Bradykinin

DRUG9 trials

Conditions

Coronary Artery DiseaseDiabetes Type 2HealthyHeart TransplantationHyperlipidemiaHypertensionObesityPrehypertension

Phase 1

Tissue-Type Plasminogen Activator (t-PA) Release Predicts Major Adverse Cardiac Events (MACE) in Patients With Non-critical Coronary Artery Disease

TerminatedNCT00868855

Vanderbilt UniversityCoronary Artery Disease

Start: 2003-12-31End: 2010-12-31Updated: 2017-12-13

Phase 2

Endothelial Hyperpolarization in Humans

TerminatedNCT00166166

Emory UniversityHyperlipidemia

Start: 2002-07-31End: 2013-01-31Updated: 2018-08-15

Phase 4

Nebivolol and Endothelial Regulation of Fibrinolysis (NERF)

CompletedNCT01595516

University of Colorado, BoulderHypertension, Prehypertension

Start: 2012-02-29End: 2017-10-31Updated: 2019-06-25

Mechanism(s) Underlying Hypotensive Response to ARB/NEP Inhibition - Aim 1

TerminatedNCT03738878

Vanderbilt University Medical CenterHypertension

Start: 2018-11-15End: 2024-12-01Updated: 2025-08-03

Unknown Phase

Brachial Artery t-PA Release in Heart Transplant Recipients

WithdrawnNCT00780637

Vanderbilt UniversityHeart Transplantation

Start: 2008-10-31End: 2011-05-31Updated: 2016-07-15

Characterization of Brachial Arterial t-PA Release, Endothelial Function, Obesity and Inflammation

TerminatedNCT00780481

Vanderbilt UniversityObesity

Start: 2007-01-31End: 2011-05-31Updated: 2017-07-14

Intracoronary Bradykinin Mediated t-PA Release in Heart Transplant Recipients

WithdrawnNCT00780377

Vanderbilt UniversityHeart Transplantation

Start: 2008-10-31End: 2011-05-31Updated: 2017-03-20

Pharmacogenetics of Ace Inhibitor-Associated Angioedema

CompletedNCT01413542

Vanderbilt UniversityDiabetes Type 2, Hypertension

Start: 2011-11-30End: 2014-07-31Updated: 2015-11-04

Comparative Effects of Aspirin and NHP-544C

CompletedNCT02189122

Vanderbilt UniversityHealthy

Start: 2014-07-31End: 2015-07-31Updated: 2016-07-12

Journal of the American Heart Association2017-11-019 citations

Contribution of endothelium-derived hyperpolarizing factor to exercise-induced vasodilation in health and hypercholesterolemia

Vascular Medicine2015-02-0123 citations

Dipeptidyl‐Peptidase 4 Inhibition and the Vascular Effects of Glucagon‐like Peptide‐1 and Brain Natriuretic Peptide in the Human Forearm

Journal of the American Heart Association2014-08-1538 citations

Differences in Vascular Nitric Oxide and Endothelium-Derived Hyperpolarizing Factor Bioavailability in Blacks and Whites

Arteriosclerosis Thrombosis and Vascular Biology2014-03-2859 citations

Substance P Increases Sympathetic Activity During Combined Angiotensin-Converting Enzyme and Dipeptidyl Peptidase-4 Inhibition

Hypertension2014-02-1165 citations

Endothelium-derived hyperpolarizing factor determines resting and stimulated forearm vasodilator tone in health and in disease.

2011-05-0965 citations