budesonide/formoterol 'as needed' + budesonide placebo bid

DRUG2 trials

Sponsors

AstraZeneca

Conditions

Asthma

Phase 3

A Clinical Study to Evaluate Symbicort Turbuhaler Used 'as Needed' in Adults and Adolescents With Asthma.

CompletedNCT02149199

AstraZenecaAsthma

Start: 2014-07-07End: 2017-08-02Updated: 2019-11-15

A Clinical Study to Evaluate Symbicort Turbuhaler Used 'as Needed' in Adults and Adolescents With Asthma

CompletedNCT02224157

AstraZenecaAsthma

Start: 2014-11-28End: 2017-08-16Updated: 2019-11-25

Related Papers

Positioning As-needed Budesonide–Formoterol for Mild Asthma: Effect of Prestudy Treatment in Pooled Analysis of SYGMA 1 and 2

Annals of the American Thoracic Society2021-05-1223 citations

Efficacy and Safety of As-Needed Budesonide-Formoterol in Adolescents with Mild Asthma.

2021-04-2220 citations

Safety of As-Needed Budesonide-Formoterol in Mild Asthma: Data from the Two Phase III SYGMA Studies

Drug Safety2021-02-0618 citations

Effect of a single day of increased as-needed budesonide-formoterol use on short-term risk of severe exacerbations in patients with mild asthma: a post-hoc analysis of the SYGMA 1 study.

2020-10-0150 citations

Efficacy of as-needed budesonide/formoterol in mild asthma: pooled analysis of SYGMA 1 and 2

2020-09-07

Number needed to treat (NNT) to have an additional patient free from a severe or moderate/severe exacerbation: post-hoc analysis of SYGMA 1 in mild asthma

2019-09-282 citations

Exacerbation risk after night-time waking due to asthma in SYGMA 1

2019-09-282 citations

Late Breaking Abstract - Cost effectiveness of as-needed budesonide/formoterol vs low-dose ICS maintenance therapy in mild asthma patients: A UK perspective

2019-09-28

Risk of a severe exacerbation following higher reliever use: post-hoc analysis of SYGMA 1 in mild asthma

Pneumologie2019-02-193 citations

Late Breaking Abstract - Risk of a severe exacerbation following higher reliever use: post-hoc analysis of SYGMA 1 in mild asthma

2018-09-153 citations

Inhaled Combined Budesonide–Formoterol as Needed in Mild Asthma

New England Journal of Medicine2018-05-16611 citations

As-Needed Budesonide–Formoterol versus Maintenance Budesonide in Mild Asthma

New England Journal of Medicine2018-05-16489 citations

Symbicort® Maintenance and Reliever Therapy (SMART) and the evolution of asthma management within the GINA guidelines.

2018-02-057 citations

Description of the protocol for the PRACTICAL study: a randomised controlled trial of the efficacy and safety of ICS/LABA reliever therapy in asthma

BMJ Open Respiratory Research2017-07-2921 citations

The SYGMA programme of phase 3 trials to evaluate the efficacy and safety of budesonide/formoterol given 'as needed' in mild asthma: study protocols for two randomised controlled trials.

2017-01-1022 citations