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Caelyx pegylated liposomal 2 mg/ml concentrate for solution for infusion

DRUG9 trials

Sponsors

Immunogen Inc., Bristol Myers Squibb International Corporation, Verastem Inc., Exscientia AI Limited, Sutro Biopharma Inc.

Conditions

Advanced Epithelial Ovarian Cancer (including Fallopian Tube or Primary Peritoneal cancers)Advanced solid tumorsPlatinum-Resistant Advanced High-Grade Epithelial OvarianPlatinum-resistant High-grade Serous OvarianPlatinum-sensitive epithelial ovarianPrimary PeritonealRecurrent Low-Grade Serous Ovarian Cancer (LGSOC)This trial evaluates the efficacy and safety of Mirvetuximab soravtansine (IMGN853) plus Carboplatin chemotherapy in FRα high patients with recurrent ovarian cancer who are eligible for platinum-based chemotherapy.

Phase 1

Phase 2

A Phase 2 Open-label Randomized Study of Farletuzumab Ecteribulin (MORAb-202), a Folate Receptor Alpha-targeting Antibody-Drug Conjugate, vs Investigator's Choice Chemotherapy in Women with Platinum-resistant High-grade Serous (HGS) Ovarian, Primary Peritoneal, or Fallopian Tube Cancer
CompletedCTIS2023-504111-33-00
Bristol Myers Squibb International Corporationor Fallopian Tube Cancer, Platinum-resistant High-grade Serous Ovarian, Primary Peritoneal
Start: 2023-02-14End: 2025-09-10Target: 55Updated: 2025-09-08
REFRaME-O1: A Phase 2/3 Open-label Study Evaluating the Efficacy and Safety of Luveltamab Tazevibulin (STRO-002) versus Investigator’s Choice (IC) Chemotherapy in Women with Relapsed Platinum-resistant Epithelial Ovarian Cancer (Including Fallopian Tube or Primary Peritoneal Cancers) Expressing Folate Receptor Alpha (FOLR1)
CompletedCTIS2024-512477-27-00
Sutro Biopharma Inc.Advanced Epithelial Ovarian Cancer (including Fallopian Tube or Primary Peritoneal cancers)
End: 2025-03-28Target: 193Updated: 2025-04-18
A randomized phase II trial of Mirvetuximab soravtansine (IMGN853), in folate receptor alpha (FRα) high recurrent ovarian cancer eligible for platinum-based chemotherapy. supported by: DIAGNOSTIC PROTOCOL for the VENTANA FOLR1 (FOLR1-2.1) CDx Assay Ventana No. RD004881; Protocol Document No. D152967
Active, not recruitingCTIS2024-516959-40-00
AGO Research GmbHThis trial evaluates the efficacy and safety of Mirvetuximab soravtansine (IMGN853) plus Carboplatin chemotherapy in FRα high patients with recurrent ovarian cancer who are eligible for platinum-based chemotherapy.
Start: 2021-08-17Target: 136Updated: 2025-12-05
RECHALLENGE WITH PEGYLATED LIPOSOMAL DOXORUBICIN ADDED TO TRABECTEDIN IN RECURRENT OVARIAN CANCER: A MULTICENTER, PROSPECTIVE TRIAL.(REPRAB study- MITO 36)
Active, not recruitingCTIS2024-518847-40-00
Fondazione Policlinico Universitario Agostino Gemelli IRCCSrecurrent ovarian cancer
Start: 2021-07-16Target: 64Updated: 2025-09-02

Phase 3

2022-501606-35-00 – Randomized, multicenter, open-label, Phase 3 study of mirvetuximab soravtansine in combination with bevacizumab versus bevacizumab alone as maintenance therapy for patients with FRα-high recurrent platinum-sensitive epithelial ovarian, fallopian tube, or primary peritoneal cancers who have not progressed after second-line platinum-based chemotherapy plus bevacizumab (GLORIOSA).
RecruitingCTIS2022-501606-35-01
Immunogen Inc.fallopian tube, or primary peritoneal cancers, Platinum-sensitive epithelial ovarian
Start: 2024-02-21Target: 110Updated: 2026-01-21
A Phase 3, Randomized, Open-Label Study of Combination Therapy with Avutometinib plus Defactinib Versus Investigator’s Choice of Treatment in Patients with Recurrent Low-Grade Serous Ovarian Cancer (LGSOC) (RAMP301)
RecruitingCTIS2023-508204-38-00
Verastem Inc.Recurrent Low-Grade Serous Ovarian Cancer (LGSOC)
Start: 2024-07-02Target: 183Updated: 2026-01-06
MIRASOL: A Randomized, Open-label, Phase 3 Study of Mirvetuximab Soravtansine vs. Investigator’s Choice of Chemotherapy in Platinum- Resistant Advanced High-Grade Epithelial Ovarian, Primary Peritoneal, or Fallopian Tube Cancers with High Folate Receptor-Alpha Expression
CompletedCTIS2024-516111-25-00
Immunogen Inc.or Fallopian Tube Cancers with High Folate Receptor-Alpha Expression, Platinum-Resistant Advanced High-Grade Epithelial Ovarian, Primary Peritoneal
Start: 2020-11-09End: 2024-10-29Target: 1Updated: 2024-10-15
A prospective, open-label, randomized, multicenter phase-III trial to evaluate the efficacy of pirtobrutinib and epcoritamab compared with R-(mini)-CHOP for treatment of patients with Richter Transformation - CLLRT2
Not yet recruitingCTIS2024-513445-37-00
University Of Cologneirrespective of risk factors and disease stage, previously untreated RT
Target: 41Updated: 2026-03-18