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Bupropion Augmentation

DRUG3 trials

Sponsors

Washington University School of Medicine, Centre for Addiction and Mental Health

Conditions

DementiaDepressionDepression - Major Depressive DisorderGeriatric DepressionLate Life DepressionLate Life Treatment Resistant DepressionMajor Depressive DisorderMild Cognitive Impairment

Phase 2

The BAARD Study : Evaluating a Computerized Approach to Treatment Selection in Older Adults With Treatment Resistant Depression.
Not yet recruitingNCT07810738
Washington University School of MedicineDepression - Major Depressive Disorder, Late Life Treatment Resistant Depression, Treatment Resistant Depression
Start: 2026-10-01End: 2029-09-15Target: 300Updated: 2026-09-09

Phase 4

Optimizing Outcomes of Treatment-Resistant Depression in Older Adults
CompletedNCT02960763
Washington University School of MedicineGeriatric Depression, Late Life Depression, Major Depressive Disorder +2
Start: 2017-02-24End: 2021-09-01Updated: 2024-10-03
RCT of Brain Longitudinal Biomarker Study (OPT-Neuro RCT)
CompletedNCT05531591
Centre for Addiction and Mental HealthDementia, Depression, Geriatric Depression +5
Start: 2019-08-01End: 2024-07-31Updated: 2024-11-25

Related Papers

Cognitive changes in older adults receiving pharmacotherapy for treatment-resistant depression: a secondary analysis of the OPTIMUM randomised controlled trial.
2025-10-01
Antidepressant Augmentation versus Switch in Treatment-Resistant Geriatric Depression
New England Journal of Medicine2023-03-0365 citations