versus Meropenem in the Treatment of Complicated Intra-abdominal Infection: Results From a Randomized, Controlled, Double-Blind, Phase 3 Program

Clinical Infectious Diseases2016-03-08376 citations

A Randomized, Phase I Study to Assess the Safety, Tolerability and Pharmacokinetics of Ceftazidime-Avibactam in Healthy Chinese Subjects.

2016-02-0112 citations

Randomized pharmacokinetic and drug–drug interaction studies of ceftazidime, avibactam, and metronidazole in healthy subjects

Pharmacology Research & Perspectives2015-08-2542 citations

CAZ-AVI

Sponsors

Conditions

Phase 1

Phase 2

Phase 3

Related Papers