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Carboplatin Kabi 10 mg/ml Konzentrat zur Herstellung einer Infusionslösung

DRUG13 trials

Sponsors

Merck Sharp & Dohme LLC, Dizal (Jiangsu) Pharmaceutical Co. Ltd., Janssen Cilag International, Revolution Medicines Inc., Bio-Thera Solutions Ltd.

Conditions

Advanced non-small cell lung cancer with HER2 (ERBB2) mutationFIGO stage III/IV (except FIGO IIIA2 without nodal involvement)First-line treatment of participants with metastatic nonsmall cell lung cancerHead and Neck Squamous Cell CarcinomaLocally Advanced or Metastatic Non-Small Cell Lung Cancer Harboring Epidermal Growth Factor Receptor Exon 20 Insertion MutationLung CancerLung cancerNon-Small Cell Lung Cancer

Phase 1

Phase 2

Phase 3

A Phase 3 Randomized, Open-label Clinical Study to Evaluate the Pharmacokinetics and Safety of Subcutaneous Pembrolizumab Coformulated With Hyaluronidase (MK-3475A) Versus Intravenous Pembrolizumab, Administered With Chemotherapy, in the First-line Treatment of Participants With Metastatic Non-small Cell Lung Cancer
Active, not recruitingCTIS2022-501506-36-00
Merck Sharp & Dohme LLCFirst-line treatment of participants with metastatic nonsmall cell lung cancer
Start: 2023-04-11Target: 100Updated: 2025-08-20
A Phase 3, Open-Label, Randomized, Multi-Center Study of DZD9008 versus Platinum-Based Doublet Chemotherapy as First-Line Treatment for Patients with Locally Advanced or Metastatic Non-Small Cell Lung Cancer Harboring Epidermal Growth Factor Receptor Exon 20 Insertion Mutation
RecruitingCTIS2022-502959-54-00
Dizal (Jiangsu) Pharmaceutical Co. Ltd.Locally Advanced or Metastatic Non-Small Cell Lung Cancer Harboring Epidermal Growth Factor Receptor Exon 20 Insertion Mutation
Start: 2023-09-26Target: 65Updated: 2025-08-04
A Phase I/III, Multi-center, Randomized, Double-blind Study of BAT3306 plus Chemotherapy versus Keytruda® plus Chemotherapy to Evaluate Pharmacokinetics, Efficacy, and Safety in Participants with Stage IV Non-squamous Non-small Cell Lung Cancer.
CompletedCTIS2024-510640-32-00
Bio-Thera Solutions Ltd.Stage IV Non-squamous non-small cell lung cancer
Start: 2024-10-16End: 2025-05-08Target: 23Updated: 2025-03-13
A Phase III, Randomised, Open-Label Study of Savolitinib in Combination With Osimertinib Versus Platinum-Based Doublet Chemotherapy in Participants With EGFR Mutated MET-Overexpressed and/or Amplified, Locally Advanced or Metastatic Non-Small Cell Lung Cancer Who Have Progressed on Treatment With Osimertinib (SAFFRON)
Active, not recruitingCTIS2024-511169-12-00
AstraZeneca ABNon-Small Cell Lung Cancer
Start: 2023-03-28Target: 87Updated: 2025-11-17
(22615 SOHO-02) A Phase 3 open-label, randomized, active-controlled, multicenter trial to evaluate the efficacy and safety of orally administered BAY 2927088 compared with standard of care as a first-line therapy in patients with locally advanced or metastatic non-small cell lung cancer (NSCLC) with HER2-activating mutations
RecruitingCTIS2024-511319-91-00
Bayer AGAdvanced non-small cell lung cancer with HER2 (ERBB2) mutation
Start: 2024-10-23Target: 145Updated: 2025-08-26
Niraparib vs Niraparib in combination with Bevacizumab in patients with carboplatinum-taxane based chemotherapy in advanced ovarian cancer (A multicentre randomised phase III trial)
RecruitingCTIS2024-516066-11-00
AGO Research GmbHFIGO stage III/IV (except FIGO IIIA2 without nodal involvement), histologically confirmed, or fallopian tube cancer +5
Start: 2022-08-31Target: 970Updated: 2025-11-21
A Phase I-III, Multicenter Study Evaluating the Efficacy and Safety of Multiple Therapies in Cohorts of Patients with Resectable Stage I-III Non-Small Cell Lung Cancer, selected according to Biomarker Status
RecruitingCTIS2024-511239-91-00
F. Hoffmann-La Roche AGResectable Stage I-III Non-Small Cell Lung Cancer (NSCLC)
Start: 2025-05-05Target: 54Updated: 2025-11-10
A PHASE III, RANDOMIZED, OPEN-LABEL STUDY EVALUATING THE EFFICACY AND SAFETY OF DIVARASIB AND PEMBROLIZUMAB VERSUS PEMBROLIZUMAB AND PEMETREXED AND CARBOPLATIN OR CISPLATIN IN PATIENTS WITH PREVIOUSLY UNTREATED, KRAS G12C-MUTATED, ADVANCED OR METASTATIC NON-SQUAMOUS NON-SMALL CELL LUNG CANCER
RecruitingCTIS2024-518365-10-00
F. Hoffmann-La Roche AGPreviously Untreated Advanced or Metastatic Non-Squamous Non−Small Cell Lung Cancer
Start: 2025-10-28Target: 282Updated: 2026-01-13