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Caloric Restriction (CR)

BEHAVIORAL6 trials

Sponsors

National Institute on Aging (NIA), Duke University, University of Florida, University of Minnesota

Conditions

AgingCardiovascular DiseaseDiabetes MellitusDiabetes Mellitus, Type 2NAFLDObesity

Phase 1

CALERIE (Washington University): Comprehensive Assessment of Long-term Effects of Reducing Intake of Energy
CompletedNCT00099138
National Institute on Aging (NIA)Aging
Start: 2002-03-31End: 2006-02-28Target: 48Updated: 2009-12-11
CALERIE (Tufts) - Comprehensive Assessment of Long-term Effects of Reducing Intake of Energy
CompletedNCT00099099
National Institute on Aging (NIA)Aging
Start: 2002-03-31End: 2004-12-31Target: 44Updated: 2009-12-11

Unknown Phase

CALERIE (PBRC, Baton Rouge) - Comprehensive Assessment of Long-Term Effects of Reducing Intake of Energy
CompletedNCT00099151
National Institute on Aging (NIA)Aging, Cardiovascular Disease, Diabetes Mellitus
Start: 2002-03-31End: 2006-05-31Target: 48Updated: 2009-12-11
CALERIE: Comprehensive Assessment of Long-Term Effects of Reducing Intake of Energy
CompletedNCT00427193
Duke UniversityAging
Start: 2007-05-31End: 2012-11-30Updated: 2022-03-16
RCT of Caloric Restriction vs. Alternate-Day Fasting in Non-Alcoholic Fatty Liver Disease
TerminatedNCT03365531
University of FloridaDiabetes Mellitus, Type 2, NAFLD, Obesity
Start: 2018-03-01End: 2019-07-01Updated: 2019-09-23
Prolonged Daily Fasting as a Viable Alternative to Caloric Restriction in At-Risk Obese Humans
CompletedNCT04259632
University of MinnesotaObesity
Start: 2020-10-15End: 2025-12-31Updated: 2026-01-23

Related Papers

Diet quality and nutritional adequacy during a 2-year calorie restriction intervention: the Comprehensive Assessment of Long-Term Effects of Reducing Intake of Energy 2 trial.
2025-12-29
Post-intervention sustainability of time-restricted eating versus caloric restriction: a secondary analysis.
2025-11-28
Association between physical activity energy expenditure and markers of healthspan during prolonged calorie restriction in individuals without obesity: observations from the CALERIE™ phase 2 randomized controlled trial
International Journal of Behavioral Nutrition and Physical Activity2025-10-07
A 2-year calorie restriction intervention may reduce glycomic biological age biomarkers – a pilot study
npj Aging2025-08-013 citations
The CALERIE Genomic Data Resource.
2024-12-137 citations
Prediction of individual weight loss using supervised learning: findings from the CALERIE<sup>TM</sup> 2 study.
2024-09-112 citations
Reduction of SPARC protects mice against NLRP3 inflammasome activation and obesity
Journal of Clinical Investigation2023-10-0124 citations
No Effect of Calorie Restriction or Dietary Patterns on Spatial Working Memory During a 2-Year Intervention: A Secondary Analysis of the CALERIE Trial.
2023-01-148 citations
Effect of 2 years of calorie restriction on liver biomarkers: results from the CALERIE phase 2 randomized controlled trial.
2020-08-1423 citations
Best (but oft-forgotten) practices: identifying and accounting for regression to the mean in nutrition and obesity research
American Journal of Clinical Nutrition2019-07-2529 citations
2 years of calorie restriction and cardiometabolic risk (CALERIE): exploratory outcomes of a multicentre, phase 2, randomised controlled trial.
2019-07-11297 citations
Simulating long-term human weight-loss dynamics in response to calorie restriction.
2018-04-0124 citations
Body-composition changes in the Comprehensive Assessment of Long-term Effects of Reducing Intake of Energy (CALERIE)-2 study: a 2-y randomized controlled trial of calorie restriction in nonobese humans.
2017-02-2296 citations
Application of the Marginal Structural Model to Account for Suboptimal Adherence in a Randomized Controlled Trial.
2016-11-0315 citations
Effect of Calorie Restriction on Mood, Quality of Life, Sleep, and Sexual Function in Healthy Nonobese Adults
JAMA Internal Medicine2016-05-02200 citations
The doubly labeled water method produces highly reproducible longitudinal results in nutrition studies.
2014-02-1241 citations
Energy requirements in nonobese men and women: results from CALERIE.
2013-11-2052 citations
Caloric restriction alters the metabolic response to a mixed-meal: results from a randomized, controlled trial.
2012-04-1638 citations
Metabolic and behavioral compensations in response to caloric restriction: implications for the maintenance of weight loss.
2009-02-09222 citations
Calorie restriction and bone health in young, overweight individuals.
2008-09-0169 citations