Carboplatin Kabi 10 mg/ml Konzentrat zur Herstellung einer Infusionslösung
Sponsors
Merck Sharp & Dohme LLC, Dizal (Jiangsu) Pharmaceutical Co. Ltd., Janssen Cilag International, Revolution Medicines Inc., Bio-Thera Solutions Ltd.
Conditions
Advanced non-small cell lung cancer with HER2 (ERBB2) mutationFIGO stage III/IV (except FIGO IIIA2 without nodal involvement)First-line treatment of participants with metastatic nonsmall cell lung cancerHead and Neck Squamous Cell CarcinomaLocally Advanced or Metastatic Non-Small Cell Lung Cancer Harboring Epidermal Growth Factor Receptor Exon 20 Insertion MutationLung CancerLung cancerNon-Small Cell Lung Cancer
Phase 1
A Phase 1b/2, Open-label Study of Amivantamab Monotherapy and Amivantamab in Addition to Other Therapeutic Agents in Participants with Head and Neck Squamous Cell Carcinoma
OrigAMI-4
RecruitingCTIS2023-508418-40-00
Start: 2024-12-16Target: 55Updated: 2026-01-19
Study of RMC-6291, With or Without RMC-6236, in Combination With Other Anti-Cancer Agents, in Patients With RAS G12C-Mutated Non-Small Cell Lung Cancer – Subprotocol A
RecruitingCTIS2023-509571-16-00
Start: 2024-07-17Target: 162Updated: 2025-12-17
A Phase 1b/2 Open-Label, Multicenter Study of RMC-6236 in Combination with Pembrolizumab with or without Chemotherapy, in Patients with RAS‑Mutated Non-Small Cell Lung Cancer (NSCLC) – Subprotocol B
RecruitingCTIS2023-509572-42-00
Start: 2024-07-17Target: 180Updated: 2026-01-13
Phase 2
Exploratory study evaluating the potential of immune signature profiling for predicting response in patients with resectable Stage II, IIIA and select IIIB (T3N2 only) non-squamous Non-Small Cell Lung Cancer (NSCLC) to neoadjuvant ATEZOLIZUMAB plus Carboplatin/Nab Paclitaxel (IReP)
Active, not recruitingCTIS2024-516590-75-00
Start: 2021-02-22Target: 20Updated: 2024-09-18
A randomized phase II trial of Mirvetuximab soravtansine (IMGN853), in folate receptor alpha (FRα) high recurrent ovarian cancer eligible for platinum-based chemotherapy.
supported by:
DIAGNOSTIC PROTOCOL for the VENTANA FOLR1 (FOLR1-2.1) CDx Assay Ventana No. RD004881; Protocol Document No. D152967
Active, not recruitingCTIS2024-516959-40-00
Start: 2021-08-17Target: 136Updated: 2025-12-05
Phase 3
A Phase 3 Randomized, Open-label Clinical Study to Evaluate the Pharmacokinetics and Safety of Subcutaneous Pembrolizumab Coformulated With Hyaluronidase (MK-3475A) Versus Intravenous Pembrolizumab, Administered With Chemotherapy, in the First-line Treatment of Participants With Metastatic Non-small Cell Lung Cancer
Active, not recruitingCTIS2022-501506-36-00
Start: 2023-04-11Target: 100Updated: 2025-08-20
A Phase 3, Open-Label, Randomized, Multi-Center Study of DZD9008 versus Platinum-Based Doublet Chemotherapy as First-Line Treatment for Patients with Locally Advanced or Metastatic Non-Small Cell Lung Cancer Harboring Epidermal Growth Factor Receptor Exon 20 Insertion Mutation
RecruitingCTIS2022-502959-54-00
Start: 2023-09-26Target: 65Updated: 2025-08-04
A Phase I/III, Multi-center, Randomized, Double-blind Study of BAT3306 plus Chemotherapy versus Keytruda® plus Chemotherapy to Evaluate Pharmacokinetics, Efficacy, and Safety in Participants with Stage IV Non-squamous Non-small Cell Lung Cancer.
CompletedCTIS2024-510640-32-00
Start: 2024-10-16End: 2025-05-08Target: 23Updated: 2025-03-13
A Phase III, Randomised, Open-Label Study of Savolitinib in Combination With Osimertinib Versus Platinum-Based Doublet Chemotherapy in Participants With EGFR Mutated MET-Overexpressed and/or Amplified, Locally Advanced or Metastatic Non-Small Cell Lung Cancer Who Have Progressed on Treatment With Osimertinib (SAFFRON)
Active, not recruitingCTIS2024-511169-12-00
Start: 2023-03-28Target: 87Updated: 2025-11-17
(22615 SOHO-02) A Phase 3 open-label, randomized, active-controlled, multicenter trial to evaluate the efficacy and safety of orally administered BAY 2927088 compared with standard of care as a first-line therapy in patients with locally advanced or metastatic non-small cell lung cancer (NSCLC) with HER2-activating mutations
RecruitingCTIS2024-511319-91-00
Start: 2024-10-23Target: 145Updated: 2025-08-26
Niraparib vs Niraparib in combination with Bevacizumab in patients with carboplatinum-taxane based chemotherapy in advanced ovarian cancer (A multicentre randomised phase III trial)
RecruitingCTIS2024-516066-11-00
Start: 2022-08-31Target: 970Updated: 2025-11-21
A Phase I-III, Multicenter Study Evaluating the Efficacy and Safety of Multiple Therapies in Cohorts of Patients with Resectable Stage I-III Non-Small Cell Lung Cancer, selected according to Biomarker Status
RecruitingCTIS2024-511239-91-00
Start: 2025-05-05Target: 54Updated: 2025-11-10
A PHASE III, RANDOMIZED, OPEN-LABEL STUDY EVALUATING THE EFFICACY AND SAFETY OF DIVARASIB AND PEMBROLIZUMAB VERSUS PEMBROLIZUMAB AND PEMETREXED AND CARBOPLATIN OR CISPLATIN IN PATIENTS WITH PREVIOUSLY UNTREATED, KRAS G12C-MUTATED, ADVANCED OR METASTATIC NON-SQUAMOUS NON-SMALL CELL LUNG CANCER
RecruitingCTIS2024-518365-10-00
Start: 2025-10-28Target: 282Updated: 2026-01-13