BT7480

DRUG2 trials

Sponsors

BicycleTx Limited

Conditions

Advanced Solid TumorAdvanced Solid Tumors

Phase 1

Study BT7480-100 in Patients With Advanced Malignancies Associated With Nectin-4 Expression

Active, not recruitingNCT05163041

BicycleTx LimitedAdvanced Solid Tumor

Start: 2021-11-02End: 2026-12-31Target: 200Updated: 2026-01-15

Phase 2

Bicycle Continued Access Protocol (BiCAP) for Participants Receiving a Bicycle Investigational Product

Not yet recruitingNCT07681674

BicycleTx LimitedAdvanced Solid Tumors

Start: 2026-08-01End: 2030-05-30Target: 16Updated: 2026-07-02

Related Papers

Abstract B014: Characterization of Nectin-4 protein expression in non-small cell lung cancer patients

Molecular Cancer Therapeutics2023-12-01

Abstract CT253: Phase 1/2 study of the safety, pharmacokinetics, and preliminary clinical activity of BT7480 in patients with nectin-4 associated advanced malignancies

Cancer Research2023-04-14

A combined phase I/II study of a novel bicycle tumor-targeted immune cell agonist BT7480 in patients with nectin-4 associated advanced malignancies.

Journal of Clinical Oncology2022-06-012 citations