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CABOMETYX 20 mg film-coated tablets

DRUG18 trials

Sponsors

Bristol-Myers Squibb Services Unlimited Company, Het Nederlands Kanker Instituut-Antoni van Leeuwenhoek Ziekenhuis Stichting, Institut Bergonie, Bristol Myers Squibb International Corporation, Fondazione IRCCS Istituto Nazionale Dei Tumori

Conditions

Advance Radioactive-Iodine Refractory Differentiated Thyroid CancerAdvanced /metastatic sarcomas: undifferentiated pleomorphic sarcomaAdvanced neuroendocrine neoplasias G3 (NEN G3) (excluding SCLC and Merkel cell carcinomas)Advanced or Metastatic Renal Cell CarcinomaAdvanced solid tumorHepatocellular carcinomaLocally Advanced or Metastatic Renal Cell Carcinoma with a Clear-Cell Component Who Progressed After 1st Line Treatment with Checkpoint InhibitorsMetastatic Castration-Resistant Prostate Cancer

Phase 2

Cabozantinib plus Durvalumab in patients with advanced and chemotherapy-treated bladder carcinoma, of urothelial and non-urothelial histology: an open-label, single-centre, phase 2, single-arm proof-of-concept trial: ARCADIA study
RecruitingCTIS2023-509821-29-00
Fondazione IRCCS Istituto Nazionale Dei Tumoribladder carcinoma of urothelial and non-urothelial histology
Start: 2019-09-25Target: 122Updated: 2025-11-18
Biomarker Phase II Study Of Cabozantinib In Advanced Radioactive-Iodine Refractory Differentiated Thyroid Cancer.
CompletedCTIS2024-511292-15-00
Grupo Espanol De Tumores NeuroendocrinosAdvance Radioactive-Iodine Refractory Differentiated Thyroid Cancer
Start: 2023-05-25End: 2025-11-30Target: 41Updated: 2024-03-05
A Dutch National Study on behalf of the Center for Personalized Cancer Treatment (CPCT) to Facilitate Patient Access to Commercially Available, Targeted Anti-cancer Drugs to determine the Potential Efficacy in Treatment of Advanced Cancers with a Known Molecular Profile: The Drug Rediscovery Protocol (DRUP trial)
RecruitingCTIS2023-509152-33-00
Het Nederlands Kanker Instituut-Antoni van Leeuwenhoek Ziekenhuis StichtingAdvanced solid tumor, Multiple myeloma, Non-Hodgkin lymphoma +1
Start: 2016-07-25Target: 3000Updated: 2025-12-19
Pan Tumor Study for Long-term Treatment of Cancer Patients Who Have Participated in BMS sponsored Trials Investigating Nivolumab and Other Cancer Therapies
RecruitingCTIS2023-506914-32-00
Bristol-Myers Squibb Services Unlimited CompanyPan tumor
Start: 2020-05-05Target: 307Updated: 2026-01-19
A phase II, open-label, multicenter trial to investigate the clinical activity and safety of Cabozantinib in combination with avelumab in patients refractory to standard chemotherapy with advanced neuroendocrine neoplasias G3 (NEN G3)
CompletedCTIS2024-513518-37-00
Universitaetsmedizin der Johannes Gutenberg-Universitaet Mainz KöRAdvanced neuroendocrine neoplasias G3 (NEN G3) (excluding SCLC and Merkel cell carcinomas)
Start: 2022-03-15End: 2025-01-03Target: 30Updated: 2024-06-26
A PHASE II, MULTICENTRE, OPEN-LABEL STUDY OF CABOZANTINIB AS 2ND LINE TREATMENT IN SUBJECTS WITH UNRESECTABLE, LOCALLY ADVANCED OR METASTATIC RENAL CELL CARCINOMA WITH A CLEAR-CELL COMPONENT WHO PROGRESSED AFTER 1ST LINE TREATMENT WITH CHECKPOINT INHIBITORS
Active, not recruitingCTIS2024-514479-16-00
Ipsen PharmaLocally Advanced or Metastatic Renal Cell Carcinoma with a Clear-Cell Component Who Progressed After 1st Line Treatment with Checkpoint Inhibitors, Unresectable
Start: 2019-10-28Target: 6Updated: 2025-10-07
CABONEN – a phase II trial of Cabozantinib in patients with advanced, low proliferative NEN G3
Active, not recruitingCTIS2024-510863-50-00
Universitaetsmedizin GoettingenNeuroendocrine Neoplasia Neuroendocrine Tumor
Start: 2021-04-23Target: 45Updated: 2025-11-20
PEMBROCABOSARC : COMBINATION OF PEMBROLIZUMAB AND CABOZANTINIB IN PATIENTS WITH ADVANCED SARCOMAS
RecruitingCTIS2023-509496-16-00
Institut BergonieAdvanced /metastatic sarcomas: undifferentiated pleomorphic sarcoma, osteosarcoma and Ewing sarcoma.
Start: 2022-04-21Target: 99Updated: 2025-06-03
Efficacy and safety of Cabozantinib in patients with hepatocellular carcinoma progressing on or intolerant to prior treatment with immune checkpoint inhibitors: A phase II study (Immunocabo)
CompletedCTIS2024-516972-14-00
Humanitas Mirasole S.p.A.Hepatocellular carcinoma
Start: 2020-01-30End: 2025-06-19Target: 46Updated: 2024-10-28
Phase II single arm study with CABozantinib in Non-Small Cell Lung Cancer patients with MET deregulation
Not yet recruitingCTIS2024-518386-95-02
Fondazione Ricerca TraslazionaleNon small-cell lung cancer
Updated: 2026-01-09

Phase 3

A Phase 3, Randomized, Open-Label Study of Nivolumab Combined with Cabozantinib versus Sunitinib in Participants with Previously Untreated, Advanced or Metastatic Renal Cell Carcinoma
Active, not recruitingCTIS2023-509711-83-00
Bristol Myers Squibb International CorporationAdvanced or Metastatic Renal Cell Carcinoma
Start: 2017-10-27Target: 265Updated: 2025-07-16
Strategic treatment Pause of first-line Immune Check point inhibitor + Inhibitor in good or only one adverse prognostic factor in intermediate risk metastatic renal cell carcinoma (mRCC) with an objective response: a randomized, non-inferiority phase III study - SPICI
Active, not recruitingCTIS2024-514644-93-00
Centre Hospitalier Universitaire De BordeauxMetastatic renal cell carcinoma (mRCC) with a good or only one adverse prognostic factor intermediate risk per IMDC score
Start: 2022-12-09Target: 372Updated: 2025-05-27
A Phase 3, Randomized, Open-Label, Controlled Study of Cabozantinib (XL184) in Combination with Atezolizumab vs Second Novel Hormonal Therapy (NHT) in Subjects with Metastatic Castration-Resistant Prostate Cancer
Active, not recruitingCTIS2024-516481-11-00
Exelixis Inc.Metastatic Castration-Resistant Prostate Cancer
Start: 2020-09-22Target: 203Updated: 2025-12-04
A Randomized, Double-Blind, Controlled Phase 3 Study of Cabozantinib in Combination with Nivolumab and Ipilimumab versus Nivolumab and Ipilimumab in Subjects with Previously Untreated Advanced or Metastatic Renal Cell Carcinoma of Intermediate or Poor Risk
Active, not recruitingCTIS2024-515616-47-00
Exelixis Inc.Metastatic Renal Cell Carcinoma
Start: 2019-10-03Target: 338Updated: 2025-10-06
A Randomized, Controlled Phase 3 Study of Cabozantinib (XL184) in Combination with Atezolizumab versus Sorafenib in Subjects with Advanced Hepatocellular Carcinoma Who Have Not Received Previous Systemic Anticancer Therapy
Active, not recruitingCTIS2024-516479-34-00
Exelixis Inc.Hepatocellular carcinoma
Start: 2019-05-17Target: 7Updated: 2025-11-04
A Phase 3, Randomized, Double-Blind, Placebo-Controlled Study of Cabozantinib (XL184) in Subjects with Radioiodine-Refractory Differentiated Thyroid Cancer Who Have Progressed after Prior VEGFR-Targeted Therapy
Active, not recruitingCTIS2024-516478-31-00
Exelixis Inc.progressed thyroid cancer
Start: 2019-06-12Target: 6Updated: 2025-09-16

Phase 4

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