CARCIK-CD19

BIOLOGICAL2 trials

Sponsors

Fondazione Matilde Tettamanti Menotti De Marchi Onlus

Conditions

Acute Lymphoblastic Leukemia, in RelapseB-cell NHLCLL

Phase 1

Transposon-manipulated Allogeneic CARCIK-CD19 Cells in Pediatric and Adult Patients With r/r ALL Post HSCT

CompletedNCT03389035

Fondazione Matilde Tettamanti Menotti De Marchi OnlusAcute Lymphoblastic Leukemia, in Relapse

Start: 2017-12-20End: 2022-12-30Updated: 2023-05-06

Allogeneic CARCIK-CD19 in Adults/Pediatric B-cell NHL or Chronic Lymphocytic Leukemia

RecruitingNCT05869279

Fondazione Matilde Tettamanti Menotti De Marchi OnlusB-cell NHL, CLL

Start: 2023-12-01End: 2027-09-01Target: 29Updated: 2024-05-03

Related Papers

Optimized GMP-grade production of non-viral Sleeping Beauty-generated CARCIK cells for enhanced fitness and clinical scalability.

2025-05-192 citations

CD19 CAR T Cells Drive a Remodeling of the Immune Microenvironment Associated with T-Cell Dysfunction in Acute Lymphoblastic Leukemia

Blood2024-11-05

Role of Microenvironment in Influencing the Activity of CD19 CAR T Cells in B-Cell Precursor Acute Lymphoblastic Leukemia (B-ALL)

Blood2023-11-02

Final Results of Phase I/II Study of Donor-Derived CAR T Cells Engineered with Sleeping Beauty in Pediatric and Adult Patients with B-Cell Acute Lymphoblastic Leukemia Relapsed Post-HSCT

Blood2022-11-156 citations

Carcik-CD19 Cells Expand In Vivo Toward a CD8+ Memory Phenotype and Their Persistence Is Associated with a Longer Duration of Response

Blood2022-11-152 citations

Donor-Derived CAR T Cells Engineered with Sleeping Beauty in Pediatric and Adult Patients with Acute Lymphoblastic Leukemia Relapsed Post-HSCT

Blood2021-11-053 citations

CARAMBA: a first-in-human clinical trial with SLAMF7 CAR-T cells prepared by virus-free Sleeping Beauty gene transfer to treat multiple myeloma

Gene Therapy2021-04-13169 citations

Donor-Derived CAR T Cells Engineered with Sleeping Beauty Achieve Anti-Leukemic Activity without Severe Toxicity

Blood2020-11-051 citations

Sleeping Beauty–engineered CAR T cells achieve antileukemic activity without severe toxicities

Journal of Clinical Investigation2020-08-11183 citations

Donor-Derived CD19 CAR Cytokine Induced Killer (CIK) Cells Engineered with Sleeping Beauty Transposon for Relapsed B-Cell Acute Lymphoblastic Leukemia (B-ALL)

Blood2019-11-1310 citations

PF436 GMP MANUFACTURING OF ALLOGENEIC CD19 CHIMERIC ANTIGEN RECEPTOR (CAR) CYTOKINE INDUCED KILLER (CIK) CELLS WITH SLEEPING BEAUTY (SB) TRANSPOSON FOR ADOPTIVE IMMUNOTHERAPY

HemaSphere2019-06-01

Clinical-Grade Transduction of Allogeneic Cytokine Induced Killer (CIK) Cells with CD19 Chimeric Antigen Receptor (CAR) Using Sleeping Beauty (SB) Transposon: Successful GMP-Compliant Manufacturing for Clinical Applications

Blood2018-11-291 citations