Brincidofovir
Sponsors
Symbio Pharmaceuticals Ltd., Jazz Pharmaceuticals, SymBio Pharmaceuticals, Emergent BioSolutions, National Institute of Neurological Disorders and Stroke (NINDS)
Conditions
AdenovirusAdenovirus DiseaseAdenovirus InfectionAdenovirus InfectionsAdenovirus viremiaBK Virus InfectionCMVCytomegalovirus Disease
Phase 1
CMX001 in Post-transplant Patients With BK Virus Viruria
CompletedNCT00793598
Start: 2009-11-30End: 2010-10-31Updated: 2021-08-16
Study Evaluating the Bioequivalence of Brincidofovir Form H and Form II Tablets in Healthy Adults
CompletedNCT05935917
Start: 2023-05-30End: 2023-09-27Updated: 2025-01-15
A Phase 1b/2 Study of Intravenous Brincidofovir in Patients With Relapsed or Refractory Lymphoma and Relapsed or Refractory Extranodal Natural Killer/T-cell Lymphoma
SuspendedNCT06761677
Start: 2025-06-09End: 2029-05-08Target: 43Updated: 2026-02-05
Phase 2
Study of CMX001 to Prevent/Control Cytomegalovirus Infection in R+ Hematopoietic Stem Cell Transplant Recipients
CompletedNCT00942305
Start: 2009-10-31End: 2012-01-31Updated: 2021-07-16
Phase 2 Study to Evaluate Brincidofovir for the Prevention of Adenovirus Disease
CompletedNCT01241344
Start: 2010-11-30End: 2013-06-30Updated: 2021-07-21
The AdAPT Trial; Adenovirus After Allogeneic Pediatric Transplantation
TerminatedNCT03339401
Start: 2017-12-22End: 2019-05-10Updated: 2021-01-25
Open Label Study of IV Brincidofovir in Adult Transplant Recipients With Adenovirus Viremia
WithdrawnNCT03532035
Start: 2018-12-15End: 2019-05-10Updated: 2021-07-21
An Open-Label Study , Safety and Tolerability of Brincidofovir for Post Exposure Prophylaxis of Ebola
WithdrawnNCT04268966
Start: 2014-10-31End: 2015-12-31Updated: 2020-02-26
Study to Confirm of the Safety and Tolerability of Brincidofovir in Subjects With BK Virus Infection (Viremia) After Kidney Transplantation
TerminatedNCT05511779
Start: 2022-10-14End: 2023-04-13Updated: 2024-12-04
Intravenous Brincidofovir as an Antiviral for Treatment of Progressive Multifocal Leukoencephalopathy: A Pilot Study
RecruitingNCT07511049
Start: 2026-06-05End: 2029-12-31Target: 24Updated: 2026-07-22
Phase 3
Study to Assess Brincidofovir Treatment of Serious Diseases or Conditions Caused by Double-stranded DNA Viruses
CompletedNCT01143181
Start: 2010-12-31End: 2012-12-31Updated: 2021-08-12
A Study of the Safety and Efficacy of CMX001 for the Prevention of CMV Infection in CMV-seropositive HCT Recipients
CompletedNCT01769170
Start: 2013-08-31End: 2016-01-31Updated: 2021-07-21
Study to Assess the Safety and Efficacy of Brincidofovir in Treatment of Early Versus Late Adenovirus Infection
CompletedNCT02087306
Start: 2014-03-31End: 2016-08-31Updated: 2021-08-13
A Phase 3 Study of Brincidofovir Versus Valganciclovir for the Prevention of Cytomegalovirus
TerminatedNCT02439957
Start: 2015-09-30End: 2016-07-31Updated: 2021-07-16
A Phase 3 Study of Brincidofovir Versus Valganciclovir for the Prevention of Cytomegalovirus Disease
TerminatedNCT02439970
Start: 2015-09-30End: 2016-01-30Updated: 2021-07-16
A phase III, multi-country, randomized, placebo-controlled, double-blinded adaptive platform trial to assess the efficacy and safety of treatments for participants with monkeypox virus disease
RecruitingPACTR202405860723287
Start: 2024-09-02Target: 422Updated: 2026-09-14
A Phase 3, Multicenter, Prospective, Randomized, Open-label Efficacy and Safety Study of Intravenous Brincidofovir versus Intravenous Cidofovir for Treatment of Adenovirus Infection in Pediatric and Adult Subjects After Allogeneic Hematopoietic Cell Transplantation (allo HCT)
Not yet recruitingCTIS2025-521903-28-00
Target: 72Updated: 2025-11-13
A Phase 3 Trial to Compare IV BCV Versus IV CDV for Treatment of Adenovirus Infection After Allo-HCT
RecruitingNCT07387367
Start: 2026-03-17End: 2028-06-30Target: 180Updated: 2026-08-10
Unknown Phase
A Multicenter Study to Obtain Retrospective Data for Subjects Previously Diagnosed With Adenovirus Infection to Serve as Matched Historical Controls for Study CMX001-304
TerminatedNCT02420080
Start: 2015-02-28End: 2016-09-30Updated: 2017-01-09
Expanded Access Protocol to Provide Brincidofovir for the Treatment of Serious Adenovirus Infection or Disease
NCT02596997
Updated: 2022-03-14