Brensocatib
Sponsors
Insmed Inc., University of Dundee, Insmed Incorporated
Conditions
Chronic Rhinosinusitis Without Nasal PolypsChronic Rhinosinusitis without Nasal Polyps (CRSsNP)Covid19Cystic FibrosisHealthy VolunteerHealthy VolunteersHepatic ImpairmentHidradenitis Suppurativa
Phase 1
A Study to Investigate the Effects of Brensocatib on QT Interval in Healthy Participants
CompletedNCT05355935
Start: 2022-04-27End: 2022-10-07Updated: 2023-03-27
A Study to Evaluate the Pharmacokinetics (PK) and Safety of a Single Dose of Brensocatib in Participants With Normal Hepatic Function and Participants With Hepatic Impairment
CompletedNCT05517525
Start: 2022-10-04End: 2023-06-01Updated: 2023-07-19
A Study of Brensocatib Following a Single Oral Administration in Participants With or Without Renal Impairment
CompletedNCT05673603
Start: 2021-07-20End: 2023-02-14Updated: 2023-04-18
A Study to Assess Pharmacokinetics (PK) of Brensocatib Alone and With Multiple Doses of Rifampin or Esomeprozole in Healthy Participants
CompletedNCT05826574
Start: 2023-05-10End: 2023-07-16Updated: 2023-08-21
A Study to Investigate Effect of Clarithromycin, a Strong CYP3A4 Inhibitor, on Brensocatib Pharmacokinetics in Healthy Participants
CompletedNCT05965570
Start: 2023-07-28End: 2023-09-22Updated: 2023-12-11
A Study of the Palatability and Acceptability of Different Brensocatib Oral Liquid Formulations in Healthy Participants
CompletedNCT06178783
Start: 2023-12-27End: 2024-01-04Updated: 2024-01-22
Phase 2
A Study to Assess the Safety, Tolerability, and Pharmacokinetics of Brensocatib Tablets in Adults With Cystic Fibrosis
CompletedNCT05090904
Start: 2021-11-30End: 2022-11-01Updated: 2026-03-12
A Study of the Efficacy and Safety of Brensocatib in Participants With Chronic Rhinosinusitis Without Nasal Polyps (CRSsNP)
CompletedNCT06013241
Start: 2023-10-30End: 2025-10-30Updated: 2025-11-10
A Phase 2b, Randomized, Double-Blind, Placebo-Controlled, Multicenter Study of the Efficacy and Safety of Brensocatib in Participants with Chronic Rhinosinusitis Without Nasal Polyps – The BiRCh Study
CompletedCTIS2022-502481-24-00
Start: 2024-05-23End: 2025-10-29Target: 203Updated: 2025-05-14
A Study of the Efficacy and Safety of Brensocatib in Adults With Moderate to Severe Hidradenitis Suppurativa (HS)
Active, not recruitingNCT06685835
Start: 2024-12-16End: 2026-11-17Updated: 2026-03-06
A Phase 2b, Randomized, Double-Blind, Placebo-Controlled, Multicenter Study of the Efficacy and Safety of Brensocatib in Adults with Moderate to Severe Hidradenitis Suppurativa – The CEDAR Study
RecruitingCTIS2024-515959-38-00
Start: 2025-03-06Target: 116Updated: 2025-09-22