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Boserolimab

BIOLOGICAL8 trials

Sponsors

Merck Sharp & Dohme LLC

Conditions

Carcinoma, Non-Small-Cell LungEarly Triple Negative Breast CancerFirst-line treatment of participants with extensive-stage small cell lung cancerNon-small Cell Lung CancerPharmacokineticsSmall Cell Lung CancerSolid TumorTriple Negative Breast Neoplasms

Phase 1

Phase 2

KEYMAKER-U01 Substudy 3: Efficacy and Safety Study of Pembrolizumab (MK-3475) When Used With Investigational Agents in Participants With Advanced Non-small Cell Lung Cancer (NSCLC), Previously Treated With Anti-programmed Cell Death Receptor Ligand 1 (PD-L1) Therapy (MK-3475-01C/KEYMAKER-U01C)
CompletedNCT04165096
Merck Sharp & Dohme LLCCarcinoma, Non-Small-Cell Lung
Start: 2020-01-21End: 2025-05-28Updated: 2025-06-25
Efficacy and Safety of Pembrolizumab Plus Investigational Agents in Combination With Chemotherapy as First-Line Treatment in Extensive-Stage Small Cell Lung Cancer (ES-SCLC) (MK-3475-B99/ KEYNOTE-B99)
CompletedNCT04924101
Merck Sharp & Dohme LLCSmall Cell Lung Cancer
Start: 2021-07-15End: 2025-06-23Updated: 2025-07-23
KEYMAKER-U01 Substudy 1: A Phase 2, Umbrella Study with Rolling Arms of Investigational Agents with Pembrolizumab in Combination with Chemotherapy in Treatment-Naive Patients with Advanced Non-small Cell Lung Cancer (NSCLC)
CompletedCTIS2023-506932-33-00
Merck Sharp & Dohme LLCnon-small cell lung cancer
Start: 2020-10-20End: 2025-09-18Target: 163Updated: 2025-11-14
KEYMAKER-U01 Master Study: A Phase 2, Umbrella Study with Rolling Arms of Investigational Agents with either Pembrolizumab in Combination with Chemotherapy or with Pembrolizumab Alone in Patients with Advanced Non-small Cell Lung Cancer (NSCLC) KEYMAKER-U01 Substudy 3: A Phase 2, Umbrella Study with Rolling Arms of Investigational Agents in Combination with Pembrolizumab in Patients with Advanced Non-small Cell Lung Cancer (NSCLC) Previously Treated with anti-PD-(L)1 Therapy
CompletedCTIS2023-506934-56-00
Merck Sharp & Dohme LLCNon-small Cell Lung Cancer
Start: 2020-10-20End: 2025-05-12Target: 45Updated: 2025-06-04
A Phase 2 Study to Evaluate the Efficacy and Safety of Pembrolizumab plus Investigational Agents in Combination with Etoposide and Cisplatin or Carboplatin for the First-Line Treatment of Participants with Extensive-Stage Small Cell Lung Cancer (KEYNOTE-B99)
CompletedCTIS2023-506538-56-00
Merck Sharp & Dohme LLCFirst-line treatment of participants with extensive-stage small cell lung cancer
Start: 2021-08-12End: 2025-06-20Target: 76Updated: 2025-06-17
A Clinical Study of Boserolimab (MK-5890) With Pembrolizumab and Chemotherapy in People With Early Triple-Negative Breast Cancer (MK-5890-003)
WithdrawnNCT06829199
Merck Sharp & Dohme LLCEarly Triple Negative Breast Cancer
Start: 2025-03-26End: 2031-03-18Updated: 2026-02-19

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