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C134

BIOLOGICAL2 trials

Sponsors

University of Alabama at Birmingham, James Markert, MD

Conditions

Anaplastic Astrocytoma of BrainAstrocytomaAstrocytoma, Grade IIIAstrocytoma, Grade IVGlioblastomaGlioblastoma (GBM)Glioblastoma Multiforme of BrainGliosarcoma of Brain

Phase 1

Trial of C134 in Patients With Recurrent GBM
CompletedNCT03657576
University of Alabama at BirminghamAnaplastic Astrocytoma of Brain, Glioblastoma Multiforme of Brain, Gliosarcoma of Brain
Start: 2019-09-23End: 2025-10-25Updated: 2026-09-03
A Phase IB 2 Dose Trial of IRS-1 HSV C134 (IND 17296) Administered Intratumorally in Patients With Recurrent Malignant Glioma
Active, not recruitingNCT06614855
James Markert, MDAstrocytoma, Astrocytoma, Grade III, Astrocytoma, Grade IV +4
Start: 2025-06-02End: 2028-01-01Target: 12Updated: 2026-08-13

Related Papers

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Cancer Research2024-03-22
Abstract CT541A: Oncolytic viral reshaping of the tumor microenvironment to promote CAR T cell therapy for glioblastoma
Cancer Research2022-06-151 citations