Carboplatin Hikma 10 mg/ml Konzentrat zur Herstellung einer Infusionslösung
Sponsors
Regeneron Pharmaceuticals Inc., Blueprint Medicines Corp., Gilead Sciences Inc., Dizal (Jiangsu) Pharmaceutical Co. Ltd., AstraZeneca AB
Conditions
Advanced Non-Small Cell Lung CancerAdvanced Non-small Cell Lung CancerHER2-expressing endometrial cancer (IHC 3+/2+)HR+ Breast Cancer
CCNE1 Amplification
HER2-negative Breast Cancer
Advanced Solid Tumor
Ovarian Cancer
Endometrial Cancer
Gastric CancerHead and Neck Squamous Cell CarcinomaLocally Advanced or Metastatic Non-Small Cell Lung Cancer Harboring Epidermal Growth Factor Receptor Exon 20 Insertion MutationLocally Advanced or Metastatic Urothelial CarcinomaLocoregional Recurrence of Squamous Cell Carcinoma of the Head and Neck (HNSCC)
Phase 1
A Phase 1/2 Study of REGN7075 (EGFRxCD28 Costimulatory Bispecific Antibody) in Combination with Cemiplimab in Patients with Advanced Solid Tumors
RecruitingCTIS2022-501234-37-00
Start: 2024-05-07Target: 212Updated: 2025-09-16
A Phase 1/2 Study to Evaluate the Safety, Pharmacokinetics, and Efficacy of BLU-222 as a Single Agent and in Combination Therapy for Patients with Advanced Solid Tumors
CompletedCTIS2022-502528-29-00
Start: 2024-01-09End: 2025-07-04Target: 50Updated: 2025-06-25
A Phase 1b/2, Open-label, Randomized Study of Vudalimab in Combination With Chemotherapy or Pembrolizumab in Combination With Chemotherapy as First-line Treatment in Patients With Advanced Non-small Cell Lung Cancer
CompletedCTIS2023-509644-10-00
Start: 2024-06-27End: 2025-12-29Target: 116Updated: 2025-11-17
A Phase 1b/2, Open-label Study of Amivantamab Monotherapy and Amivantamab in Addition to Other Therapeutic Agents in Participants with Head and Neck Squamous Cell Carcinoma
OrigAMI-4
RecruitingCTIS2023-508418-40-00
Start: 2024-12-16Target: 55Updated: 2026-01-19
Phase 2
A Phase II, Open-label, Platform Study, to Evaluate Immunotherapy-based Combinations in Participants With Advanced Non-Small Cell Lung Cancer
Active, not recruitingCTIS2022-502916-35-01
Start: 2024-03-27Target: 171Updated: 2025-09-10
A Randomized Phase 2 Platform Study to Evaluate Cemiplimab Plus Chemotherapy Versus Cemiplimab Plus Chemotherapy Plus Other Cancer Treatments for the Perioperative Treatment of Patients with Resectable Non-Small Cell Lung Cancer
RecruitingCTIS2023-509806-31-00
Start: 2025-02-11Target: 40Updated: 2025-11-07
A Phase II, Open-label Study to Evaluate the Safety, Tolerability, Pharmacokinetics, Immunogenicity, and Antitumor Activity of Volrustomig Priming Regimens in Combination with Other Anticancer Agents in Participants with Solid Tumors (eVOLVE 01).
Substudy 1: Volrustomig + Chemotherapy as 1L Treatment in Participants with Advanced or Metastatic NSCLC NSQ
and PD-L1 TPS xx
Substudy 2: Volrustomig + Ramucirumab + Chemotherapy as 1L Treatment in Participants with Advanced or Metastatic
NSCLC SQ or NSQ and PD-L1 TPS xx
RecruitingCTIS2023-509482-20-00
Start: 2024-12-03Target: 91Updated: 2025-10-21
A Phase 2/3, Multicenter Randomized Study of Rituximab-Gemcitabine-
Dexamethasone-Platinum (R-GDP) With or Without Selinexor in Patients with Relapsed/Refractory Diffuse Large B-Cell Lymphoma (RR DLBCL).
Active, not recruitingCTIS2024-513616-95-00
Start: 2020-12-22Target: 60Updated: 2025-10-02
A Randomized, Open-Label, Phase 2/3 Study of Datopotamab Deruxtecan (Dato-DXd) plus Carboplatin or Cisplatin versus Gemcitabine plus Carboplatin or Cisplatin in Participants with Locally Advanced or Metastatic Urothelial Carcinoma (la/mUC) who Progressed During or After Enfortumab Vedotin (EV) plus Pembrolizumab Combination Treatment.
TROPION-Urothelial03 (TU03).
RecruitingCTIS2024-516906-47-00
Start: 2025-11-28Target: 330Updated: 2026-01-12
A Phase 1/2 Study to Evaluate STK-012 as a Single Agent and in Combination Therapy in Subjects with Front-line Advanced NSCLC and Other Selected Indications
Not yet recruitingCTIS2025-522632-14-00
Target: 56Updated: 2026-01-13
Phase 3
A Phase 3, Open-Label, Randomized, Multi-Center Study of DZD9008 versus Platinum-Based Doublet Chemotherapy as First-Line Treatment for Patients with Locally Advanced or Metastatic Non-Small Cell Lung Cancer Harboring Epidermal Growth Factor Receptor Exon 20 Insertion Mutation
RecruitingCTIS2022-502959-54-00
Start: 2023-09-26Target: 65Updated: 2025-08-04
Randomized, Controlled, Open-label, Phase 3, Global Multi-Center Trial to Assess the Efficacy and Safety of Zipalertinib plus Chemotherapy versus Chemotherapy alone, in Patients with Previously Untreated, Locally Advanced or Metastatic Nonsquamous Non-Small Cell Lung Cancer (NSCLC) with Epidermal Growth Factor Receptor (EGFR) Exon 20 Insertion (ex20ins) Mutations
Active, not recruitingCTIS2023-503575-21-00
Start: 2024-01-23Target: 118Updated: 2025-11-04
A Phase III, Two- Arm, Parallel, Randomized, Multi-Center, Open‑Label, Global Study to Determine the Efficacy of Volrustomig (MEDI5752) in Combination with Chemotherapy Versus Pembrolizumab Plus Chemotherapy for First-Line Treatment of Patients with Metastatic Non-Small Cell Lung Cancer (mNSCLC) (eVOLVE-Lung02)
SuspendedCTIS2023-503298-39-00
Start: 2024-06-13Target: 437Updated: 2025-12-15
BEAMION Lung-2: A Phase III, open-label, randomized, activecontrolled, multi-centre trial evaluating orally administered zongertinib (BI 1810631) compared with standard of care as first-line treatment in patients with unresectable, locally advanced or metastatic nonsquamous non-small cell lung cancer harbouring HER2 tyrosine kinase domain mutations
RecruitingCTIS2023-504308-27-00
Start: 2024-06-06Target: 121Updated: 2025-11-13
LOGGIC/FIREFLY-2: A Phase 3, Randomized, International Multicenter Trial of DAY101 Monotherapy Versus Standard of Care Chemotherapy in Patients with Pediatric Low-Grade Glioma Harboring an Activating RAF Alteration Requiring First-Line Systemic Therapy
RecruitingCTIS2024-510742-13-00
Start: 2023-04-19Target: 245Updated: 2025-11-19
A Double-Blind, Randomized, Active-Controlled, Parallel-Group, Phase 3 Study to Compare Efficacy and Safety of CT-P51 and Keytruda in Combination with Platinum-Pemetrexed Chemotherapy in Patients with Previously Untreated Metastatic Non-Squamous Non-Small Cell Lung Cancer
RecruitingCTIS2024-514048-98-00
Start: 2025-01-30Target: 210Updated: 2025-04-22
A Randomized, Placebo-Controlled, Double-Blind, Multi-Center Phase 3 Study of Zipalertinib Plus Adjuvant Chemotherapy Versus Placebo Plus Adjuvant Chemotherapy in Stage IB-IIIA NSCLC Patients with Uncommon EGFR Mutations Following Complete Tumor Resection (REZILIENT4)
RecruitingCTIS2025-521775-31-00
Start: 2025-11-12Target: 126Updated: 2026-01-12
A Phase 3, Multicenter, Randomized, Open-label Trial of Trastuzumab Deruxtecan Versus Standard of Care Chemotherapy With or Without Radiotherapy as Adjuvant Treatment for HER2-Expressing (IHC 3+/2+) Endometrial Cancer
(DESTINY-Endometrial02/ GOG-3122/ ENGOT-en30/GINECO)
Not yet recruitingCTIS2024-519444-33-00
Target: 200Updated: 2026-01-06
A Phase 3 Multicenter, Randomized, Open-label Study of ASP-1929 Photoimmunotherapy in Combination With Pembrolizumab Versus Standard of Care in the First-line Treatment of Patients With Locoregional Recurrence of Squamous Cell Carcinoma of the Head and Neck (HNSCC) With No Distant Metastases
Not yet recruitingCTIS2025-523017-28-00
Target: 30Updated: 2026-04-03