CARBO-cell® 10 mg/ml Infusionslösung
Sponsors
Bristol-Myers Squibb International Corporation, Bristol Myers Squibb International Corporation, Bristol-Myers Squibb Services Unlimited Company, Gilead Sciences Inc., Janssen - Cilag International
Conditions
Advanced Non-Small Cell Lung CancerEarly Stage Non-Small Cell Lung Cancer (NSCLC)Head and Neck Squamous Cell CarcinomaLocally Advanced or Metastatic Non-Small Cell Lung CancerLung CancerNon-Small Cell Lung CancerPreviously Untreated Advanced or Metastatic Non-Squamous Non−Small Cell Lung CancerPreviously Untreated Locally Advanced Non-small Cell Lung Cancer (LA NSCLC)
Phase 1
A Phase Ib/II, Open-Label, Multicenter Study Evaluating the Safety, Activity, and Pharmacokinetics of Divarasib in Combination with Other Anti-Cancer Therapies in Patients with Previously Untreated Advanced or Metastatic Non-Small Cell Lung Cancer with a KRAS G12C Mutation
RecruitingCTIS2023-507171-22-00
Start: 2023-06-21Target: 116Updated: 2025-10-27
A Phase 1b/2, Open-label Study of Amivantamab Monotherapy and Amivantamab in Addition to Other Therapeutic Agents in Participants with Head and Neck Squamous Cell Carcinoma
OrigAMI-4
RecruitingCTIS2023-508418-40-00
Start: 2024-12-16Target: 55Updated: 2026-01-19
Study of RMC-6291, With or Without RMC-6236, in Combination With Other Anti-Cancer Agents, in Patients With RAS G12C-Mutated Non-Small Cell Lung Cancer – Subprotocol A
RecruitingCTIS2023-509571-16-00
Start: 2024-07-17Target: 162Updated: 2025-12-17
A Phase 1b/2 Open-Label, Multicenter Study of RMC-6236 in Combination with Pembrolizumab with or without Chemotherapy, in Patients with RAS‑Mutated Non-Small Cell Lung Cancer (NSCLC) – Subprotocol B
RecruitingCTIS2023-509572-42-00
Start: 2024-07-17Target: 180Updated: 2026-01-13
Phase 2
Phase 3
A Phase 3, Randomized, Open Label Study to Compare Nivolumab plus Concurrent Chemoradiotherapy (CCRT) followed by Nivolumab plus Ipilimumab or Nivolumab plus CCRT Followed by Nivolumab vs CCRT followed by Durvalumab in Previously Untreated, Locally Advanced Nonsmall Cell Lung Cancer (LA NSCLC)
CompletedCTIS2022-502886-71-00
Start: 2019-11-20End: 2024-05-31Target: 485Updated: 2024-05-20
Randomized, Open-Label, Phase 3 Trial of Nivolumab plus Ipilimumab or Nivolumab plus Platinum-Doublet Chemotherapy versus Platinum-Doublet
Chemotherapy in Early Stage NSCLC
CompletedCTIS2022-501360-18-00
Start: 2017-03-15End: 2024-12-03Target: 194Updated: 2024-12-03
A Phase 3, Randomized, Double-blind Study of Neoadjuvant Chemotherapy plus Nivolumab versus Neoadjuvant Chemotherapy plus Placebo, followed by Surgical Resection and Adjuvant Treatment with Nivolumab or Placebo for Participants with Resectable Stage II-IIIB Non-small Cell Lung Cancer (CheckMate 77T, CHECKpoint pathway and nivoluMAb clinical Trial Evaluation 77T)
Active, not recruitingCTIS2022-502658-15-00
Start: 2019-09-22Target: 252Updated: 2025-10-08
A Phase 3, Open-Label, Randomized Study of Amivantamab and Lazertinib in
Combination with Platinum-Based Chemotherapy Compared with Platinum-Based
Chemotherapy in Patients with EGFR-Mutated Locally Advanced or Metastatic Non-
Small Cell Lung Cancer After Osimertinib Failure
Active, not recruitingCTIS2023-506518-33-00
Start: 2021-11-10Target: 259Updated: 2025-11-13
A Phase 3, Open-label, Randomized Study of Nivolumab Combined with Ipilimumab, or with Standard of Care Chemotherapy, versus Standard of Care Chemotherapy in Participants with Previously Untreated Unresectable or Metastatic Urothelial Cancer
Active, not recruitingCTIS2022-501784-40-00
Start: 2017-05-26Target: 701Updated: 2026-01-26
A Phase III, Randomised, Open-Label Study of Savolitinib in Combination With Osimertinib Versus Platinum-Based Doublet Chemotherapy in Participants With EGFR Mutated MET-Overexpressed and/or Amplified, Locally Advanced or Metastatic Non-Small Cell Lung Cancer Who Have Progressed on Treatment With Osimertinib (SAFFRON)
Active, not recruitingCTIS2024-511169-12-00
Start: 2023-03-28Target: 87Updated: 2025-11-17
A Phase I-III, Multicenter Study Evaluating the Efficacy and Safety of Multiple Therapies in Cohorts of Patients with Resectable Stage I-III Non-Small Cell Lung Cancer, selected according to Biomarker Status
RecruitingCTIS2024-511239-91-00
Start: 2025-05-05Target: 54Updated: 2025-11-10
A PHASE III, RANDOMIZED, OPEN-LABEL STUDY EVALUATING THE EFFICACY AND SAFETY OF DIVARASIB AND PEMBROLIZUMAB VERSUS PEMBROLIZUMAB AND PEMETREXED AND CARBOPLATIN OR CISPLATIN IN PATIENTS WITH PREVIOUSLY UNTREATED, KRAS G12C-MUTATED, ADVANCED OR METASTATIC NON-SQUAMOUS NON-SMALL CELL LUNG CANCER
RecruitingCTIS2024-518365-10-00
Start: 2025-10-28Target: 282Updated: 2026-01-13