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CABOMETYX 40 mg film-coated tablets

DRUG12 trials

Sponsors

Institut Gustave Roussy, Bristol-Myers Squibb Services Unlimited Company, Institut Bergonie, Fondazione IRCCS Istituto Nazionale Dei Tumori, Universitaetsmedizin Goettingen

Conditions

Advance Radioactive-Iodine Refractory Differentiated Thyroid CancerAdvanced /metastatic sarcomas: undifferentiated pleomorphic sarcomaAdvanced neuroendocrine neoplasias G3 (NEN G3) (excluding SCLC and Merkel cell carcinomas)Hepatocellular carcinomaLocally Advanced or Metastatic Renal Cell Carcinoma with a Clear-Cell Component Who Progressed After 1st Line Treatment with Checkpoint InhibitorsMetastatic renal cell carcinoma (mRCC)Neuroendocrine Neoplasia Neuroendocrine TumorNon small-cell lung cancer

Phase 2

Cabozantinib plus Durvalumab in patients with advanced and chemotherapy-treated bladder carcinoma, of urothelial and non-urothelial histology: an open-label, single-centre, phase 2, single-arm proof-of-concept trial: ARCADIA study
RecruitingCTIS2023-509821-29-00
Fondazione IRCCS Istituto Nazionale Dei Tumoribladder carcinoma of urothelial and non-urothelial histology
Start: 2019-09-25Target: 122Updated: 2025-11-18
Biomarker Phase II Study Of Cabozantinib In Advanced Radioactive-Iodine Refractory Differentiated Thyroid Cancer.
CompletedCTIS2024-511292-15-00
Grupo Espanol De Tumores NeuroendocrinosAdvance Radioactive-Iodine Refractory Differentiated Thyroid Cancer
Start: 2023-05-25End: 2025-11-30Target: 41Updated: 2024-03-05
Pan Tumor Study for Long-term Treatment of Cancer Patients Who Have Participated in BMS sponsored Trials Investigating Nivolumab and Other Cancer Therapies
RecruitingCTIS2023-506914-32-00
Bristol-Myers Squibb Services Unlimited CompanyPan tumor
Start: 2020-05-05Target: 307Updated: 2026-01-19
A phase II, open-label, multicenter trial to investigate the clinical activity and safety of Cabozantinib in combination with avelumab in patients refractory to standard chemotherapy with advanced neuroendocrine neoplasias G3 (NEN G3)
CompletedCTIS2024-513518-37-00
Universitaetsmedizin der Johannes Gutenberg-Universitaet Mainz KöRAdvanced neuroendocrine neoplasias G3 (NEN G3) (excluding SCLC and Merkel cell carcinomas)
Start: 2022-03-15End: 2025-01-03Target: 30Updated: 2024-06-26
A PHASE II, MULTICENTRE, OPEN-LABEL STUDY OF CABOZANTINIB AS 2ND LINE TREATMENT IN SUBJECTS WITH UNRESECTABLE, LOCALLY ADVANCED OR METASTATIC RENAL CELL CARCINOMA WITH A CLEAR-CELL COMPONENT WHO PROGRESSED AFTER 1ST LINE TREATMENT WITH CHECKPOINT INHIBITORS
Active, not recruitingCTIS2024-514479-16-00
Ipsen PharmaLocally Advanced or Metastatic Renal Cell Carcinoma with a Clear-Cell Component Who Progressed After 1st Line Treatment with Checkpoint Inhibitors, Unresectable
Start: 2019-10-28Target: 6Updated: 2025-10-07
CABONEN – a phase II trial of Cabozantinib in patients with advanced, low proliferative NEN G3
Active, not recruitingCTIS2024-510863-50-00
Universitaetsmedizin GoettingenNeuroendocrine Neoplasia Neuroendocrine Tumor
Start: 2021-04-23Target: 45Updated: 2025-11-20
PEMBROCABOSARC : COMBINATION OF PEMBROLIZUMAB AND CABOZANTINIB IN PATIENTS WITH ADVANCED SARCOMAS
RecruitingCTIS2023-509496-16-00
Institut BergonieAdvanced /metastatic sarcomas: undifferentiated pleomorphic sarcoma, osteosarcoma and Ewing sarcoma.
Start: 2022-04-21Target: 99Updated: 2025-06-03
Efficacy and safety of Cabozantinib in patients with hepatocellular carcinoma progressing on or intolerant to prior treatment with immune checkpoint inhibitors: A phase II study (Immunocabo)
CompletedCTIS2024-516972-14-00
Humanitas Mirasole S.p.A.Hepatocellular carcinoma
Start: 2020-01-30End: 2025-06-19Target: 46Updated: 2024-10-28
Phase II single arm study with CABozantinib in Non-Small Cell Lung Cancer patients with MET deregulation
Not yet recruitingCTIS2024-518386-95-02
Fondazione Ricerca TraslazionaleNon small-cell lung cancer
Updated: 2026-01-09

Phase 3

Phase 4