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Carboplatin 10 mg/ml concentrate for solution for infusion

DRUG20 trials

Sponsors

AstraZeneca AB, Grupo Espanol De Investigacion En Cancer De Mama, Beigene Ltd., Seagen Inc., Gilead Sciences Inc.

Conditions

Advanced Biliary Tract CancersFirst recurrence glioblastomaMetastatic Non-small Cell Lung CancerMetastatic Squamous Non-small Cell Lung CancerNeuroblastomaNon-Small Cell Lung CancerNon-small Cell Lung CancerNon-small cell lung cancer

Phase 1

Phase 2

MASTER PROTOCOL: A Phase 2, Open-label, Multi-arm Study of Tislelizumab in Combination With Investigational Agents With or Without Chemotherapy in Patients With Previously Untreated, Locally Advanced, Unresectable, or Metastatic Non-Small Cell Lung Cancer.
Active, not recruitingCTIS2022-502738-18-00
Beigene Ltd.Metastatic Non-small Cell Lung Cancer, Non-small Cell Lung Cancer
Start: 2023-09-15Target: 22Updated: 2025-11-18
OPAL Master Protocol: A Phase 1B/2 Multicohort Umbrella Study to Evaluate the Safety and Efficacy of Novel Treatments and/or Combinations of Treatments in Participants with Ovarian Cancer (OPAL) (PR-3000-02-005/213357) Cohort C: Open-label Phase 2, Randomized, Controlled Multicenter Study Comparing Niraparib Versus Platinum-Taxane Doublet Chemotherapy as Neoadjuvant Treatment in Participants with Homologous Recombination- Deficient Stage III/IV Ovarian Cancer
CompletedCTIS2023-505097-16-00
Tesaro Inc.Ovarian Neoplasms
Start: 2022-04-04End: 2025-03-31Target: 15Updated: 2025-01-14
A Phase II, Open-label, Single-arm Study of Osimertinib as Induction Therapy Prior to CRT and Maintenance Osimertinib in Patients with Epidermal Growth Factor Receptor (EGFR) Mutation-positive, Stage III, Unresectable Non-small Cell Lung Cancer (NEOLA)
Active, not recruitingCTIS2023-507798-16-00
Astrazeneca ABUnresectable Non-small Cell Lung Cancer
Start: 2024-04-16Target: 16Updated: 2025-04-28
An Open-label, Multicenter, Phase 2 Study of Sacituzumab Govitecan Combinations in First-line Treatment of Patients with Advanced or Metastatic Non−Small-Cell Lung Cancer (NSCLC) Without Actionable Genomic Alterations
Active, not recruitingCTIS2024-513225-23-00
Gilead Sciences Inc.Non-small cell lung cancer
Start: 2022-04-07Target: 156Updated: 2025-08-18
A Phase 2 Study of Novel Combination Therapies in Participants With Previously Untreated Recurrent or Metastatic Head and Neck Squamous Cell Carcinoma Regardless of PD-L1 Expression Status
SuspendedCTIS2024-513121-22-00
Gilead Sciences Inc.Recurrent or Metastatic Head and Neck Squamous Cell Carcinoma
Start: 2025-02-04Target: 21Updated: 2026-01-27
A Phase II, Open-Label, Single-Arm, Multicentre Study of Carboplatin, Paclitaxel, and Tislelizumab in Biomarker-Selected Patients with Resectable Locally Advanced Oral Cavity Squamous Cell Carcinoma - PERSEPHONE Trial
Not yet recruitingCTIS2024-517565-16-00
Gruppo Oncologico Del Nord OvestResectable Locally Advanced Oral Cavity Squamous Cell Carcinoma
Target: 28Updated: 2026-01-16

Phase 3

A Phase IIIb, Single Arm, Open-label, Multicentre Study of Durvalumab in Combination with Chemotherapy for the First Line Treatment for Patients with Advanced Biliary Tract Cancers (TOURMALINE)
WithdrawnCTIS2022-502043-35-00
AstraZeneca ABAdvanced Biliary Tract Cancers
Target: 76Updated: 2023-09-04
A randomized, open-label, multicentric, two-arm pivotal trial of SonoCloud-9 combined with carboplatin (CBDCA) vs standard of care lomustine (CCNU) or temozolomide (TMZ) in patients undergoing planned resection for first recurrence glioblastoma
SuspendedCTIS2023-505829-14-00
Carthera, CartheraFirst recurrence glioblastoma
Start: 2023-12-22Target: 289Updated: 2025-09-22
C5701003 - An open-label, randomized, controlled phase 3 study of enfortumab vedotin in combination with pembrolizumab versus chemotherapy alone in previously untreated locally advanced or metastatic urothelial cancer
Active, not recruitingCTIS2023-503421-19-00
Seagen Inc.Urothelial cancer
Start: 2020-08-26Target: 703Updated: 2025-08-19
A Randomized, Controlled, Multiregional Phase 3 Study of Ivonescimab Combined with Chemotherapy Versus Pembrolizumab Combined with Chemotherapy for the First-line Treatment of Metastatic Squamous Non-small Cell Lung Cancer
WithdrawnCTIS2023-504989-37-00
Summit Therapeutics Sub Inc.Metastatic Squamous Non-small Cell Lung Cancer
Target: 135Updated: 2024-01-08
A Phase IIIb, Single Arm, Open-label, Multicentre Study of Durvalumab in Combination with Chemotherapy for the First Line Treatment for Patients with Advanced Biliary Tract Cancers (TOURMALINE)
Active, not recruitingCTIS2022-502043-35-01
AstraZeneca ABAdvanced Biliary Tract Cancers
Start: 2024-04-24Target: 76Updated: 2025-11-26
A Phase III, Randomised, Open-Label Study of Savolitinib in Combination With Osimertinib Versus Platinum-Based Doublet Chemotherapy in Participants With EGFR Mutated MET-Overexpressed and/or Amplified, Locally Advanced or Metastatic Non-Small Cell Lung Cancer Who Have Progressed on Treatment With Osimertinib (SAFFRON)
Active, not recruitingCTIS2024-511169-12-00
AstraZeneca ABNon-Small Cell Lung Cancer
Start: 2023-03-28Target: 87Updated: 2025-11-17
A Randomized, Double-blind, Multiregional Phase 3 Study of Ivonescimab Combined with Chemotherapy Versus Pembrolizumab Combined with Chemotherapy for the First-line Treatment of Metastatic Non-small Cell Lung Cancer (HARMONi-3)
RecruitingCTIS2024-513087-26-00
Summit Therapeutics Inc.Metastatic Non-small Cell Lung Cancer
Start: 2024-09-10Target: 661Updated: 2026-01-26
A Randomized Phase III, Two-Arm Trial of Paclitaxel/Carboplatin/Maintenance Letrozole Versus Letrozole Monotherapy in Patients with Stage II-IV, Primary Low-Grade Serous Carcinoma of the Ovary or Peritoneum.
Active, not recruitingCTIS2024-516530-36-00
Cancer Trials Irelandlow-grade serous carcinoma of the ovary or peritoneum
Start: 2025-01-08Target: 20Updated: 2025-10-14
A Global, Randomized, Phase 3, Open-Label Study of REGN2810 (Anti-PD-1 Antibody) versus Platinum-Based Chemotherapy in First-Line Treatment of Patients with Advanced or Metastatic PD-L1 + Non-Small Cell Lung Cancer
CompletedCTIS2024-515052-20-00
Regeneron Pharmaceuticals Inc.Non-small Cell Lung Cancer
Start: 2017-09-20End: 2025-04-18Target: 68Updated: 2024-12-10
A Two-Part Randomized, Phase 3 Study of Combinations of Cemiplimab (Anti- PD-1 Antibody) and Platinum-based Doublet Chemotherapy in First-line Treatment of Patients with Advanced or Metastatic Non-Small Cell Lung Cancer
CompletedCTIS2024-515051-38-00
Regeneron Pharmaceuticals Inc.Non-small Cell Lung Cancer
Start: 2018-07-20End: 2025-02-27Target: 117Updated: 2024-12-10
A Randomized, Open-label, Phase 3 Study of Sacituzumab Govitecan and Pembrolizumab Versus Treatment of Physician’s Choice and Pembrolizumab in Patients With Previously Untreated, Locally Advanced Inoperable or Metastatic Triple-Negative Breast Cancer, Whose Tumors Express PD-L1
Active, not recruitingCTIS2023-504194-21-00
Gilead Sciences Inc.PD-L1 Positive Metastatic Triple-Negative Breast Cancer
Start: 2022-09-13Target: 114Updated: 2026-01-12
A Randomized, Open-label, Phase 3 Study of Sacituzumab Govitecan Versus Treatment of Physician’s Choice in Patients With Previously Untreated, Locally Advanced, Inoperable or Metastatic Triple-Negative Breast Cancer Whose Tumors Do Not Express PD-L1 or in Patients Previously Treated With Anti-PD-(L)1 Agents in the Early Setting Whose Tumors Do Express PD-L1
Active, not recruitingCTIS2023-504195-14-00
Gilead Sciences Inc.PD-L1-negative metastatic triple-negative breast cancer or PD-L1-positive metastatic triple-negative breast cancer previously treated with an anti-PD-(L)1 agent in the curative setting
Start: 2022-08-31Target: 167Updated: 2025-12-12

Phase 4