Caelyx pegylated liposomal 2 mg/ml concentrate for solution for infusion
Sponsors
Immunogen Inc., Bristol Myers Squibb International Corporation, Verastem Inc., Exscientia AI Limited, Sutro Biopharma Inc.
Conditions
Advanced Epithelial Ovarian Cancer (including Fallopian Tube or Primary Peritoneal cancers)Advanced solid tumorsPlatinum-Resistant Advanced High-Grade Epithelial OvarianPlatinum-resistant High-grade Serous OvarianPlatinum-sensitive epithelial ovarianPrimary PeritonealRecurrent Low-Grade Serous Ovarian Cancer (LGSOC)This trial evaluates the efficacy and safety of Mirvetuximab soravtansine (IMGN853) plus Carboplatin chemotherapy in FRα high patients with recurrent ovarian cancer who are eligible for platinum-based chemotherapy.
Phase 1
Phase 2
A Phase 2 Open-label Randomized Study of Farletuzumab Ecteribulin (MORAb-202), a Folate Receptor Alpha-targeting Antibody-Drug Conjugate, vs Investigator's Choice Chemotherapy in Women with Platinum-resistant High-grade Serous (HGS) Ovarian, Primary Peritoneal, or Fallopian Tube
Cancer
CompletedCTIS2023-504111-33-00
Start: 2023-02-14End: 2025-09-10Target: 55Updated: 2025-09-08
REFRaME-O1: A Phase 2/3 Open-label Study Evaluating the Efficacy and Safety of Luveltamab Tazevibulin (STRO-002) versus Investigator’s Choice (IC) Chemotherapy in Women with Relapsed Platinum-resistant Epithelial Ovarian Cancer (Including Fallopian Tube or Primary Peritoneal Cancers) Expressing Folate Receptor Alpha (FOLR1)
CompletedCTIS2024-512477-27-00
End: 2025-03-28Target: 193Updated: 2025-04-18
A randomized phase II trial of Mirvetuximab soravtansine (IMGN853), in folate receptor alpha (FRα) high recurrent ovarian cancer eligible for platinum-based chemotherapy.
supported by:
DIAGNOSTIC PROTOCOL for the VENTANA FOLR1 (FOLR1-2.1) CDx Assay Ventana No. RD004881; Protocol Document No. D152967
Active, not recruitingCTIS2024-516959-40-00
Start: 2021-08-17Target: 136Updated: 2025-12-05
RECHALLENGE WITH PEGYLATED LIPOSOMAL DOXORUBICIN ADDED TO TRABECTEDIN IN RECURRENT OVARIAN CANCER: A MULTICENTER, PROSPECTIVE TRIAL.(REPRAB study- MITO 36)
Active, not recruitingCTIS2024-518847-40-00
Start: 2021-07-16Target: 64Updated: 2025-09-02
Phase 3
2022-501606-35-00 – Randomized, multicenter, open-label, Phase 3 study of mirvetuximab soravtansine in combination with bevacizumab versus bevacizumab alone as maintenance therapy for patients with FRα-high recurrent platinum-sensitive epithelial ovarian, fallopian tube, or primary peritoneal cancers who have not progressed after second-line platinum-based chemotherapy plus bevacizumab (GLORIOSA).
RecruitingCTIS2022-501606-35-01
Start: 2024-02-21Target: 110Updated: 2026-01-21
A Phase 3, Randomized, Open-Label Study of Combination Therapy with Avutometinib plus Defactinib Versus Investigator’s Choice of Treatment in Patients with Recurrent Low-Grade Serous Ovarian Cancer (LGSOC) (RAMP301)
RecruitingCTIS2023-508204-38-00
Start: 2024-07-02Target: 183Updated: 2026-01-06
MIRASOL: A Randomized, Open-label, Phase 3 Study of Mirvetuximab Soravtansine vs. Investigator’s Choice of Chemotherapy in Platinum- Resistant Advanced High-Grade Epithelial Ovarian, Primary Peritoneal, or Fallopian Tube Cancers with High Folate Receptor-Alpha Expression
CompletedCTIS2024-516111-25-00
Start: 2020-11-09End: 2024-10-29Target: 1Updated: 2024-10-15
A prospective, open-label, randomized, multicenter phase-III trial to evaluate the efficacy of pirtobrutinib and epcoritamab compared with R-(mini)-CHOP for treatment of patients with Richter Transformation - CLLRT2
Not yet recruitingCTIS2024-513445-37-00
Target: 41Updated: 2026-03-18