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Brensocatib

DRUG14 trials

Sponsors

Insmed Inc., University of Dundee, Insmed Incorporated

Conditions

Chronic Rhinosinusitis Without Nasal PolypsChronic Rhinosinusitis without Nasal Polyps (CRSsNP)Covid19Cystic FibrosisHealthy VolunteerHealthy VolunteersHepatic ImpairmentHidradenitis Suppurativa

Phase 1

A Study to Investigate the Effects of Brensocatib on QT Interval in Healthy Participants
CompletedNCT05355935
Insmed IncorporatedHealthy Volunteer
Start: 2022-04-27End: 2022-10-07Updated: 2023-03-27
A Study to Evaluate the Pharmacokinetics (PK) and Safety of a Single Dose of Brensocatib in Participants With Normal Hepatic Function and Participants With Hepatic Impairment
CompletedNCT05517525
Insmed IncorporatedHepatic Impairment
Start: 2022-10-04End: 2023-06-01Updated: 2023-07-19
A Study of Brensocatib Following a Single Oral Administration in Participants With or Without Renal Impairment
CompletedNCT05673603
Insmed IncorporatedRenal Impairment
Start: 2021-07-20End: 2023-02-14Updated: 2023-04-18
A Study to Assess Pharmacokinetics (PK) of Brensocatib Alone and With Multiple Doses of Rifampin or Esomeprozole in Healthy Participants
CompletedNCT05826574
Insmed IncorporatedHealthy Volunteers
Start: 2023-05-10End: 2023-07-16Updated: 2023-08-21
A Study to Investigate Effect of Clarithromycin, a Strong CYP3A4 Inhibitor, on Brensocatib Pharmacokinetics in Healthy Participants
CompletedNCT05965570
Insmed IncorporatedHealthy Volunteers
Start: 2023-07-28End: 2023-09-22Updated: 2023-12-11
A Study of the Palatability and Acceptability of Different Brensocatib Oral Liquid Formulations in Healthy Participants
CompletedNCT06178783
Insmed IncorporatedHealthy Volunteers
Start: 2023-12-27End: 2024-01-04Updated: 2024-01-22
A Study to Assess the Potential CYP3A Induction Effect of Brensocatib on the Pharmacokinetics (PK) of Midazolam in Healthy Participants
Not yet recruitingNCT07859007
Insmed IncorporatedHealthy Volunteers
Start: 2026-10-29End: 2026-11-25Target: 26Updated: 2026-10-05

Phase 2

Phase 3

Unknown Phase

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