BPZE1

BIOLOGICAL4 trials

Sponsors

Institut National de la Santé Et de la Recherche Médicale, France, National Institute of Allergy and Infectious Diseases (NIAID), ILiAD Biotechnologies

Conditions

Bordetella Pertussis, Whooping CoughPertussisPertussis ImmunisationPertussis/Whooping CoughWhooping Cough

Phase 1

First Adult Safety Trial on Nasal Live Attenuated B. Pertussis Vaccine

CompletedNCT01188512

Institut National de la Santé Et de la Recherche Médicale, FrancePertussis

Start: 2010-08-31End: 2012-01-31Updated: 2025-12-10

Study of BPZE1 (High Dose) Nasal Live Attenuated B. Pertussis Vaccine

CompletedNCT02453048

Institut National de la Santé Et de la Recherche Médicale, FrancePertussis, Whooping Cough

Start: 2015-09-01End: 2017-12-01Updated: 2026-02-27

Phase 2

Safety and Immunogenicity of Intranasal BPZE1 Vaccination in Healthy Adults

CompletedNCT03541499

National Institute of Allergy and Infectious Diseases (NIAID)Pertussis, Pertussis Immunisation

Start: 2018-10-23End: 2020-05-15Updated: 2024-09-19

Pertussis Challenge Study in Adults Vaccinated With BPZE1

CompletedNCT05461131

ILiAD BiotechnologiesBordetella Pertussis, Whooping Cough, Pertussis/Whooping Cough

Start: 2022-06-20End: 2023-10-26Updated: 2025-03-12

Related Papers

Efficacy, immunogenicity, and safety of the live attenuated nasal pertussis vaccine, BPZE1, in the UK: a randomised, placebo-controlled, phase 2b trial using a controlled human infection model with virulent Bordetella pertussis.

2025-12-011 citations

Safety and immunogenicity of the live attenuated intranasal pertussis vaccine BPZE1: a phase 1b, double-blind, randomised, placebo-controlled dose-escalation study.

2020-07-1746 citations

Live attenuated pertussis vaccine BPZE1 induces a broad antibody response in humans

Journal of Clinical Investigation2020-01-1660 citations

B-cell responses after intranasal vaccination with the novel attenuated Bordetella pertussis vaccine strain BPZE1 in a randomized phase I clinical trial

Vaccine2014-04-2929 citations

A Phase I Clinical Study of a Live Attenuated Bordetella pertussis Vaccine - BPZE1; A Single Centre, Double-Blind, Placebo-Controlled, Dose-Escalating Study of BPZE1 Given Intranasally to Healthy Adult Male Volunteers

PLoS ONE2014-01-08140 citations