CAPOX chemotherapy

DRUG7 trials

Conditions

Locally Advanced Colon CancerLocally Advanced Low Rectal AdenocarcinomaLocally Advanced Rectal Cancer (LARC)Microsatellite Stable (MSS) Colon CancerNeoadjuvant ChemotherapyRadiation OncologyRectal CancerpMMR (Microsatellite Stable Rectal Cancer)

Phase 1

Epacadostat (INCB024360) Added to Preoperative Chemoradiation in Patients With Locally Advanced Rectal Cancer

RecruitingNCT03516708

Washington University School of MedicineRectal Cancer

Start: 2020-01-06End: 2030-08-12Target: 49Updated: 2026-02-11

Serine/Glycine-Restricted Diet With Chemoradiotherapy for Rectal Cancer

Not yet recruitingNCT07811076

Xuelei Ma MDLocally Advanced Rectal Cancer (LARC)

Start: 2026-08-31End: 2029-06-30Target: 140Updated: 2026-09-09

Phase 2

Node-Sparing Short-Course Radiation with CAPOX and Sintilimab for MSS Locally Advanced Colon Cancer: a Randomized, Prospective, Multicenter Study

Not yet recruitingNCT06594692

Sir Run Run Shaw HospitalLocally Advanced Colon Cancer, Microsatellite Stable (MSS) Colon Cancer

Start: 2024-10-31End: 2026-09-30Target: 140Updated: 2024-09-19

A Single-center, Phase II Study on Efficacy & Safety of SCRT+CAPOX+Serplulimab+Bevacizumab for MSS Rectal Cancer

RecruitingNCT07347951

First Affiliated Hospital of Wenzhou Medical UniversityLocally Advanced Rectal Cancer (LARC)

Start: 2025-12-01End: 2030-12-01Target: 30Updated: 2026-01-16

Phase 3

Comparison of the Pathological Effect Between 2 and 4 Cycles Neoadjuvant CAPOX for Low/Intermediate Risk II/III Rectal Cancer

Active, not recruitingNCT04922853

West China HospitalNeoadjuvant Chemotherapy, Rectal Cancer

Start: 2021-08-26End: 2027-12-01Target: 554Updated: 2025-07-11

PD-1 + FOLFOXIRI vs CAPOX as Total Neoadjuvant Therapy for pMMR Low Rectal Cancer

Not yet recruitingNCT07277842

Sun Yat-sen UniversityLocally Advanced Low Rectal Adenocarcinoma, pMMR (Microsatellite Stable Rectal Cancer)

Start: 2025-12-29End: 2028-12-29Target: 382Updated: 2025-12-11

Unknown Phase

Chemotherapy and Tislelizumab With Split-course HFRT for Locally Advanced Rectal Cancer

NCT05176964

Fujian Medical University Union HospitalRadiation Oncology, Rectal Cancer

Start: 2021-12-31End: 2025-12-31Target: 50Updated: 2023-09-25

Journal of Clinical Oncology2026-01-10

Phase II study of epacadostat (INCB024360) added to preoperative chemoradiation in patients with locally advanced rectal cancer.

Journal of Clinical Oncology2025-05-28

COPEC trial: Early determination of pathological tumor response to neoadjuvant chemotherapy in low/intermediate risk stage II/II rectal cancer—A multicenter, non-inferiority phase III randomized trial.

Journal of Clinical Oncology2025-05-28

Prospective Determination of Tumor Regression Grade with Magnetic Resonance Imaging in Neoadjuvant Chemotherapy for Rectal Adenocarcinoma

Proceedings on CD-ROM - International Society for Magnetic Resonance in Medicine. Scientific Meeting and Exhibition/Proceedings of the International Society for Magnetic Resonance in Medicine, Scientific Meeting and Exhibition2024-11-26

Circulating tumor DNA as a predictor of treatment response to neoadjuvant chemotherapy in stage 2/3 rectal cancer without high risks: Subset analysis from the COPEC trial.

Journal of Clinical Oncology2024-06-01

Abstract CT130: Epacadostat with preoperative chemoradiation in locally advanced rectal cancer (LARC): Results of a translational phase I clinical trial

Cancer Research2024-04-05

Comparison of the pathological response to 2 or 4 cycles of neoadjuvant CAPOX in II/III rectal cancer patients with low/intermediate risks: study protocol for a prospective, non-inferior, randomized control trial (COPEC trial).

2023-06-134 citations

Combining chemotherapy and tislelizumab with preoperative split-course hypofraction radiotherapy for locally advanced rectal cancer: study protocol of a prospective, single-arm, phase II trial

BMJ Open2023-03-015 citations

Abstract CT234: Phase I study of epacadostat added to preoperative chemoradiation in patients with locally advanced rectal cancer

Cancer Research2020-08-15