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carboxylesterase-expressing allogeneic neural stem cells

BIOLOGICAL2 trials

Sponsors

City of Hope Medical Center

Conditions

Adult Anaplastic AstrocytomaAdult Anaplastic OligodendrogliomaAdult Giant Cell GlioblastomaAdult GlioblastomaAdult GliosarcomaRecurrent Adult Brain TumorRecurrent Anaplastic AstrocytomaRecurrent Anaplastic Oligoastrocytoma

Phase 1

Genetically Modified Stem Cells and Irinotecan Hydrochloride in Treating Patients With Recurrent High-Grade Gliomas
WithdrawnNCT02055196
City of Hope Medical CenterAdult Anaplastic Astrocytoma, Adult Anaplastic Oligodendroglioma, Adult Giant Cell Glioblastoma +3
Updated: 2014-06-02
Carboxylesterase-Expressing Allogeneic Neural Stem Cells and Irinotecan Hydrochloride in Treating Patients With Recurrent High-Grade Gliomas
Active, not recruitingNCT02192359
City of Hope Medical CenterRecurrent Anaplastic Astrocytoma, Recurrent Anaplastic Oligoastrocytoma, Recurrent Anaplastic Oligodendroglioma +4
Start: 2016-04-05End: 2026-09-25Updated: 2026-05-11

Related Papers

STEM-32. PRE-CLINICAL SAFETY AND EFFICACY STUDIES OF NEURAL STEM CELL MEDIATED CARBOXYLESTERASE/IRINOTECAN ENZYME/PRODRUG GENE THERAPY FOR RECURRENT GLIOMA LEADING TO FIRST-IN-HUMAN PHASE I CLINICAL TRIAL
Neuro-Oncology2017-11-01
Getting More Skin in the Game: Using Human Neural Stem Cells Transdifferentiated From Fibroblasts to Target Malignant Gliomas
Neurosurgery2017-08-011 citations